Results 51 to 60 of about 4,132 (213)

The temporal and spatial endophytic fungal community of Huperzia serrata: diversity and relevance to huperzine A production by the host

BMC Microbiology, 2022
Background Plants maintain the steady-state balance of the mutually beneficial symbiosis relationship with their endophytic fungi through secondary metabolites.
Zhuhui Shen, Xubing Liu, Jia Yang, Yanli Wang, Kai Yao, Qingmiao Huo, Yanping Fu, Yahui Wei, Bin Guo   +8 more
doaj   +1 more source

Endophytic Fungal Community of Huperzia serrata: Diversity and Relevance to the Production of Huperzine A by the Plant Host

Molecules, 2021
As the population ages globally, there seem to be more people with Alzheimer’s disease. Unfortunately, there is currently no specific treatment for the disease. At present, Huperzine A (HupA) is one of the best drugs used for the treatment of Alzheimer’s
Lingli Cui, Hamza Armghan Noushahi, Yipeng Zhang, Jinxin Liu, Andreea Cosoveanu, Ying Liu, Ling Yan, Jing Zhang, Shaohua Shu   +8 more
doaj   +1 more source

Prediction of anti-Alzheimer’s activity of flavonoids targeting acetylcholinesterase in silico [PDF]

, 2017
Introduction – Prenylated and pyrano-flavonoids of the genus Artocarpus J. R. Forster & G. Forster are well known for their acetylcholinesterase (AchE) inhibitory, anticholinergic, antiinflammatory, antimicrobial, antioxidant, antiproliferative and ...
Abdullah, SA, Basar, N, Choudhury, MD, Choudhury, PR, Das, S, Jamil, S, Laskar, MA, Lathiff, SMA, Mitra, A, Nahar, L, Sarker, SD, Talukdar, AD   +11 more
core   +1 more source

Huperzine A

Drugs in R & D, 2004
Huperzine A, an alkaloid isolated from Huperzia serrata, is a putative nootropic agent developed by the Chinese Academy of Sciences. Huperzine A is currently in phase III trials in China for the treatment of patients with Alzheimer's disease. The mechanism of action of huperzine A is suggested to be facilitated through the slow reversible inhibition of
openaire   +2 more sources

A network model to investigate structural and electrical properties of proteins

, 2007
One of the main trend in to date research and development is the miniaturization of electronic devices. In this perspective, integrated nanodevices based on proteins or biomolecules are attracting a major interest.
Alfinito E, Atilgan A R, Cecilia Pennetta, Debye P, Edérlyi A, Eleonora Alfinito, Fisher Weiss T, Kim M K, Lino Reggiani, McCammon A, Menon S T, Pennetta C, Pennetta C, Schlag E W, Taketomi H, Warshel A   +15 more
core   +1 more source

Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases [PDF]

, 2015
The prion protein (PrP) binds to various molecular partners, but little is known about their potential impact on the pathogenesis of prion diseases.
Acquatella-Tran Van Ba, I., Béringue, V., Chatonnet, A., Goffic, R. Le, Grznarova, K., Herzog, Laetitia, Muñoz-Torrero López-Ibarra, Diego, Nachon, Florian, Rezaei, H., Torrent, Joan, Trovaslet, M., Vílchez Acosta, Alba del Valle   +11 more
core   +4 more sources

Behavioral Recovery and Early Decision Making in Patients with Prolonged Disturbance in Consciousness after Traumatic Brain Injury [PDF]

, 2020
The extent of behavioral recovery that occurs in patients with traumatic disorders of consciousness (DoC) following discharge from the acute care setting has been under-studied and increases the risk of overly pessimistic outcome prediction.
Bagiella, Emilia, Christoforou, Andrea, Giacino, Joseph T., Hammond, Flora M., Long, David, Maurer-Karattup, Petra, Sherer, Mark   +6 more
core   +1 more source

Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

Molecules, 2014
A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa.
Nguyen Ngoc Chuong, Nguyen Thi Thu Huong, Tran Manh Hung, Tran Cong Luan   +3 more
doaj   +1 more source

Huperzine A and Huperzine B Production by Prothallus Cultures of Huperzia selago (L.) Bernh. ex Schrank et Mart

Molecules, 2020
This is the first report of an efficient and effective procedure to optimize the biosynthesis of huperzine A (HupA) and huperzine B (HupB) in vitro from Huperzia selago gametophytes. Axenic tissue cultures were established using spores collected from the
Wojciech J. Szypuła, Beata Wileńska, Aleksandra Misicka, Agnieszka Pietrosiuk   +3 more
doaj   +1 more source

Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease

Molecules, 2021
Huperzine A (HupA), an alkaloid found in the club moss Huperzia serrata, has been used for centuries in Chinese folk medicine to treat dementia.
María Jesús Friedli, Nibaldo C. Inestrosa   +1 more
doaj   +1 more source