Results 201 to 210 of about 65,627 (261)

Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathology. [PDF]

Cell Rep
Mohan N, Ramakrishnan S, Sun X, Sun Y, Connors T, Chai V, Piermarini E, Baas PW, Cai J, Liu M, Qiang L.   +10 more
europepmc   +1 more source

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

Cell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo, Qiang Qin, Wenting She, Xiangying Wang, Xiqin Li, Chenxuan Shu, Ruohan Li, Ziwei Li, Dongjie Fu, Yan He, Qingsong Ye   +10 more
wiley   +1 more source

Inhibition of FKBP51 alleviates depressive-like behaviors via AKT/mTOR-dependent autophagy and synaptic plasticity. [PDF]

Int J Neuropsychopharmacol
Li C, Huang J, Ge H, Si L, Wu L, Xie Y, Xiao L, Wang G.   +7 more
europepmc   +1 more source

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Sex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking. [PDF]

Neuropsychopharmacology
Freeman C, Radoman M, Martins JS, Lacadie C, Seo D, Sinha R.   +5 more
europepmc   +1 more source

Hyperactivation of mTORC1 blocks stem cell fate transitions through TFE3-NuRD association. [PDF]

EMBO Rep
Li P, Xu S, Wu X, Gao Y, Ahmed T, Huang Y, Qin D, Qin B, Wang L, Xu X.   +9 more
europepmc   +1 more source

Loss of Proteostasis and Early-Onset Neurodegeneration in Down Syndrome: From Mechanisms to Interventions. [PDF]

Antioxidants (Basel)
Tramutola A, Lanzillotta C, Di Domenico F, Barone E, Perluigi M.   +4 more
europepmc   +1 more source

MX1⁺ effector T cells hyperactivation at the maternal-fetal interface in unexplained recurrent pregnancy loss. [PDF]

J Transl Med
Ou M, Yu L, Gao Y, Huang L, Deng W, Zhang J, Zou H, Chen D, Du L, Zhang S.   +9 more
europepmc   +1 more source

NOD2 hyperactivates NLRP1 in disease.

openaire   +1 more source