Results 41 to 50 of about 3,484 (175)

Emergence of KPC-2 and NDM-13-coproducing carbapenem-resistant hypervirulent Klebsiella pneumoniae with high-risk sequence type ST11

Frontiers in Microbiology
BackgroundCarbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) co-producing KPC and NDM poses serious threats to public health. This study aimed to elucidate the molecular mechanisms underlying the resistance and virulence of a clinical CR ...
Jia Tao, Jia Tao, Liru Wang, Liru Wang, Na Yang, Hui Fu, Hui Fu, Xinxin Hu, Xinxin Hu, Tingyu Lai, Jianning Jin, Gang Li, Gang Li   +12 more
doaj   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Clinical and Microbiological Characteristics of Klebsiella pneumoniae Bloodstream Infection in a Chinese Hospital: Hypervirulent and Multiclonal

Infection and Drug Resistance, 2022
Zike Sheng,1,* Junjie Li,2,* Tingting Chen,3 Yan Zhu,4 Xueping Yu,5 Xiuhua He,5 Yijuan Zheng,5 Cuiping Ma,6 Minghui Zheng,5 Peiyun Wang,1 Ziqiang Li,1 Yumin Xu,7 Qing Xie,1 Zhijun Su,5 Sumei Chen5 1Department of Infectious Diseases, Ruijin ...
Sheng Z, Li J, Chen T, Zhu Y, Yu X, He X, Zheng Y, Ma C, Zheng M, Wang P, Li Z, Xu Y, Xie Q, Su Z, Chen S   +14 more
doaj  

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Characterization of hypervirulent Klebsiella pneumoniae isolates in Belgium

European Journal of Clinical Microbiology & Infectious Diseases, 2022
Hypervirulent Klebsiella pneumoniae (hvKp) raised concern worldwide. We studied 22 hvKp clinical invasive isolates referred to the Belgian national reference laboratory between 2014 and 2020. Sixty-four percent of the isolates expressed K2 capsular serotype and belonged to 7 different MLST lineages, while 32% expressed K1 (all belonging to ST23) and ...
Anantharajah, Ahalieyah, Deltombe, Matthieu, de Barsy, Marie, Evrard, Stephanie, Denis, Olivier, Bogaerts, Pierre, Hallin, Marie, Miendje Deyi, Véronique Yvette, Piérard, Denis, Bruynseels, Peggy, Boelens, Jerina, Glupczynski, Youri, Huang, Te-Din   +12 more
openaire   +4 more sources

Epidemiological characteristics an outbreak of ST11 multidrug-resistant and hypervirulent Klebsiella pneumoniae in Anhui, China

Frontiers in Microbiology, 2022
Klebsiella pneumoniae has become a primary threat to global health because of its virulence and resistance. In 2015, China reported multidrug-resistant (MDR) and hypervirulent K. pneumoniae (hvKp) isolates.
Zhien He, Weifeng Xu, Hang Zhao, Wei Li, Yuanyuan Dai, Huaiwei Lu, Liping Zhao, Changfeng Zhang, Yujie Li, Baolin Sun   +9 more
doaj   +1 more source

Fusarium sacchari 14‐3‐3 Protein FsBmh1 Sequesters a Novel Elicitor FsEcm33 to Evade Host Immunity

Molecular Plant Pathology, Volume 27, Issue 7, July 2026.
When the elicitor FsEcm33 is sprayed onto Nicotiana benthamiana leaves, it enters the apoplast, triggering PAMP‐triggered immunity (PTI) that depends on NbRE02, NbBAK1, and NbSOBIR1. However, upon Fusarium sacchari infection, FsBmh1 binds FsEcm33 to prevent its localization on the cell surface, escaping PTI to allow colonization.
Yuejia Chen, Yuming Lin, Lixian Zhao, Gengzhong Cheng, Liuting Huang, Yueying Zhao, Zhien Wei, Yuanzhi Mao, Xiaoxi Feng, Xipu He, Baoshan Chen, Jisen Zhang, Ziting Yao, Chengwu Zou   +13 more
wiley   +1 more source

Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae

Infection and Drug Resistance, 2022
Shiwei Liang,1,2,* Huijun Cao,1,* Fei Ying,1 Chenchen Zhang2 1Centre for Clinical Laboratories, the Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China; 2School of Clinical Laboratory Science, Guizhou Medical ...
Liang S, Cao H, Ying F, Zhang C
doaj  

Interplay Between Virulence Genes, Antimicrobial Resistance Profiles, and Biofilm Formation in Klebsiella pneumoniae Causing Urinary Tract Infections in North Lebanon

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
– Figure design (single panel) Central icon: K. pneumoniae cell Left panel – Virulence genes (icons): Adhesion: fimH, mrkD → strong biofilm Capsule/regulation: magA, rmpA Siderophores: entB, iucA → iron uptake Right panel – Outcomes: Biofilm strength (weak → strong gradient) Antibiotic resistance (ESBL, MDR) Bottom split: Hospital‐acquired → strong ...
Mazen Zaylaa, Rayan Farha, Jana Taleb, Amal Saad, Omar El Gharbawy, Ricardo Sarraf, Ibtihal Kassam, Chadi Hamdach, Nisrine Bissar   +8 more
wiley   +1 more source

Pathogenic Mechanisms of V. vulnificus and Its Role in the Development of Sepsis

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Sorafenib attenuates urethral scar formation by inhibiting β‐catenin signaling in fibroblasts, which downregulates the SLC7A11/GPX4 antioxidant axis and triggers ferroptosis. This β‐catenin–ferroptosis coupling effectively suppresses fibrogenesis, highlighting sorafenib as a promising drug‐repurposing candidate for urethral stricture.
Zhongying Yu, Xianzhong Zhu, Shijie Tang, Shubo Yang, Jinyu Li, Lianzhong Luo, Yan Tan, Jun Yin   +7 more
wiley   +1 more source