Results 21 to 30 of about 4,451 (204)

Phenotypic and Genotypic Characterization of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae ST17-KL38 Clinical Isolate Harboring the Carbapenemase IMP-4

Microbiology Spectrum, 2022
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a threat to global public health. We characterized a sequence type 17 (ST17) K. pneumoniae clinical isolate that was resistant to carbapenems and belonged to serotype KL38/O2.
Jintao He, Xiaoxing Du, Xi Zeng, Robert A. Moran, Willem van Schaik, Quanming Zou, Yunsong Yu, Jinyong Zhang, Xiaoting Hua   +8 more
doaj   +1 more source

Pathogenesis of Hypervirulent Group A Streptococcus [PDF]

Japan Journal of Medicine, 2018
Group A Streptococcus (GAS) causes common pharyngitis and skin infections and occasional severe invasive infections. This review describes the recent progress on the pathogenesis of hypervirulent GAS. CovRS mutations are frequent among invasive GAS isolates and lead to hypervirulence. GAS CovRS mutants can be selected in vivo by neutrophils.
Mengyao, Liu, Benfang, Lei
openaire   +2 more sources

Emergence of colistin-resistant hypervirulent Klebsiella pneumoniae (CoR-HvKp) in China

Emerging Microbes and Infections, 2022
Colistin is regarded as a last-resort agent to combat infections caused by multidrug-resistant (MDR) Gram-negative bacteria, especially carbapenem-resistant isolates.
Xiaoyu Liu, Yarong Wu, Ying Zhu, Peiyao Jia, Xue Li, Xinmiao Jia, Wei Yu, Yujun Cui, Ruifu Yang, Wei Xia, Yingchun Xu, Qiwen Yang   +11 more
doaj   +1 more source

Genomics of Klebsiella pneumoniae Species Complex Reveals the Circulation of High-Risk Multidrug-Resistant Pandemic Clones in Human, Animal, and Environmental Sources

Microorganisms, 2022
The Klebsiella species present a remarkable genetic and ecological diversity, being ubiquitous in nature. In particular, the Klebsiella pneumoniae species complex (KpSC) has emerged as a major public health threat in the world, being an interesting model
Sergio Morgado, Erica Fonseca, Ana Carolina Vicente   +2 more
doaj   +1 more source

Bloodstream Infections Caused by Klebsiella pneumoniae Carbapenemase–Producing P. aeruginosa Sequence Type 463, Associated With High Mortality Rates in China: A Retrospective Cohort Study

Frontiers in Cellular and Infection Microbiology, 2021
ObjectivesRecently, KPC-producing P. aeruginosa has rapidly emerged and expanded in East China. Here we described the clinical impact and characteristics of bloodstream infections (BSIs) from the dominant KPC-producing CRPA belonging to Sequence Type (ST)
Hangbin Hu, Yan Zhang, Piaopiao Zhang, Jie Wang, Qing Yuan, Weixiao Shi, Sheng Zhang, Haiting Feng, Yunbo Chen, Meihong Yu, Hongchao Chen, Yan Jiang, Qing Yang, Tingting Qu, Tingting Qu   +14 more
doaj   +1 more source

Acquisition of the Conjugative Virulence Plasmid From a CG23 Hypervirulent Klebsiella pneumoniae Strain Enhances Bacterial Virulence

Frontiers in Cellular and Infection Microbiology, 2021
The emergence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) has become a hot topic and confounding problem for clinicians and researchers alike.
Dongxing Tian, Weiwen Wang, Meng Li, Wenjie Chen, Ying Zhou, Yunkun Huang, Zike Sheng, Xiaofei Jiang   +7 more
doaj   +1 more source

Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A Streptococcus M1T1 clone [PDF]

, 2010
Background. The recent resurgence of invasive group A streptococcal disease has been paralleled by the emergence of the M1T1 clone. Recently, invasive disease initiation has been linked to mutations in the covR/S 2-component regulator.
Hollands, Andrew, Timmer, Anjuli M., Timmer, AM, Hollands, A, Anjuli M. Timmer, Pence, Morgan A., Mark J. Walker, Nizet, V, Turnbull, L, Turnbull, Lynne, Whitchurch, CB, Morgan A. Pence, Victor Nizet, Cynthia B. Whitchurch, Walker, MJ, Whitchurch, Cynthia B., Pence, MA, Osvath, SR, Andrew Hollands, Sarah R. Osvath, Walker, Mark J., Nizet, Victor, Osvath, Sarah R., Lynne Turnbull   +23 more
core   +3 more sources

Molecular Characterization of the Convergent Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Strain K1-ST23, Collected in Chile during the COVID-19 Pandemic

Microbiology Spectrum, 2023
The aim of this study was to investigate the genomic features of a carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) isolate (K-2157) collected in Chile.
Felipe Morales-León, Maximiliano Matus-Köhler, Pablo Araya-Vega, Felipe Aguilera, Ignacio Torres, Rodrigo Vera, Camila Ibarra, Sebastián Venegas, Helia Bello-Toledo, Gerardo González-Rocha, Andrés Opazo-Capurro   +10 more
doaj   +1 more source

The case for hypervirulence through gene deletion in Mycobacterium tuberculosis.

, 2008
Deletion of genes in a pathogen is commonly associated with a reduction in its ability to cause disease. However, some rare cases have been described in the literature whereby deletion of a gene results in an increase in virulence.
Frita, R, Ten Bokum, A M C, Bancroft, G J, Movahedzadeh, F, Stoker, N G, LSHTM, ten Bokum, Annemieke MC, Frita, Rosangela, Stoker, Neil G, Bancroft, Gregory J, Movahedzadeh, Farahnaz   +10 more
core   +3 more sources

Differential Virulence by Strains of Cucumber mosaic virus is Mediated by the 2b Gene

Molecular Plant-Microbe Interactions, 2002
The approximately 12-kDa 2b protein, encoded by all cucumoviruses, had been shown to play an important role in viral long-distance movement, hypervirulence, and suppression of post-transcriptional gene silencing.
Bu-Jun Shi, Peter Palukaitis, Robert H. Symons   +2 more
doaj   +1 more source