Results 11 to 20 of about 5,988 (207)

Antimicrobial Resistance, Virulence, and Genomic Characteristics of <i>Klebsiella pneumoniae</i> Isolated From Four Host Sources in Northeast China. [PDF]

Transbound Emerg Dis
Klebsiella pneumoniae is an important emerging pathogen leading to serious clinical outcomes as the multidrug‐resistant (MDR) isolates arise. While K. pneumoniae is a well‐known pathogen in human clinical settings, its risks in nonhuman hosts and potential for cross‐species transmission remain poorly understood. In this study, we performed whole‐genome
Xu Q, Fan C, Liu Y, Lu X, Song W, Du S, Zhu Y, Xie F, Zhang W.   +8 more
europepmc   +2 more sources

Hypervirulent Klebsiella pneumoniae

Infection and Drug Resistance, 2023
Junjun Chen,1,2 Huan Zhang,1,3 Xuelian Liao1,2 1Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Critical Care Medicine, West China Tianfu Hospital of Sichuan University ...
Chen J, Zhang H, Liao X
doaj   +3 more sources

Evolutionary Origins and Virulence Determinants of ST25 Hypervirulent <i>Klebsiella pneumoniae</i> in Swine: Genomic Insights and Functional Validation. [PDF]

Transbound Emerg Dis
The global spread of multidrug‐resistant hypervirulent Klebsiella pneumoniae (MDR‐HvKp), among which carbapenem‐resistant strains are of major concern, poses a severe threat to public health due to its high mortality rate and extremely limited treatment options.
Chen Z, Liu Y, Du C, Gao S, Zhai L, Schwarz S, Liu W, Li Q, Li L, Yu R, Zhao Y, Yao H, Luo L, Liu X, Xu C, Du XD.   +15 more
europepmc   +2 more sources

Mortality risk of carbapenem-resistant hypervirulent Klebsiella pneumoniae vs. classical CR-KP: a systematic review and meta-analysis [PDF]

Frontiers in Public Health
BackgroundCarbapenem-resistant Klebsiella pneumoniae (K. pneumoniae, CR-KP) and hypervirulent K. pneumoniae (hvKP) represent two major clinical threats, due to high antimicrobial resistance and enhanced pathogenicity, respectively.
Jialiang Chen, Yue Hou, Jingang Shi, Xiaoyi Gao, Guowei Liang   +4 more
doaj   +2 more sources

Virulence Factors in Hypervirulent Klebsiella pneumoniae [PDF]

Frontiers in Microbiology, 2021
Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae (cKP), with hypermucoviscosity and hypervirulence, causing community-acquired infections, including pyogenic liver abscess, pneumonia, meningitis, and endophthalmitis.
Jie Zhu, Tao Wang, Liang Chen, Liang Chen, Hong Du   +4 more
openaire   +3 more sources

Hypervirulent Klebsiella pneumoniae [PDF]

Clinical Microbiology Reviews, 2019
Hypervirulent K. pneumoniae (hvKp) is an evolving pathotype that is more virulent than classical K. pneumoniae (cKp). hvKp usually infects individuals from the community, who are often healthy.
Thomas A, Russo, Candace M, Marr
openaire   +2 more sources

Hypervirulent Klebsiella pneumoniae [PDF]

Open Forum Infectious Diseases, 2014
Abstract Hypervirulent strains of Klebsiella pneumoniae are associated with abscess formation, commonly hepatic, and metastatic spread, even in healthy patients. We describe a case of this clinical syndrome, genotypic and phenotypic features of the isolate, and briefly review epidemiology, clinical manifestations, and pathogenesis of ...
Patel, Payal K., Karchmer, Adolf, Russo, Thomas A.   +2 more
openaire   +3 more sources

Phenotypic and Genotypic Characterization of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae ST17-KL38 Clinical Isolate Harboring the Carbapenemase IMP-4

Microbiology Spectrum, 2022
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a threat to global public health. We characterized a sequence type 17 (ST17) K. pneumoniae clinical isolate that was resistant to carbapenems and belonged to serotype KL38/O2.
Jintao He, Xiaoxing Du, Xi Zeng, Robert A. Moran, Willem van Schaik, Quanming Zou, Yunsong Yu, Jinyong Zhang, Xiaoting Hua   +8 more
doaj   +1 more source

Emergence of colistin-resistant hypervirulent Klebsiella pneumoniae (CoR-HvKp) in China

Emerging Microbes and Infections, 2022
Colistin is regarded as a last-resort agent to combat infections caused by multidrug-resistant (MDR) Gram-negative bacteria, especially carbapenem-resistant isolates.
Xiaoyu Liu, Yarong Wu, Ying Zhu, Peiyao Jia, Xue Li, Xinmiao Jia, Wei Yu, Yujun Cui, Ruifu Yang, Wei Xia, Yingchun Xu, Qiwen Yang   +11 more
doaj   +1 more source

Genomics of Klebsiella pneumoniae Species Complex Reveals the Circulation of High-Risk Multidrug-Resistant Pandemic Clones in Human, Animal, and Environmental Sources

Microorganisms, 2022
The Klebsiella species present a remarkable genetic and ecological diversity, being ubiquitous in nature. In particular, the Klebsiella pneumoniae species complex (KpSC) has emerged as a major public health threat in the world, being an interesting model
Sergio Morgado, Erica Fonseca, Ana Carolina Vicente   +2 more
doaj   +1 more source