Results 11 to 20 of about 678,452 (368)
Purification and Characterization of Hypoxia-inducible Factor 1 [PDF]
Journal of Biological Chemistry, 1995 Hypoxia-inducible factor 1 (HIF-1) is a DNA-binding protein that activates erythropoietin (Epo) gene transcription in Hep3B cells subjected to hypoxia or cobalt chloride treatment. HIF-1 DNA binding activity is also induced by hypoxia or cobalt in non-Epo-producing cells, suggesting a general role for HIF-1 in hypoxia signal transduction and ...
G L, Wang, G L, Semenza
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Hypoxia-Inducible Factor 1 and Cardiovascular Disease [PDF]
Annual Review of Physiology, 2014 Cardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species.
G. Semenza
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Antioxidants, 2017 The importance of the tumor microenvironment for cancer progression and therapeutic resistance is an emerging focus of cancer biology. Hypoxia, or low oxygen, is a hallmark of solid tumors that promotes metastasis and represents a significant obstacle to
Rachel K. Toth, Noel A. Warfel
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Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1 [PDF]
Journal of Biological Chemistry, 1996 Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor that regulates hypoxia-inducible genes including the human erythropoietin (EPO) gene.
Bing‐Hua Jiang +4 more
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Hypoxia-inducible factor 1 and breast cancer metastasis [PDF]
Journal of Zhejiang University-SCIENCE B, 2015 Accumulating evidence has shown that the hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating breast cancer progression and metastasis. The effects of hypoxia-inducible factor 1 (HIF-1), a master regulator of the hypoxic response, have been extensively studied during these processes.
Zhao-Ji, Liu +2 more
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Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. [PDF]
PLoS ONE, 2017 Inflammation and hypoxia are hallmarks of inflammatory bowel disease. Low oxygen levels activate hypoxia-inducible factors as central transcriptional regulators of cellular responses to hypoxia, particularly in myeloid cells where hypoxia-inducible ...
Veronika Bäcker +4 more
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The Role of Hypoxia-Inducible Factor-1 Alpha in Renal Disease
Molecules, 2022 Partial pressure of oxygen (pO2) in the kidney is maintained at a relatively stable level by a unique and complex functional interplay between renal blood flow, glomerular filtration rate (GFR), oxygen consumption, and arteriovenous oxygen shunting.
Huixia Liu, Yujuan Li, J. Xiong
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Biomedicines, 2020 Oxygen (O2) is essential for human life. Molecular oxygen is vital for the production of adenosine triphosphate (ATP) in human cells. O2 deficiency leads to a reduction in the energy levels that are required to maintain biological functions.
Kiichi Hirota
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Research progress of HIF-1 mediated autophagy in cardiac diseases [PDF]
Jichu yixue yu linchuang, 2021 Hypoxia-inducible factor 1 (HIF-1) regulates the expression of target genes to keep the balance between oxygen supply and oxygen consumption, maintains oxygen homeostasis.
ZHANG Liu-jie, LI Jing, WU Bo
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Deterioration of alveolar development in mice with both HIF-3α knockout and HIF-2α knockdown
BMC Research Notes, 2018 Objective Earlier studies from our group using hypoxia-inducible factor 3α knockout mice showed impairments in lung remodeling and lung endothelial cells.
Firman Zulkifli Amin +2 more
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