Results 11 to 20 of about 649,237 (386)
Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. [PDF]
, 2000 Transcription of hypoxia-inducible genes is regulated by hypoxia response elements (HREs) located in either the promoter or enhancer regions. Analysis of these elements reveals the presence of one or more binding sites for hypoxia-inducible factor 1 (HIF-
Alessandro Weisz +8 more
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Hypoxia-Inducible Factor 1 and Cardiovascular Disease [PDF]
Annual Review of Physiology, 2014 Cardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species.
G. Semenza
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Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis [PDF]
Journal of Biological Chemistry, 2002 Cancer cells display high rates of aerobic glycolysis, a phenomenon known historically as the Warburg effect. Lactate and pyruvate, the end products of glycolysis, are highly produced by cancer cells even in the presence of oxygen.
Huasheng Lu +2 more
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Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia [PDF]
Journal of Clinical Investigation, 2002 Under conditions of limited oxygen availability (hypoxia), multiple cell types release adenine nucleotides in the form of ATP, ADP, and AMP. Extracellular AMP is metabolized to adenosine by surface-expressed ecto-5'-nucleotidase (CD73) and subsequently ...
Kristin Synnestvedt +8 more
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Antioxidants, 2017 The importance of the tumor microenvironment for cancer progression and therapeutic resistance is an emerging focus of cancer biology. Hypoxia, or low oxygen, is a hallmark of solid tumors that promotes metastasis and represents a significant obstacle to
Rachel K. Toth, Noel A. Warfel
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Hypoxia-inducible factor-1 in tumour angiogenesis
World Journal of Gastroenterology, 2004 Hypoxia-inducible factor-1 (HIF-1), composed of HIF-alpha and HIF-beta subunits, is a heterodimeric transcriptional activator. In response to hypoxia, stimulation of growth factors, and activation of oncogenes as well as carcinogens, HIF-1alpha is overexpressed and/or activated and targets those genes which are required for angiogenesis, metabolic ...
Wei-Gang Fang, Yong-Hong Shi
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Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis [PDF]
Journal of Clinical Investigation, 2004 Mucosal epithelial cells are uniquely equipped to maintain barrier function even under adverse conditions. Previous studies have implicated hypoxia in mucosal tissue damage resulting from both acute and chronic inflammation.
Jörn Karhausen +5 more
semanticscholar +3 more sources
Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer
Frontiers in Oncology, 2017 Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers. Its canonical regulation involves prolyl hydroxylases (PHDs), which in
Luisa Iommarini +3 more
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Hypoxia induces autophagy in cardiomyocytes via a hypoxia-inducible factor 1-dependent mechanism
Experimental and Therapeutic Medicine, 2016 Hypoxia frequently accompanies such vascular disorders as atherosclerosis, thrombosis and ischemia/reperfusion injury. Myocardial ischemia/reperfusion, in particular, is a major contributor to cardiomyocyte impairment. Autophagy is a dynamic, self-catabolic process that has been implicated in a wide range of physiological processes and the pathogenesis
Guang Lv, Lan Gui, Batu Liu
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Cells, 2021 Hypoxia-inducible factor 1 can sufficiently control the progress of neurological symptoms after ischemic stroke owing to their actions associated with its downstream genes.
Nashwa Amin +10 more
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