Results 1 to 10 of about 120,663 (190)

Exenatide Is Neuroprotective in a New Rabbit Model of Hypoxia-Ischemia [PDF]

Cells
Hypoxia-ischemia is a serious perinatal complication affecting neonates globally. Animal models have increased the understanding of its pathophysiology and have been used to investigate potential therapies. Exenatide, clinically used for the treatment of
Eridan Rocha-Ferreira, Malin Carlsson, Pernilla Svedin, Kerstin Ebefors, Owen Herrock, Anna-Lena Leverin, Henrik Hagberg   +6 more
doaj   +2 more sources

MerTK and the Role of Phagoptosis in Neonatal Hypoxia-Ischemia [PDF]

Cells
Brain damage caused by hypoxia-ischemia is a serious complication for a newborn with possible life-long sequelae. To develop targeted neuroprotective strategies, it is essential to understand the mechanisms of injury, particularly the role of microglial ...
Andrea Jonsdotter, Henrik Hagberg, Anna-Lena Leverin, Joakim Ek, Kerstin Ebefors, Eridan Rocha-Ferreira, Ylva Carlsson   +6 more
doaj   +2 more sources

A Facile Route for the Preparation of Monodisperse Iron nitride at Silica Core/shell Nanostructures

Frontiers in Bioengineering and Biotechnology, 2021
Uniform-sized iron oxide nanoparticles obtained from the solution phase thermal decomposition of the iron-oleate complex were encapsulated inside the silica shell by the reverse microemulsion technique, and then thermal treatment under NH3 to transfer ...
Hoonsub Kim, Pyung Won Im, Pyung Won Im, Yuanzhe Piao, Yuanzhe Piao   +4 more
doaj   +1 more source

Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic–Ischemic Brain Injury in Neonatal Mice

ASN Neuro, 2023
A clinical challenge remains in the treatment of hypoxic–ischemic brain injury in newborns. Nicotinamide adenine dinucleotide (NAD + ) has beneficial effects in animal models of adult stroke.
Takuya Kawamura, Gagandeep Singh Mallah, Maryam Ardalan, Tetyana Chumak, Pernilla Svedin, Lina Jonsson, Seyedeh Marziyeh Jabbari Shiadeh, Fanny Goretta, Tomoaki Ikeda, Henrik Hagberg, Mats Sandberg, Carina Mallard   +11 more
doaj   +1 more source

Repurposed Edaravone, Metformin, and Perampanel as a Potential Treatment for Hypoxia–Ischemia Encephalopathy: An In Vitro Study

Biomedicines, 2022
Hypoxia–ischemia encephalopathy results from the interruption of oxygen delivery and blood flow to the brain. In the developing brain, it can lead to a brain injury, which is associated with high mortality rates and comorbidities.
Daniela Silva, Ruben Rocha, Ana Salomé Correia, Bárbara Mota, Maria Dulce Madeira, Nuno Vale, Armando Cardoso   +6 more
doaj   +1 more source

Involvement of the JNK/FOXO3a/Bim Pathway in Neuronal Apoptosis after Hypoxic-Ischemic Brain Damage in Neonatal Rats. [PDF]

, 2015
c-Jun N-terminal kinase (JNK) plays a key role in the regulation of neuronal apoptosis. Previous studies have revealed that forkhead transcription factor (FOXO3a) is a critical effector of JNK-mediated tumor suppression.
Li, Deyuan, Li, Jinhui, Li, Xihong, Mu, Dezhi, Qu, Yi, Tang, Jun, Wu, Jinlin, Xiong, Tao, Zhang, Li   +8 more
core   +5 more sources

δ-Opioid Receptors, microRNAs, and Neuroinflammation in Cerebral Ischemia/Hypoxia

Frontiers in Immunology, 2020
Hypoxia and ischemia are the main underlying pathogenesis of stroke and other neurological disorders. Cerebral hypoxia and/or ischemia (e.g., stroke) can lead to neuronal injury/death and eventually cause serious neurological disorders or even death in ...
Yi-Meng Chen, Xiao-Zhou He, Shu-Ming Wang, Ying Xia   +3 more
doaj   +1 more source

MiR-335 Regulates Hif-1α to Reduce Cell Death in Both Mouse Cell Line and Rat Ischemic Models. [PDF]

PLoS ONE, 2015
Hypoxia inducible factor-1α facilitates cellular adaptation to hypoxic conditions. Hence its tight regulation is crucial in hypoxia related diseases such as cerebral ischemia.
Fu Jia Liu, Prameet Kaur, Dwi S Karolina, Sugunavathi Sepramaniam, Arunmozhiarasi Armugam, Peter T H Wong, Kandiah Jeyaseelan   +6 more
doaj   +1 more source

Infratemporal fossa approach: the modified zygomatico-transmandibular approach

Maxillofacial Plastic and Reconstructive Surgery, 2019
Background The infratemporal fossa (ITF) is an anatomical lateral skull base space composed by the zygoma, temporal, and the greater wing of the sphenoid bone. Due to its difficult approach, surgical intervention at the ITF has remained a heavy burden to
Soung Min Kim, Sun Ha Paek, Jong Ho Lee
doaj   +1 more source

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic–Ischemic Brain Injury

Molecules, 2018
Neonatal hypoxia–ischemia is one of the main causes of mortality and disability of newborns. To study the mechanisms of neonatal brain cell damage, we used a model of neonatal hypoxia–ischemia in seven-day-old rats, by annealing of the common
Denis N. Silachev, Egor Y. Plotnikov, Irina B. Pevzner, Ljubava D. Zorova, Anastasia V. Balakireva, Mikhail V. Gulyaev, Yury A. Pirogov, Vladimir P. Skulachev, Dmitry B. Zorov   +8 more
doaj   +1 more source