Results 31 to 40 of about 120,663 (190)

Hypoxic Preconditioning Suppresses Glial Activation and Neuroinflammation in Neonatal Brain Insults

Mediators of Inflammation, 2015
Perinatal insults and subsequent neuroinflammation are the major mechanisms of neonatal brain injury, but there have been only scarce reports on the associations between hypoxic preconditioning and glial activation.
Chien-Yi Chen, Wei-Zen Sun, Kai-Hsiang Kang, Hung-Chieh Chou, Po-Nien Tsao, Wu-Shiun Hsieh, Wen-Mei Fu   +6 more
doaj   +1 more source

Effect of hypoxic preconditioning on brain genomic response before and following ischemia in the adult mouse: Identification of potential neuroprotective candidates for stroke

Neurobiology of Disease, 2006
The aim of the present study is to better understand oxygen-sensitive adaptative pathways underlying the hypoxic preconditioning-induced protection of the brain against ischemia.
Yang Tang, Emilie Pacary, Thomas Fréret, Didier Divoux, Edwige Petit, Pascale Schumann-Bard, Myriam Bernaudin   +6 more
doaj   +1 more source

PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia

JACC: Basic to Translational Science, 2023
Summary: Hypoxia-induced endothelial cell death and impaired angiogenesis are the main pathophysiological features of critical limb ischemia. Mechanistically, proprotein convertase subtilisin/kexin type 9 (PCSK9) promoted Smac translocation from ...
Meixin Zhang, MM, Yixi Chen, PhD, Yumin Qiu, PhD, Jiapan Sun, PhD, Jiang He, PhD, Zhefu Liu, MM, Jian Shi, PhD, Wenbin Wei, MD, Guifu Wu, PhD, Jianwen Liang, PhD   +9 more
doaj   +1 more source

Effects of therapeutic hypothermia on white matter injury from murine neonatal hypoxia-ischemia. [PDF]

, 2017
BackgroundTherapeutic hypothermia (TH) is the standard of care for neonates with hypoxic-ischemic encephalopathy, but it is not fully protective in the clinical setting.
Ferriero, Donna M, Koo, Elliot, Lee, Byong Sop, Sheldon, R Ann, Vexler, Zinaida S   +4 more
core   +2 more sources

Tetrahydrobiopterin in antenatal brain hypoxia-ischemia-induced motor impairments and cerebral palsy

Redox Biology, 2017
Antenatal brain hypoxia-ischemia, which occurs in cerebral palsy, is considered a significant cause of motor impairments in children. The mechanisms by which antenatal hypoxia-ischemia causes brain injury and motor deficits still need to be elucidated ...
Jeannette Vasquez-Vivar, Zhongjie Shi, Kehuan Luo, Karthikeyan Thirugnanam, Sidhartha Tan   +4 more
doaj   +1 more source

The spectrum of Ischemia-induced white matter injury varies with age [PDF]

, 2013
Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Muscat, Richard, Valentino, Mario, Zammit, Christian   +2 more
core   +1 more source

Subplate in a rat model of preterm hypoxia-ischemia. [PDF]

, 2014
OBJECTIVE: Hypoxia-ischemia (HI) in preterm infants primarily leads to injuries in the cerebral white matter. However, there is growing evidence that perinatal injury in preterms can also involve other zones including the cortical gray matter.
Ginet, V., Hoerder-Suabedissen, A., Matsuyama, T., Molnár, Z., Oeschger, F., Okusa, C., Truttmann, A.C., Wang, W.Z.   +7 more
core   +1 more source

Tannic Acid Improves Renal Function Recovery after Renal Warm Ischemia–Reperfusion in a Rat Model

Biomolecules, 2020
Background and purpose: Ischemia−reperfusion injury is encountered in numerous processes such as cardiovascular diseases or kidney transplantation; however, the latter involves cold ischemia, different from the warm ischemia found in vascular ...
Louise Alechinsky, Frederic Favreau, Petra Cechova, Sofiane Inal, Pierre-Antoine Faye, Cecile Ory, Raphaël Thuillier, Benoit Barrou, Patrick Trouillas, Jerome Guillard, Thierry Hauet   +10 more
doaj   +1 more source

Dying neurons in thalamus of asphyxiated term newborns and rats are autophagic. [PDF]

, 2014
OBJECTIVE: Neonatal hypoxic-ischemic encephalopathy (HIE) still carries a high burden by its mortality and long-term neurological morbidity in survivors. Apart from hypothermia, there is no acknowledged therapy for HIE, reflecting the lack of mechanistic
Adhami, Alkayed, Borsello, Clarke, Clarke, Denton, Dong, Edwards, Gao, Ginet, Ginet, Grishchuk, Hurn, Ichimura, Klionsky, Koike, Krageloh-Mann, Kroemer, Kuma, Lang, Liang, Liu, Luciani, Matyja, Miller, Mizushima, Nakajima, Nitatori, Northington, Northington, Northington, Okereafor, Piras, Portera-Cailliau, Puyal, Puyal, Puyal, Rami, Renolleau, Rice, Romijn, Rutherford, Samara, Sarnat, Shacka, Sheldon, Takizawa, Turtzo, Vagnerova, Vries, Wang, Wen, Xing, Xue, Zhang, Zhu, Zhu   +56 more
core   +1 more source

Neuronal vulnerability to fetal hypoxia-reoxygenation injury and motor deficit development relies on regional brain tetrahydrobiopterin levels

Redox Biology, 2020
Hypertonia is pathognomonic of cerebral palsy (CP), often caused by brain injury before birth. To understand the early driving events of hypertonia, we utilized magnetic resonance imaging (MRI) assessment of early critical brain injury in rabbit fetuses (
Jeannette Vasquez-Vivar, Zhongjie Shi, Jeong-Won Jeong, Kehuan Luo, Amit Sharma, Karthikeyan Thirugnanam, Sidhartha Tan   +6 more
doaj   +1 more source