Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. [PDF]
, 2013 A long-standing controversy is whether autophagy is a bona fide cause of mammalian cell death. We used a cell-penetrating autophagy-inducing peptide, Tat-Beclin 1, derived from the autophagy protein Beclin 1, to investigate whether high levels of ...
Clarke, P.G. +13 more
core +1 more source
Complex pattern of interaction between in utero hypoxia-ischemia and intra-amniotic inflammation disrupts brain development and motor function [PDF]
, 2014 Background: Infants born preterm commonly suffer from a combination of hypoxia-ischemia (HI) and infectious perinatal inflammatory insults that lead to cerebral palsy, cognitive delay, behavioral issues and epilepsy.
Berglass, Jacqueline +6 more
core +1 more source
Neonatal Mice Lacking Neuronal Nitric Oxide Synthase Are Less Vulnerable to Hypoxic–Ischemic Injury
Neurobiology of Disease, 1996 We hypothesized that elimination of neuronal nitric oxide synthase (nNOS) by targeted disruption of the nNOS gene would result in amelioration of damage seen after hypoxia–ischemia in the developing brain since nitric oxide (NO) has been implicated in ...
Donna M. Ferriero +3 more
doaj +1 more source
Involvement of autophagy in hypoxic-excitotoxic neuronal death. [PDF]
, 2014 Neuronal autophagy is increased in numerous excitotoxic conditions including neonatal cerebral hypoxia-ischemia (HI). However, the role of this HI-induced autophagy remains unclear.
Clarke, P.G. +8 more
core +2 more sources
Delayed neural network degeneration after neonatal hypoxia‐ischemia [PDF]
Annals of Neurology, 2008 AbstractObjectiveClinical magnetic resonance studies show delayed and ongoing neurodegeneration after neonatal hypoxia‐ischemia (HI), but the mechanisms and timing of this neurodegeneration remain unclear. We used ex vivo diffusion tensor imaging (DTI) and brain neuropathology to determine whether selective injury to white matter tracts occurs after ...
Brian S, Stone +5 more
openaire +2 more sources
Xa inhibitor edoxaban ameliorates hepatic ischemia-reperfusion injury via PAR-2-ERK 1/2 pathway.
PLoS ONEHepatic ischemia-reperfusion injury causes liver damage during surgery. In hepatic ischemia-reperfusion injury, the blood coagulation cascade is activated, causing microcirculatory incompetence and cellular injury.
Koki Maeda +11 more
doaj +1 more source
Cardiac Shock Wave Therapy Attenuates H9c2 Myoblast Apoptosis by Activating the AKT Signal Pathway
Cellular Physiology and Biochemistry, 2014 Background: Previous studies have demonstrated that Cardiac Shock Wave Therapy (CSWT) improves myocardial perfusion and cardiac function in a porcine model of chronic myocardial ischemia and also ameliorates myocardial ischemia in patients with severe ...
Weiwei Yu +7 more
doaj +1 more source
Inhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of asphyxia induced-cardiac arrest. [PDF]
, 2019 Cognitive deficits are a devastating neurological outcome seen in survivors of cardiac arrest. We previously reported water electrolysis derived 67% hydrogen gas inhalation has some beneficial effects on short-term outcomes in a rat model of global brain
Alexander +32 more
core +2 more sources
Bax shuttling after neonatal hypoxia–ischemia: Hyperoxia effects [PDF]
Journal of Neuroscience Research, 2008 AbstractPerinatal hypoxia–ischemia (HI) occurs in 0.2%–0.4% of all live births, with 100% O2 resuscitation (HHI) remaining a standard clinical treatment. HI produces a broad spectrum of neuronal death phenotypes ranging from a more noninflammatory apoptotic death to a more inflammatory necrotic cell death that may be responsible for the broad spectrum ...
Martin B, Gill +3 more
openaire +2 more sources
Neural Regeneration Research, 2016 Heat shock protein 70 (HSP70) maintains Ca2+ homeostasis in PC12 cells, which may protect against apoptosis; however, the mechanisms of neuroprotection are unclear.
Yuan Liu +6 more
doaj +1 more source