Results 51 to 60 of about 120,663 (190)

Overexpression of miR-92a attenuates kidney ischemia–reperfusion injury and improves kidney preservation by inhibiting MEK4/JNK1-related autophagy

open access: yesCellular & Molecular Biology Letters, 2023
Background Kidney ischemia–reperfusion injury is inevitable in kidney transplantation, and is essential for primary graft dysfunction and delayed graft function.
Ming Ma   +4 more
doaj   +1 more source

Hypoxia-ischemia and retinal ganglion cell damage

open access: yesClinical Ophthalmology, 2008
Retinal hypoxia is the potentially blinding mechanism underlying a number of sight-threatening disorders including central retinal artery occlusion, ischemic central retinal vein thrombosis, complications of diabetic eye disease and some types of glaucoma. Hypoxia is implicated in loss of retinal ganglion cells (RGCs) occurring in such conditions.
Charanjit Kaur   +2 more
openaire   +4 more sources

The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia [PDF]

open access: yesDevelopmental Neuroscience, 2018
Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms.
Jana Krystofova   +4 more
openaire   +4 more sources

Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography [PDF]

open access: yes, 2011
Accurate identification of ischemic penumbra will improve stroke patient selection for reperfusion therapies and clinical trials. Current magnetic resonance imaging (MRI) techniques have limitations and lack validation.
Barrie Condon   +9 more
core   +1 more source

Splenic Immune Cells in Experimental Neonatal Hypoxia–Ischemia [PDF]

open access: yesTranslational Stroke Research, 2012
Neuroimmune processes contribute to hypoxic-ischemic damage in the immature brain and may play a role in the progression of particular variants of neonatal encephalopathy. The present study was designed to elucidate molecular mediators of interactions between astrocytes, neurons and infiltrating peripheral immune cells after experimental neonatal ...
Nancy, Fathali   +5 more
openaire   +2 more sources

Effect of neonatal asphyxia on the impairment of the auditory pathway by recording auditory brainstem responses in newborn piglets: a new experimentation model to study the perinatal hypoxic-ischemic damage on the auditory system.

open access: yesPLoS ONE, 2015
IntroductionHypoxia-ischemia (HI) is a major perinatal problem that results in severe damage to the brain impairing the normal development of the auditory system.
Francisco Jose Alvarez   +9 more
doaj   +1 more source

The immune response after hypoxia-ischemia in a mouse model of preterm brain injury [PDF]

open access: yes, 2014
Background: Preterm brain injury consists primarily of periventricular leukomalacia accompanied by elements of gray-matter injury, and these injuries are associated with cerebral palsy and cognitive impairments.
Albertsson, Anna-Maj   +11 more
core   +2 more sources

Vulnerability of the Developing Brain to Hypoxic-Ischemic Damage: Contribution of the Cerebral Vasculature to Injury and Repair?

open access: yesFrontiers in Physiology, 2012
As clinicians attempt to understand the underlying reasons for the vulnerability of different regions of the developing brain to injury, it is apparent that little is known as to how hypoxia-ischemia may affect the cerebrovasculature in the developing ...
Ana eBaburamani   +5 more
doaj   +1 more source

Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy. [PDF]

open access: yes, 2017
Global patterns of brain injury correlate with motor, cognitive, and language outcomes in survivors of neonatal encephalopathy (NE). However, it is still unclear whether local changes in brain structure predict specific deficits.
Barkovich, A James   +9 more
core   +2 more sources

Platelet Lysate Therapy Attenuates Hypoxia Induced Apoptosis in Human Uroepithelial SV-HUC-1 Cells through Regulating the Oxidative Stress and Mitochondrial-Mediated Intrinsic Apoptotic Pathway

open access: yesBiomedicines, 2023
(1) Background: Ischemia/hypoxia plays an important role in interstitial cystitis/bladder pain syndrome (IC/BPS). Platelet-rich plasma (PRP) has been shown to relieve symptoms of IC/BPS by regulating new inflammatory processes and promoting tissue repair.
Zong-Sheng Wu   +5 more
doaj   +1 more source

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