Results 101 to 110 of about 618,162 (164)

The evolving role of immunotherapy in ovarian cancer

Cancer, Volume 132, Issue 18, 15 September 2026.
Abstract Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoint inhibitors have transformed treatment in other solid tumors, their activity in ovarian cancer has been limited by tumor heterogeneity, an immunosuppressive tumor microenvironment, and the lack of robust predictive biomarkers.
Ana Carolina Veneziani, Laura Venegas, Amit M. Oza   +2 more
wiley   +1 more source

Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors. [PDF]

ACS Med Chem Lett, 2021
Cherney EC, Zhang L, Guo W, Huang A, Williams D, Seitz S, Shan W, Zhu X, Gullo-Brown J, Maley D, Lin TA, Hunt JT, Huang C, Yang Z, D'Arienzo CJ, Discenza LN, Ranasinghe A, Grubb MF, Traeger SC, Li X, Johnston KA, Kopcho L, Fereshteh M, Foster KA, Stefanski K, Delpy D, Dhar G, Anandam A, Mahankali S, Padmanabhan S, Rajanna P, Murali V, Mariappan TT, Pattasseri S, Nimje RY, Hong Z, Kempson J, Rampulla R, Mathur A, Gupta A, Borzilleri R, Vite G, Balog A.   +42 more
europepmc   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Az indolamin-2,3-dioxigenáz-1 (IDO1) enzim farmakogenomikai vizsgálata humán tumorokban

Az indolamin-2,3-dioxigenáz-1 (IDO1) enzim a triptofán (Trp) lebontás első, sebességmeghatározó lépését katalizálja. A magas IDO1 szintnek, illetve a Trp metabolitok megnövekedett szintjének immunmoduláló és immunszuppresszív hatása van.
Hornyák, Anna
core  

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Unraveling the Anti‐Arthritic Potential of Bioactive Compounds From Melaleuca alternifolia Oil: Integrated In Vivo, Molecular Docking, and Network Pharmacology Insights

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Melaleuca alternifolia oil demonstrated significant anti‐arthritic effects in CFA‐induced rats by reducing paw edema, PGE2 levels, and inflammatory biomarkers. It improved hematological and histopathological parameters, modulated cytokine expression, and showed promising phytochemical‐target interactions through GC–MS, network pharmacology, and ...
Sana Sabir, Aisha Mobashar, Hossam Kamli, Hafiza Mahnoor Baghdadi, Bushra Akhtar, Amir Ali, Sana Saleem, Khalid Hussain, Kiran Mashaal, Esmael M. Alyami, Mona Alsolami, Fakhreldeen Dabiellil, Pravin Badhe, Gehan M. Elossaily, Muhammad Shahab, Abdel‐Rhman Z. Gaafar   +15 more
wiley   +1 more source

Divergent Clonal Trajectories of FLT3‐ITD in Acute Myeloid Leukemia and Their Clinical and Transcriptomic Associations

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT FLT3‐ITD occurs in approximately 20%–25% of cases of adult AML and is associated with increased relapse risk and shorter survival. FLT3‐ITD status informs AML risk at diagnosis, but its dynamic changes during disease evolution are not well defined.
Xavier Cheng‐Hong Tsai, Yu‐Sung Chang, Feng‐Ming Tien, Min‐Yen Lo, Yuan‐Yeh Kuo, Mei‐Hsuan Tseng, Yen‐Ling Peng, Chi‐Yuan Yao, Szu‐Chi Yao, Chien‐Chin Lin, Bor‐Sheng Ko, Ming Yao, Hwei‐Fang Tien, Hsin‐An Hou, Wen‐Chien Chou   +14 more
wiley   +1 more source

Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors. [PDF]

ACS Med Chem Lett, 2021
Li D, Deng Y, Achab A, Bharathan I, Hopkins BA, Yu W, Zhang H, Sanyal S, Pu Q, Zhou H, Liu K, Lim J, Fradera X, Lesburg CA, Lammens A, Martinot TA, Cohen RD, Doty AC, Ferguson H, Nickbarg EB, Cheng M, Spacciapoli P, Geda P, Song X, Smotrov N, Abeywickrema P, Andrews C, Chamberlin C, Mabrouk O, Curran P, Richards M, Saradjian P, Miller JR, Knemeyer I, Otte KM, Vincent S, Sciammetta N, Pasternak A, Bennett DJ, Han Y.   +39 more
europepmc   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source