Results 211 to 220 of about 28,037,829 (342)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

IL-1 Pathway Inhibition in Recurrent Pericarditis Management: Real-World Adoption of Corticosteroid Sparing in RESONANCE. [PDF]

JACC Adv
Cremer PC, Luis SA, Garshick MS, Raisinghani A, Weber B, Winnowski D, Clair J, Parameswaran V, Curtis A, Klein AL, Paolini JF, RESONANCE Study Group.   +11 more
europepmc   +1 more source

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

Proceedings of the National Academy of Sciences of the United States of America, 2014
A. De Luca, S. Smeekens, A. Casagrande, R. Iannitti, K. Conway, M. Gresnigt, J. Begun, T. Plantinga, L. Joosten, J. V. D. van der Meer, Georgios Chamilos, M. Netea, R. Xavier, C. Dinarello, L. Romani, F. L. van de Veerdonk   +15 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bone marrow-derived emergency monopoiesis drives brain-lung axis injury after traumatic brain injury via IL-1. [PDF]

J Neuroinflammation
Ma T, Liu J, Gao Z, Li Y, Lin J, Pang K, Li R, Zhang X, Tang L, Liu Y, Zhang H, Zhang Y, Cai LC, Zhou Z, Shi K, Zhu T, Zhang J, Chen J, Cai Z, Fu Y, Zhao Z.   +20 more
europepmc   +1 more source

LPS and IL‐1 differentially activate mouse and human astrocytes: Role of CD14

Glia, 2014
L. Tarassishin, Hyeon-sook Suh, Sunhee C. Lee   +2 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

IL-1 Receptor Antagonist Antibodies in Idiopathic Recurrent Pericarditis.

JAMA Netw Open
Wu MA, Kessel C, Fadle N, Regitz E, Fuehner S, Negro E, Berra S, Pfeifer J, Ceriani E, Thurner B, Klingel K, Caforio A, Imazio M, Brucato A, Thurner L.   +14 more
europepmc   +1 more source

Comparison of IgG4 with inflammatory cytokines (IL-1, IL-6 and TNFα) in rheumatoid arthritis. [PDF]

Front Immunol
Sakthiswary R, Shaharir S, Abdul Wahab A, Uma Rajeswaran V.   +3 more
europepmc   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source