Results 1 to 10 of about 1,658,316 (194)

Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs. [PDF]

Sci Rep
Ho GW, Santos A, Fields J, Rosato PC, Turk MJ, Steinmetz NF, Fiering S.   +6 more
europepmc   +1 more source

Genetic variant rs2243115 of the IL-12/IL-35 pathway contributes to the risk of coronary artery disease. [PDF]

Int J Med Sci
Chen Q, Zhang W, Xie T, Dong J, Zhang J, Zha L.   +5 more
europepmc   +1 more source

Preclinical and clinical evaluation of intratumoral injection of an IL-12 expressing SKV-012 oncolytic virus for advanced solid tumors. [PDF]

J Immunother Cancer
Jiang Z, Yang N, Jin J, Zhang Z, Lu H, Xu L, Chen Y, Jin L, Zhou L, Yang H, Liu J, Zhang W, Tong A, Peng X.   +13 more
europepmc   +1 more source

IL-12 minicircle delivery via extracellular vesicles as immunotherapy for bladder cancer. [PDF]

Cell Prolif
Wu Z, Li W, Tan M, How FYX, Sadhasivan H, Mahendran R, Wu Q, Chiong E, Le MTN.   +8 more
europepmc   +1 more source

Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist

European Journal of Immunology, 1995
AbstractInterleukin‐12 (IL‐12) is a cytokine that has regulatory effects on T and natural killer (NK) cells and is composed of two disulfide‐bonded subunits, p40 and p35. It was recently reported that supernatants from cultures of mouse IL‐12 (moIL‐12) p40‐transfected COS cells could inhibit IL‐12‐dependent responses in vitro (Mattner, F., et al., Eur.
Gillessen Sommer, Silke, Carvajal, D, Ling, P, Podlaski, F.J, Stremlo, D.L, Familletti, P.C, Gubler, U, Presky, D.H, Stern, A.S, Gately, M.K   +9 more
openaire   +3 more sources

IL-12 ELISPOT ASSAYS TO DETECT AND ENUMERATE IL-12 SECRETING CELLS

Cytokine, 2000
The cytokine IL-12 promotes Th(1)type immune responses and plays a key role in immune regulation. The complex nature of IL-12 hampered its detection without use of stimulants that might give less relevant information. To detect circulating IL-12 p40, we developed enzyme-linked immunospot (ELISPOT) assays that allow enumeration of IL-12 p40 secreting ...
Ozenci, V, Kouwenhoven, M, Press, R, Link, H, Huang, Y M   +4 more
openaire   +4 more sources

Nanocapsule Delivery of IL-12

2020
Interleukin(IL)-12 is a protein that activates T cells and macrophages to kill tumor cells. However, despite this cytokine showing strong antitumor activity in preclinical settings, translation to patients has been slowed by toxic side effects, poor distribution to peripheral tissues, and improper dosing regimens.
Justin E, Markel, Ryan A, Lacinski, Brock A, Lindsey   +2 more
openaire   +2 more sources

Delivery of IL-12 intranasally leads to reduced IL-12-mediated toxicity

International Immunopharmacology, 2003
Interleukin-12 (IL-12) is a heterodimeric cytokine that enhances immune responses to bacterial, parasitic, and viral pathogens, and leads to tumor regression in animal models. For this reason, the use of IL-12 as a vaccine adjuvant and as a therapeutic agent for the treatment of cancer is being investigated.
Victor C, Huber, Bernard P, Arulanandam, Paul M, Arnaboldi, Monica K, Elmore, Christine E, Sheehan, Bhaskar V S, Kallakury, Dennis W, Metzger   +6 more
openaire   +2 more sources

Prostaglandin E2 and Dexamethasone Inhibit IL-12 Receptor Expression and IL-12 Responsiveness

The Journal of Immunology, 1998
AbstractRegulation of the factors governing IL-12R expression and IL-12 responsiveness has been shown to be important in the generation and stability of Th1- and Th2-type responses. In this regard, cytokines have been shown to have a prominent role in regulating IL-12R expression.
C Y, Wu, K, Wang, J F, McDyer, R A, Seder   +3 more
openaire   +2 more sources

Biology of IL-12

2016
Interleukin 12 (IL-12) is a heterodimeric, multifunctional cytokine, the actions of which orchestrate activities of innate and adaptive immunity, partially due to a potent stimulation of IFN-γ production from T lymphocytes and natural killer (NK) cells.
Radoslaw Zagozdzon, Witold Lasek
openaire   +2 more sources