Results 171 to 180 of about 1,816,357 (289)

T cell and cytokine signatures as early predictors of response to IL-12/IL-23 inhibition in Crohn's disease. [PDF]

Front Immunol
Martín Arranz E, García-Ramirez L, Van Den Rym A, Suarez C, García-Solís B, Díaz-Iglesias N, López-Lera A, Corvillo F, Rueda García JL, Blanco-San Miguel P, Sánchez Azofra M, Poza Cordón J, Itan Y, López-Collazo E, Pérez de Diego R, Martín-Arranz MD.   +15 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Combination of Vaccine With IL-12-Armed Oncolytic Virus SKV-012 Synergistically Potentiates Immune Responses in HPV-Associated Malignancies. [PDF]

MedComm (2020)
Yang N, Xu L, Zheng M, Lu H, Chen Y, Zhu Z, Zeng W, Wang Z, Li H, Li J, Jiang Z, Zeng P, Wang G, Xie H, Zhang Z, Yang H, Tong A.   +16 more
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Advanced electrotransfer for IL-12 gene immunotherapy in melanoma: Challenges and possibilities. [PDF]

Mol Ther Oncol
Niwa Y, Igarashi J.
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

IL-12 as a Potential Prognostic Marker in Penile Cancer: Implications for Immune Dysregulation. [PDF]

Int J Mol Sci
Czajkowski M, Kunc M, Kieżun J, Kraziński BE, Matuszewski M, Łyzińska W, Hakenberg OW, Wierzbicki PM.   +7 more
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer. [PDF]

Nat Mater
Pires IS, Covarrubias G, Gomerdinger VF, Backlund C, Nombera Bueno E, Billingsley MM, Pryor M, Shanker A, Gordon E, Wu S, Pickering AJ, Melo MB, Suh H, Irvine DJ, Hammond PT.   +14 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source