Results 251 to 260 of about 1,816,357 (289)

A time-gated PKA-CREB signaling circuit licenses IL-12 responsiveness and Th1 fate in CD4⁺ T cells. [PDF]

Proc Natl Acad Sci U S A
Zhao J, Dainichi T, Guichard V, Zhang Y, Shirley S, Leão FB, Tian R, Huang Y, Ghosh S.   +8 more
europepmc   +1 more source

IL-12 mRNA-LNP promotes dermal resident memory CD4⁺ T cell development. [PDF]

NPJ Vaccines
Zabala-Peñafiel A, Gonzalez-Lombana C, Alameh MG, Sacramento LA, Mou Z, Phan AT, Aunins EA, Tam YK, Uzonna JE, Weissman D, Hunter CA, Scott P.   +11 more
europepmc   +1 more source

CARG-2020 targets IL-12, IL-17, and PD-L1 pathways to effectively treat melanoma and breast cancer. [PDF]

Sci Rep
Ahmadi E, Chiari C, Madina BR, Yarovinsky TO, Krady MM, Chen J, Almassian B, Nakaar V, Wang K.   +8 more
europepmc   +1 more source

The role of IFN-γ + 874T/A and IL-12 + 16974A/C polymorphisms in susceptibility to tuberculosis infection in a Sudanese population: a case-control study. [PDF]

BMC Infect Dis
Moharrum SA, Bilal NE, Mhmoud NA.
europepmc   +1 more source

A quadral biosignature of IFN-γ, IL-2, IL-12 and IP-10 increases the diagnostic potential for latent tuberculosis among diabetic patients in Uganda. [PDF]

BMC Immunol
Ssekamatte P, Sitenda D, Nabatanzi R, Nakibuule M, Kibirige D, Kyazze AP, Kateete DP, Bagaya BS, Sande OJ, van Crevel R, Cose S, Biraro IA.   +11 more
europepmc   +1 more source

Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ. [PDF]

Cell Host Microbe
Eislmayr KD, Nichols CA, Liu FL, Yuvaraj S, Babirye JP, Roncaioli JL, Vickery J, Barton GM, Lesser CF, Vance RE.   +9 more
europepmc   +1 more source

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IL-12 ELISPOT ASSAYS TO DETECT AND ENUMERATE IL-12 SECRETING CELLS

Cytokine, 2000
The cytokine IL-12 promotes Th(1)type immune responses and plays a key role in immune regulation. The complex nature of IL-12 hampered its detection without use of stimulants that might give less relevant information. To detect circulating IL-12 p40, we developed enzyme-linked immunospot (ELISPOT) assays that allow enumeration of IL-12 p40 secreting ...
Ozenci, V, Kouwenhoven, M, Press, R, Link, H, Huang, Y M   +4 more
openaire   +3 more sources

Nanocapsule Delivery of IL-12

2020
Interleukin(IL)-12 is a protein that activates T cells and macrophages to kill tumor cells. However, despite this cytokine showing strong antitumor activity in preclinical settings, translation to patients has been slowed by toxic side effects, poor distribution to peripheral tissues, and improper dosing regimens.
Justin E, Markel, Ryan A, Lacinski, Brock A, Lindsey   +2 more
openaire   +2 more sources

Delivery of IL-12 intranasally leads to reduced IL-12-mediated toxicity

International Immunopharmacology, 2003
Interleukin-12 (IL-12) is a heterodimeric cytokine that enhances immune responses to bacterial, parasitic, and viral pathogens, and leads to tumor regression in animal models. For this reason, the use of IL-12 as a vaccine adjuvant and as a therapeutic agent for the treatment of cancer is being investigated.
Victor C, Huber, Bernard P, Arulanandam, Paul M, Arnaboldi, Monica K, Elmore, Christine E, Sheehan, Bhaskar V S, Kallakury, Dennis W, Metzger   +6 more
openaire   +2 more sources

Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist

European Journal of Immunology, 1995
AbstractInterleukin‐12 (IL‐12) is a cytokine that has regulatory effects on T and natural killer (NK) cells and is composed of two disulfide‐bonded subunits, p40 and p35. It was recently reported that supernatants from cultures of mouse IL‐12 (moIL‐12) p40‐transfected COS cells could inhibit IL‐12‐dependent responses in vitro (Mattner, F., et al., Eur.
S, Gillessen, D, Carvajal, P, Ling, F J, Podlaski, D L, Stremlo, P C, Familletti, U, Gubler, D H, Presky, A S, Stern, M K, Gately   +9 more
openaire   +2 more sources