Results 261 to 270 of about 1,816,357 (289)

Prostaglandin E2 and Dexamethasone Inhibit IL-12 Receptor Expression and IL-12 Responsiveness

The Journal of Immunology, 1998
Abstract Regulation of the factors governing IL-12R expression and IL-12 responsiveness has been shown to be important in the generation and stability of Th1- and Th2-type responses. In this regard, cytokines have been shown to have a prominent role in regulating IL-12R expression.
C Y, Wu, K, Wang, J F, McDyer, R A, Seder   +3 more
openaire   +2 more sources

Cloning and expression of murine IL-12

The Journal of Immunology, 1992
Abstract Human IL-12 (NK cell stimulatory factor, cytotoxic lymphocyte maturation factor) is a heterodimeric cytokine that can act as a growth factor for activated human T and NK cells, enhance the lytic activity of human NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting human PBMC. Because in our
D S, Schoenhaut, A O, Chua, A G, Wolitzky, P M, Quinn, C M, Dwyer, W, McComas, P C, Familletti, M K, Gately, U, Gubler   +8 more
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Impact of IL-12 in Cancer

Current Cancer Drug Targets, 2017
Interleukin 12 (IL-12) is a pleiotropic cytokine that plays an essential role in Th1-type immune response against cancer, a condition where cells in a particular part of the body grow and reproduce uncontrollably.In this review, we describe the structural features of IL-12 family and their roles involved in cancer.IL-12 has been demonstrated to ...
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IL-12 Is a Heparin-Binding Cytokine

The Journal of Immunology, 1999
Abstract Using an ELISA approach, we demonstrate that recombinant human IL-12 (rhIL-12) binds strongly to an immobilized heparin-BSA complex. This binding is completely displaceable with soluble heparin, IC50∼ 0.1 μg/ml, corresponding to ∼ 10 nM.
M, Hasan, S, Najjam, M Y, Gordon, R V, Gibbs, C C, Rider   +4 more
openaire   +2 more sources

Biology of IL-12

2016
Interleukin 12 (IL-12) is a heterodimeric, multifunctional cytokine, the actions of which orchestrate activities of innate and adaptive immunity, partially due to a potent stimulation of IFN-γ production from T lymphocytes and natural killer (NK) cells.
Radoslaw Zagozdzon, Witold Lasek
openaire   +2 more sources

Inhibition of IL-12 production by thalidomide

The Journal of Immunology, 1997
Abstract The immunomodulatory properties of thalidomide are currently being exploited therapeutically in conditions as diverse as erythema nodosum leprosum, chronic graft-vs-host disease, rheumatoid arthritis, and sarcoidosis. The relevant mechanism of action of thalidomide in these diseases remains unclear.
D R, Moller, M, Wysocka, B M, Greenlee, X, Ma, L, Wahl, D A, Flockhart, G, Trinchieri, C L, Karp   +7 more
openaire   +2 more sources

Complement and IL-12: yin and yang

Microbes and Infection, 2001
Interleukin 12 (IL-12) is central to the orchestration of cell-mediated immune responses in the innate as well as the adaptive immune system. Recent studies of the pathogenesis of diseases as disparate as measles and asthma have suggested that the complement system, itself at the interface of innate and adaptive immunity, is a biologically relevant ...
C L, Karp, M, Wills-Karp
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Expression of IL-12 Receptor by Neurons

Viral Immunology, 2004
Interleukin (IL)-12, a key cytokine bridging innate and acquired immunity, is efficacious in enhancing recovery from experimental vesicular stomatitis virus (VSV) infection of the mouse central nervous system (CNS). This response is associated with the upregulation of neuronal nitric oxide synthase (NOS-1), independent of IFN-gamma and TNF-alpha.
Derek D C, Ireland, Carol Shoshkes, Reiss   +1 more
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Analysis of the Multiple Interactions Between IL-12 and the High Affinity IL-12 Receptor Complex

The Journal of Immunology, 1998
Abstract IL-12 is a heterodimeric cytokine, composed of a p40 and a p35 subunit, that exerts its biological effects by binding to specific cell surface receptors. Two IL-12R proteins, designated human IL-12 (huIL-12) receptor β1 (huIL-12Rβ1) and huIL-12Rβ2, have been previously identified.
D H, Presky, L J, Minetti, S, Gillessen, V L, Wilkinson, C Y, Wu, U, Gubler, R, Chizzonite, M K, Gately   +7 more
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Characterization of anti-mouse IL-12 monoclonal antibodies and measurement of mouse IL-12 by ELISA

Journal of Immunological Methods, 1996
Enzyme-linked immunosorbent assays (ELISAs) capable of quantitatively measuring pg/ml amounts of mouse IL-12 (moIL-12) were developed as an alternative to the current bioassay procedure used for the measurement of moIL-12. A panel of 40 rat anti-moIL-12 monoclonal antibodies were identified and tested for their ability to bind 125I-moIL-12.
V L, Wilkinson, R R, Warrier, T P, Truitt, P, Nunes, M K, Gately, D H, Presky   +5 more
openaire   +2 more sources