Results 81 to 90 of about 69,683,828 (280)

Sequential intravesical instillation of epirubicin and il-15/il-15rα enhances antitumor efficacy in orthotopic bladder cancer through immunogenic cell death and cd8+ T cell-dependent immune activation [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
This study aimed to investigate whether sequential intravesical instillation of epirubicin (EPI) followed by interleukin-15 (IL-15)/interleukin-15 receptor alpha (IL-15Rα) could integrate cytotoxic and immune-stimulatory effects for improved antitumor ...
Jiawei MA, Shichao WEI, Feifei PAN
doaj   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Skeletal Muscle, Myokines and Health

Medicine Science, 2012
There is accumulating epidemiological evidence that a physically active life plays an independent role in the protection against metabolic syndrome, type 2 diabetes, cardiovascular diseases, cancer, and dementia. For most of the last century, researchers
Halil Duzova
doaj   +1 more source

Infection of ENU mutant mice with Human Herpes Simplex Virus-1 (HSV-1) to investigate the effects of IL-15 splice variant on CD8+ T cell-mediated immunity

, 2010
介白質-15（interleukin-15，IL-15）是細胞激素的一種。除了參與免疫反應之外，同時也對體內其他生理機能扮演重要的角色，像是骨骼肌的代謝及角質細胞的增生。由於IL-15的作用廣泛，因此其表達在轉錄、轉譯及胞內運送的階段都被嚴密地調控。同時IL-15被發現有多種選擇性剪接異構體存在，除了對IL-15的分泌影響外，目前對於IL-15選擇性剪接異構體對於IL-15本身的調控及影響仍不清楚。在我們的研究中，利用國家型基因突變鼠核心實驗室以ENU誘導突變所建立的突變鼠品系191(p191 ...
Chang, Ping-Fang, 張萍芳
core  

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source

“We Cannot Talk as a Family”: Complexities of Survivorship Communication Among Hispanic/Latino Young Adult Survivors of Childhood Cancer, Parents, and Clinicians

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Young adult childhood cancer survivors (YA‐CCS) have an increased risk of treatment‐related health complications throughout their lives. Lifelong survivorship care is recommended, yet many YA‐CCS experience disruptions in care during pediatric‐to‐adult transitions and do not receive recommended survivorship care.
Kevin Shanchen Pu, Nicole Fernández‐Viña, Briana C. Martin‐Villa, Daniela Ramirez, Rebecca M. Lewinsohn, Mary Smith, Heidi Boynton, Lidia Schapira, Stephanie M. Smith   +8 more
wiley   +1 more source

IL-15 MΦ and IL-10 MΦ differentially respond to M. leprae infection.

, 2018
IL-15 MΦ and IL-10 MΦ were infected with M. leprae or stimulated with TLR2L for 24 hours. (A) CYP27B1 and (B) OAS1 gene expression levels were assayed by quantitative PCR. (C) IL-15 MΦ were infected with M.
Carter A. Gottlieb (5832251), John S. Adams (186772), Rosane M. Teles (5832254), Kathryn Zavala (5832248), Philip T. Liu (263145), Martin Hewison (23442), Robert L. Modlin (263161)   +6 more
core   +1 more source

Identifying Patterns of Hospitalizations Among Childhood Cancer Survivors: A Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood cancer survivors (CCSs) experience more hospitalizations than the general population. We aimed to identify distinct hospitalization patterns among Queensland CCSs and the associated characteristics. Methods Cases (aged ≤14 years) diagnosed between 1995 and 2019 while residents of Queensland were identified through the ...
Hai Pham, Teyl Engstrom, Peter Baade, Natalie Bradford, Sarah Pont, Louise Marquart‐Wilson, Natasha Nassar, Jason D. Pole   +7 more
wiley   +1 more source

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Effects of IL-2 and IL-15 on CTL migration.

, 2013
IL-2 (500 u/ml), IL-15 (100 ng/ml), or the combination of IL-2/IL-15 was added into the fibrin clots (Formulation 1). ATP assays were performed to quantify the number of T cells that had migrated out of the clots after 24, 48, and 96 hours.
Erin Denny (327372), Josh Neman (327375), Michael C. Jensen (327373), Rahul Jandial (327376), Zhaoxia Zou (327371), Mike Chen (327379), Tatsuhiro Fujii (327374), Gang Li (34549), Christine E. Brown (167785)   +8 more
core   +1 more source