Results 61 to 70 of about 2,851 (168)

Interleukin-18 in Inflammatory Kidney Disease

Frontiers in Medicine, 2021
Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is structurally similar to IL-1β. IL-18 promotes the production of interferon gamma (IFN-γ) and strongly induces a Th1 response.
Yasuaki Hirooka, Yuji Nozaki
doaj   +1 more source

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD [PDF]

, 2013
Background In models of COPD, environmental stressors induce innate immune responses, inflammasome activation and inflammation. However, the interaction between these responses and their role in driving pulmonary inflammation in stable COPD is unknown ...
Adcock, I, Balbi, B, Barczyk, A, Barnes, PJ, Brun, P, Cappello, F, Caramori, G, Casolari, P, Chung, KF, Contoli, M, Di Stefano, A, Durham, AL, Garofano, E, Padovani, A, Papi, A, Vicari, C, Zanini, A   +16 more
core   +1 more source

Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome

Blood, 2005
Hemophagocytic syndrome (HPS) is characterized by an uncontrolled and poorly understood activation of T-helper 1 (Th-1) lymphocytes and macrophages. We studied 20 patients with HPS secondary to infections, autoimmune disease, lymphoma, or cancer and observed that the concentrations of serum interleukin 18 (IL-18), a strong inducer of Th-1 responses ...
Karin, Mazodier, Valérie, Marin, Daniela, Novick, Catherine, Farnarier, Stéphane, Robitail, Nicolas, Schleinitz, Véronique, Veit, Pascale, Paul, Menachem, Rubinstein, Charles A, Dinarello, Jean-Robert, Harlé, Gilles, Kaplanski   +11 more
openaire   +3 more sources

A natural goldmine of binding proteins and soluble receptors simplified their translation to blockbuster drugs, all in one decade

Frontiers in Immunology, 2023
Human urinary proteins are a goldmine of natural proteins a feature that simplifies their translation to biologics. Combining this goldmine together with the ligand-affinity-chromatography (LAC) purification method, proved a winning formula in their ...
Daniela Novick
doaj   +1 more source

Interleukin-18 and interleukin-18 Binding Protein

Frontiers in Immunology, 2013
Interleukin-18 (IL 18) is a member of the IL 1 family of cytokines. Increasing reports have expanded the role of IL 18 in mediating inflammation in animal models of disease using IL 18 deficient mice, neutralization of IL 18 or deficiency in the IL 18 ...
Charles eDinarello, Charles eDinarello, Daniela eNovick, SooHun eKim, SooHun eKim, Gilles eKaplanski, Gilles eKaplanski   +6 more
doaj   +1 more source

Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms [PDF]

, 2017
Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age.
Bonini M, Canonica GW, DEL GIACCO, STEFANO, Gangemi S, Lombardi C, Minciullo PL, Paganelli R, Passalacqua G, Patella V, Ridolo E, Scichilone N, Simioni L, Ventura MT   +12 more
core   +1 more source

Weaning Failure in Critically Ill Patients Is Related to the Persistence of Sepsis Inflammation

Diagnostics, 2021
Introduction: Septic patients undergoing mechanical ventilation (MV) often experience difficulty in weaning. Th aim of this study was to determine whether inflammatory biomarkers of sepsis could be indicative of the failure or success of spontaneous ...
Anna Kyriakoudi, Nikoletta Rovina, Ourania Koltsida, Eirini Kostakou, Elissavet Konstantelou, Matina Kardara, Maria Kompoti, Anastasios Palamidas, Georgios Kaltsakas, Antonia Koutsoukou   +9 more
doaj   +1 more source

Waist-to-hip ratio and mortality in heart failure [PDF]

, 2018
Aims: A higher body mass index (BMI) is associated with better survival in heart failure (HF) patients, also known as the obesity paradox. However, BMI does not account for body composition.
Assarsson, Aune, Clark, Clark, Emdin, Ferreira, Han, Kaur, Komajda, Koster, Lavie, Lavie, Li, Manolopoulos, Nymo, Olivier, Ouwerkerk, Palmer, Parissis, Paulus, Perrone-Filardi, Piepoli, Pischon, Ponikowski, Ritchie, Rose, Russo, Santema, See, Selvaraj, Shah, Sharma, Tamariz, Tsujimoto, Voors, Voors, Weschenfelder   +36 more
core   +3 more sources

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis [PDF]

, 2022
Background and Aims: Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis. Mechanisms and downstream signaling remain incompletely understood.
Birmingham, Amanda, Boosheri, Laela M., Chilin‐Fuentes, Daisy R., Demir, Münevver, Feldstein, Ariel E., Fisch, Kathleen M., Geisler, Lukas, Hoffman, Hal M., Holtmann, Theresa Maria, Hundertmark, Jana, Inzaugarat, Maria Eugenia, Kaufmann, Benedikt, Knorr, Jana, Kohlhepp, Marlene Sophia, Loosen, Sven H., Roderburg, Christoph, Schilling, Joel D., Tacke, Frank, Trautwein, Christian, Wree, Alexander   +19 more
core   +1 more source

Altered Expression of Interleukin-18 System mRNA at the Level of Endometrial Myometrial Interface in Women with Adenomyosis

Current Issues in Molecular Biology, 2022
Adenomyosis is a uterine pathology characterized by a deep invasion of endometrial glands and stroma, disrupting the endometrial–myometrial interface (EMI).
Liang-Hsuan Chen, She-Hung Chan, Chin-Jung Li, Hsien-Ming Wu, Hong-Yuan Huang   +4 more
doaj   +1 more source