The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis [PDF]
Molecules, 2021 Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and ...
Samuel García-Arellano +5 more
doaj +2 more sources
Epithelial miR-206 targets CD39/extracellular ATP to upregulate airway IL-25 and TSLP in type 2-high asthma. [PDF]
JCI Insight, 2021 The epithelial cell–derived cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) initiate type 2 inflammation in allergic diseases, including asthma. However, the signaling pathway regulating these cytokines expression remains elusive.
Zhang K +11 more
europepmc +2 more sources
Role of IL-25 in Immunity [PDF]
Journal of Clinical and Diagnostic Research, 2015 IL-25 a 2o KDa protein mostly known as IL-17E, encoded by chromosome 14, and containing 117 amino acids. Cytokine IL-17 family consists of 6 members; IL-17A to IL-17F, among which IL-25 has a unique structure and function. The receptor of IL-25 (IL-17BR)
Azar Valizadeh +3 more
doaj +3 more sources
IL-25 (IL-17E) in epithelial immunology and pathophysiology
Journal of Allergy and Clinical Immunology, 2021 IL-25, also known as IL-17E, is a unique cytokine of the IL-17 family. Indeed, IL-25 exclusively was shown to strongly induce expression of the cytokines associated with type 2 immunity. Although produced by several types of immune cells, such as T cells, dendritic cells, or group 2 innate lymphoid cells, a vast amount of IL-25 derives from epithelial ...
Borowczyk, Julia +3 more
semanticscholar +5 more sources
CircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma. [PDF]
Drug Des Devel Ther, 2021 Background The development of drug resistance leads many NPC patients to experience disease relapse following the completion of chemotherapy. It is thus essential that the mechanistic basis for such chemoresistance be clarified in an effort to identify ...
Lin J +5 more
europepmc +2 more sources
Induction of IL-25 Expression in Human Nasal Polyp Epithelium by Influenza Virus Infection is Abated by Interferon-Alpha Pretreatment. [PDF]
J Inflamm Res, 2021 Background Epithelial cytokines including IL-25, IL-33 and thymic stromal lymphopoietin (TLSP) are recently established as drivers of type 2 chronic inflammatory diseases such as chronic rhinosinusitis with nasal polyps (CRSwNP).
Hong H +11 more
europepmc +2 more sources
Arthritis Research & Therapy, 2020 Background The present study aimed to evaluate the suppressive role of interleukin (IL)-25 in IL-22-induced osteoclastogenesis and receptor activator of nuclear factor κB ligand (RANKL) expression in rheumatoid arthritis (RA). Methods Serum from patients
Hong Ki Min +7 more
doaj +2 more sources
Evaluation of the Effects of 1,25VitD3 on Inflammatory Responses and IL-25 Expression [PDF]
Frontiers in Genetics, 2021 VitD3 may contribute to a successful pregnancy through modulation of immune responses, so VitD3 deficiency may have a role in the immunopathogenesis of unexplained recurrent spontaneous abortion (URSA). However, the mechanisms of immunomodulatory actions
Nana Li +10 more
doaj +2 more sources
Critical role of IL-25-ILC2-IL-5 axis in the production of anti-Francisella LPS IgM by B1 B cells. [PDF]
PLoS Pathog, 2021 B1 cells, a subset of B lymphocytes whose developmental origin, phenotype, and function differ from that of conventional B2 cells, are the main source of “natural” IgM but can also respond to infection by rapidly producing pathogen-specific IgM directed ...
Barbosa CHD +4 more
europepmc +2 more sources
TSLP, IL-33, and IL-25: Not just for allergy and helminth infection. [PDF]
J Allergy Clin Immunol, 2022 Stanbery AG +4 more
europepmc +2 more sources