Results 21 to 30 of about 1,106,140 (286)
IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline [PDF]
, 2016 Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment.
Chan, Ivy C. W. +10 more
core +1 more source
Serum IL-33 level and IL-33 gene polymorphisms in Behçet’s disease
Rheumatology International, 2014 Behçet's disease (BD) is a chronic inflammatory disease. Increased productions of cytokines including interleukin (IL)-1β and IL-18 are documented, and IL-1α and β gene polymorphisms are associated with susceptibility to the disease. IL-33 is a recently discovered member of IL-1 cytokine family.
Koca S.S. +6 more
openaire +2 more sources
IL-33/IL-31 Axis in Osteoporosis [PDF]
International Journal of Molecular Sciences, 2020 The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis is well known.
Massimo De Martinis +3 more
openaire +3 more sources
The association between airway eosinophilic inflammation and IL-33 in stable non-atopic COPD
Respiratory Research, 2018 Background Interleukin(IL)-33 is an epithelial alarmin important for eosinophil maturation, activation and survival. The aim of this study was to examine the association between IL-33, its receptor expression and airway eosinophilic inflammation in non ...
Damian Tworek +8 more
doaj +1 more source
IL-33/sST2 axis in The Cardiovascular System: A Brief Review [PDF]
Trends in Pharmaceutical Sciences, 2020 IL-33 is a type of cytokine and a new member of the IL-1 family labeled as an alarmin, which is released under stressful settings. IL-33 is a biomechanically induced protein and is mainly produced by cardiac fibroblasts and is expressed by various cell ...
Negar Firouzabadi, Maryam Dashti
doaj +1 more source
Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. [PDF]
, 2016 Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung.
Austen, K Frank +5 more
core +1 more source
Biotechnology & Biotechnological Equipment, 2018 IL-33 binding to IL1RL1 is involved in asthma. The data show that involvement of the IL33/IL1RL1 genes in asthma is biologically plausible. The objective of this study was to investigate the association of IL33 and IL1R1 gene polymorphisms and serum IL ...
Guangyang Zhang +4 more
doaj +1 more source
Structural Basis of IL-1 Family Cytokine Signaling
Frontiers in Immunology, 2019 Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli.
James K. Fields +6 more
doaj +1 more source
IL-33 Signaling in Lung Injury [PDF]
Translational Perioperative and Pain Medicine, 2016 Interleukin (IL)-33, a member of the IL-1 cytokine super-family, acts as both a traditional cytokine and an intracellular nuclear factor. It is generally released from damaged immune cells and signals through its receptor ST2 in an autocrine and paracrine fashion, plays important roles in type-2 innate immunity, and functions as an "alarmin" or a ...
Jing, Chang +3 more
openaire +2 more sources
Serum sST2 levels predict severe exacerbation of asthma
Respiratory Research, 2018 Background Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We hypothesized that high serum sST2 levels in stable asthmatics are a predictor for
Masato Watanabe +11 more
doaj +1 more source