The ST2/IL-33 Pathway in Adult and Paediatric Heart Disease and Transplantation
Biomedicines, 2023 ST2 is a member of interleukin 1 receptor family with soluble sST2 and transmembrane ST2L isoforms. The ligand of ST2 is IL-33, which determines the activation of numerous intracytoplasmic mediators following the binding with ST2L and IL-1RAcP, leading ...
Giacomina Brunetti +5 more
doaj +1 more source
Full length interleukin 33 aggravates radiation-induced skin reaction [PDF]
, 2017 The interleukin (IL)-1 family member IL-33 has been described as intracellular alarmin with broad roles in wound healing, skin inflammation but also autoimmunity.
Adam, Susanne +13 more
core +3 more sources
Journal of Asthma and Allergy, 2021 Li Y Drake,1,2 Kathleen R Bartemes,1,3 Kay A Bachman,1 John B Hagan,1 Hirohito Kita1,4 1Division of Allergic Diseases and Department of Medicine, Mayo Clinic, Rochester, MN, USA; 2Department of Anesthesiology and Perioperative Medicine, Mayo Clinic ...
Drake LY +4 more
doaj
Interleukin-33 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways [PDF]
, 2015 Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer, it remains a huge challenge to understand the cellular and molecular mechanisms of the aggressive behavior of EOC cells.
Armstrong +51 more
core +1 more source
IL-33 Exacerbates Autoantibody-Induced Arthritis [PDF]
The Journal of Immunology, 2010 Abstract Rheumatoid arthritis pathogenesis comprises dysregulation in both innate and adaptive immunity. There is therefore intense interest in the factors that integrate these immunologic pathways in rheumatoid arthritis. In this paper, we report that IL-33, a novel member of the IL-1 family, can exacerbate anti–glucose-6-phosphate ...
Xu, Damo +11 more
openaire +3 more sources
Endogenous IL-33 and Its Autoamplification of IL-33/ST2 Pathway Play an Important Role in Asthma. [PDF]
, 2020 IL-33 and its receptor ST2 are contributing factors to airway inflammation and asthma exacerbation. The IL-33/ST2 signaling pathway is involved in both the onset and the acute exacerbations of asthma.
Dumouchel, Justin P +5 more
core
Wounds that heal and wounds that don't - The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis [PDF]
, 2016 IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation.
Brint, Elizabeth K. +3 more
core +1 more source
Effects of IL-33 on HaCAT cell line and psoriasis-like lesion in mouse model [PDF]
Jichu yixue yu linchuang, 2020 Objective To investigate the effects of interleukin-33(IL-33)on HaCAT cells and psoriasis-like inflammation induced by imiquimod(IMQ) in mice. Methods Twenty-four hours after HaCAT cells were plated, the cell proliferation and autophagy-related protein ...
DUAN Ya-ju, WANG Wen-qian, HU Hua, FU Dan-dan, SONG Xiang-feng, TIAN Zhong-wei
doaj
Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors
Frontiers in Immunology, 2020 Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado +15 more
doaj +1 more source
Different members of the IL-1 family come out in different ways: DAMPs vs cytokines?
Frontiers in Immunology, 2013 Intercellular communications control fundamental biological processes required for the survival of multicellular organisms. Secretory proteins are among the most important messengers in this network of information.
Sonia eCarta +2 more
doaj +1 more source