Results 61 to 70 of about 1,087,614 (283)

Lung epithelium is the major source of IL-33 and is regulated by IL-33-dependent and IL-33-independent mechanisms in pulmonary cryptococcosis [PDF]

Pathogens and Disease, 2016
Inhalation of the fungus Cryptococcus neoformans (C. neoformans) results in pulmonary cryptococcosis associated with IL-33-dependent type 2 immunity. Lung epithelium represents the initial contact site of infection. The role of IL-33 in type 2 immunity has been analyzed, but the source of this cytokine and its effect on lung epithelial cell function in
Laura, Heyen, Uwe, Müller, Sabine, Siegemund, Bianca, Schulze, Martina, Protschka, Gottfried, Alber, Daniel, Piehler   +6 more
openaire   +2 more sources

Potential Early Risk Biomarkers for Reduced Forced Expiratory Volume in Children Post‐Hematopoietic Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small, Pi Chun Cheng, April L. Rahrig, Courtney M. Rowan   +3 more
wiley   +1 more source

Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor

Frontiers in Immunology, 2021
Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of stimuli. Aberrant signaling by IL-1 family cytokine members, however, is linked to myriad inflammatory
James K. Fields, James K. Fields, James K. Fields, Kyle Kihn, Gabriel S. Birkedal, Erik H. Klontz, Erik H. Klontz, Erik H. Klontz, Kjell Sjöström, Sebastian Günther, Robert Beadenkopf, Göran Forsberg, David Liberg, Greg A. Snyder, Greg A. Snyder, Daniel Deredge, Eric J. Sundberg   +16 more
doaj   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis

Molecules, 2021
Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and ...
Samuel García-Arellano, Luis Alexis Hernández-Palma, Sergio Cerpa-Cruz, Gabriela Athziri Sánchez-Zuno, Melva Guadalupe Herrera-Godina, José Francisco Muñoz-Valle   +5 more
doaj   +1 more source

Serum IL-33, a new marker predicting response to rituximab in rheumatoid arthritis [PDF]

, 2016
Background. Recent works have suggested a possible link between IL-33 and B-cell biology. We aimed to study in different cohorts and with an accurate ELISA assay the possible association between serum IL-33 detection and response to rituximab (RTX) in ...
A Ahmed, Alice Courties, AM Gestel van, B Stolarski, Barbara Tolusso, Bineta Ly, D Talabot-Ayer, D Xu, D Xu, E Kunisch, E Rivière, E-J Lee, Edward M. Vital, Elodie Rivière, F Rivellese, FY Liew, Gianfranco Ferraccioli, Houria Hendel Chavez, J Malcolm, J Schmitz, J Sellam, J Sellam, J Sellam, J Shen, Jérémie Sellam, M Broek van den, M Couderc, M Komai-Koma, Martin Soubrier, Maxime Dougados, NL Millar, P Martin, Paul Emery, Paul-Olivier Rouzaire, S Sattler, SK Athari, TC Theoharides, X Mariette, Xavier Mariette, Yassine Taoufik, Z Xiangyang   +40 more
core   +6 more sources

IL-33: a Janus cytokine

Annals of the Rheumatic Diseases, 2012
Interleukin (IL) 33, a member of the IL-1 family, is the ligand of ST2 that is expressed mainly on activated Th2 cells and mast cells. IL-33 can skew a predominantly Th1 cell population to a mainly Th2 cells phenotype in vivo. IL-33 messenger RNA is expressed early during infection of the intestinal-dwelling nematode Trichuris muris in mice.
openaire   +2 more sources

IL-33 and kidney disease (Review)

Molecular Medicine Reports, 2015
Interleukin (IL)-33, is a novel member of the IL-1 superfamily, and act as a dual-function molecule as a nuclear factor and cytokine. The expression of IL-33 can be detected in several tissues and cells in humans and in mice. In addition to the conventional secretion approach for cytokines, full-length IL-33 can also be released into the extracellular ...
Feifei, Yang, Ping, Zhu, Lihua, Duan, Lin, Yang, Jiajun, Wang   +4 more
openaire   +3 more sources

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

IL-31 and IL-33 in rheumatoid arthritis patients

Научно-практическая ревматология, 2022
Objective – to investigate clinical and diagnostic significance of IL-31 and IL-33 determination in patients with rheumatoid arthritis (RA).Material and methods. 154 patients with a reliable diagnosis of RA were examined.
N. A. Lapkina, A. A. Baranov, N. E. Abaytova, N. Yu. Levshin, O. P. Rechkina, E. A. Leontyeva, A. S. Avdeyeva, A. S. Artyukhov, E. L. Nasonov   +8 more
doaj   +1 more source