Results 11 to 20 of about 3,328 (148)

Delivery of IL-35 by Lactococcus lactis Ameliorates Collagen-Induced Arthritis in Mice

Frontiers in Immunology, 2018
IL-35, a relatively newly discovered cytokine belonging to the larger IL-12 family, shows unique anti-inflammatory properties, believed to be associated with dedicated receptors and signaling pathways.
Massimo Maddaloni, Irina Kochetkova, Carol Hoffman, David W. Pascual   +3 more
doaj   +1 more source

IL10- and IL35-Secreting MutuDC Lines Act in Cooperation to Inhibit Memory T Cell Activation Through LAG-3 Expression

Frontiers in Immunology, 2021
Dendritic cells (DCs) are professional antigen-presenting cells involved in the initiation of immune responses. We generated a tolerogenic DC (tolDC) line that constitutively secretes interleukin-10 (IL10-DCs), expressed lower levels of co-stimulatory ...
Marianna M. Koga, Adrien Engel, Matteo Pigni, Christine Lavanchy, Mathias Stevanin, Vanessa Laversenne, Bernard L. Schneider, Bernard L. Schneider, Hans Acha-Orbea   +8 more
doaj   +1 more source

Interleukin-35 Expression in Non-Small Cell Lung Cancer is Associated with Tumor Progression

Cellular Physiology and Biochemistry, 2018
Background/Aims: Lung cancer continues to be the leading cause of cancer related deaths worldwide due to its high incidence, malignant behavior and lack of major advancements in treatment strategy. The occurrence and development of lung cancer is closely
Mingfei Sun, Xianjie Zheng, Qingjiang Meng, Yanjun Dong, Guoyu Zhang, Dexin Rao, Xiaokang An, Zhongxin Yang, Lihong Pan, Shuanglin Zhang   +9 more
doaj   +1 more source

Serum IL-35 Levels Are Associated With Activity and Progression of Sarcoidosis

Frontiers in Immunology, 2020
Objective: To investigate the relationship of interleukin (IL)-35 with sarcoidosis.Methods: We enrolled 114 inpatients and outpatients with sarcoidosis at the Shanghai Pulmonary Hospital, and 24 healthy controls between March 2015 and December 2017 ...
Zhao Mengmeng, Song Jiacui, Song Jiacui, Du Shanshan, Zhang Yuan, Zhou Ying, Li Qiuhong, Weng Dong, Li Hui-Ping   +8 more
doaj   +1 more source

Effect of Epigallocatechin gallate (EGCG) on Production of Dendritic Cells from Peripheral Blood Monocytes

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: Dendritic cells are professional antigen presenting cells that initiate and modulate immune responses. Epigallocatechin gallate (EGCG) is identified as a prophylactic agent that can suppress tumor formation. This research aimed at
Mohammad Ali Mofid Nakhaei, Nabiallah Mohammadi, Saeid Abediankenari   +2 more
doaj  

The role of IL-35 and IL-37 in breast cancer – potential therapeutic targets for precision medicine

Frontiers in Oncology, 2022
Breast cancer is still a major concern due to its relatively poor prognosis in women, although there are many approaches being developed for the management of breast cancer.
Yuntao Ma, He Su, Xuyun Wang, Xiangdong Niu, Yang Che, Brett D. Hambly, Shisan Bao, Xiaopeng Wang   +7 more
doaj   +1 more source

IL-35 and IL-10 Role in The Immune Response of Colorectal Cancer in Iraqi Patients

مجلة الكوفة الطبية
Background: Colorectal cancer (CRC) is presented in the colon and rectum (large intestine) and the disease is expanding worldwide, CRC ranks as the third most common cancer worldwide and cervical cancer is the fourth most common locally.
Saja J. Muhammed, Ahmed Rushdi Abdullah, Nawar Sahib Khalil   +2 more
doaj   +1 more source

Expression and clinical significance of serum TRAIL-R2 and IL-35 in placenta accreta spectrum disorders [PDF]

Yixue xinzhi zazhi
Objective To investigate the expression and clinical significance of serum tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) and interleukin-35 (IL-35) in placenta accreta spectrum (PAS).Methods Retrospectively select PAS ...
LI Meiyi, HU Ke, LI Wenxia, LI Hua, ZHAO Lijing, SHI Jun   +5 more
doaj   +1 more source

Shifting the paradigm in bipolar disorder: moving beyond conventional inflammatory markers to novel EBI3-containing heterodimeric cytokines

Frontiers in Psychiatry
BackgroundResearch shows immune dysregulation in bipolar disorder (BD), but clinical heterogeneity and variable treatment responses persist around inflammatory markers like IL-6, TNF-α, and CRP.
Junfang Wu, Meixia Li, Long Cheng, Jun Chai, Shanshan Zhai   +4 more
doaj   +1 more source

Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis

Endocrine Regulations, 2016
Objective. Interleukin-35 (IL-35), an interleukin-12 (IL-12) cytokine family member, is shown to be a potent immunosuppressive and anti-inflammatory cytokine. Inducible regulatory T cells (Tregs) produce IL-35 that mediates the immune inhibitory function
Yilmaz Hakki, Cakmak M., Ceydilek B., Demir C., Aktas A.   +4 more
doaj   +1 more source