IL-17A-driven psoriasis is critically dependent on IL-36 signaling [PDF]
Frontiers in Immunology, 2023 Plaque psoriasis is an autoinflammatory and autoimmune skin disease, affecting 1-3% of the population worldwide. Previously, high levels of IL-36 family cytokines were found in psoriatic skin lesions, thereby contributing to keratinocyte ...
Berenice Fischer +13 more
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The role of IL-36 and 37 in hepatocellular carcinoma [PDF]
Frontiers in ImmunologyHepatocellular carcinoma (HCC) has garnered considerable attention due to its morbidity and mortality. Although the precise mechanisms underlying HCC tumorigenesis remain to be elucidated, evidence suggests that host immunity plays a pivotal role in its ...
Juan Cao +7 more
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IL-36-related genes predict prognosis of gastric cancer [PDF]
Frontiers in OncologyIntroductionGastric cancer (GC) is one of the most frequently encountered malignant tumors in the clinic. Because effective early screening techniques are lacking, most patients have advanced disease at first diagnosis.
Ying Zhang +9 more
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IL-36 is Closely Related to Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease [PDF]
International Journal of COPD, 2022 Siyuan Huang,1,* Tao Feng,2,* Jing Wang,1 Liang Dong3 1Department of Respiratory, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Respiratory Medicine, Shengli ...
Huang S, Feng T, Wang J, Dong L
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Dichotomous roles of IL-36 and IL-38 in cardiovascular disease [PDF]
Frontiers in ImmunologyMembers of the interleukin-1 (IL-1) superfamily play crucial roles in orchestrating inflammation and immune responses. Among them, IL-36 and IL-38 have emerged as cytokines with contrasting roles in cardiovascular disease (CVD).
Haifeng Zhang, Wenhui Huang, Shisan Bao
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The Role of IL-36 in Infectious Diseases: Potential Target for COVID-19? [PDF]
Frontiers in Immunology, 2021 IL-36 is a member of the interleukin 1 cytokine family, which is currently experiencing a renaissance due to the growing understanding of its context-dependent roles and advances in our understanding of the inflammatory response.
Xiaofang Wang +4 more
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IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic [PDF]
Frontiers in Immunology, 2022 Interleukin (IL)-36 cytokines are members of the IL-1 superfamily, which consists of three agonists (IL-36α, IL-36β and IL-36γ) and an IL-36 receptor antagonist (IL-36Ra). IL-36 cytokines are crucial for immune and inflammatory responses. Abnormal levels
Hongna Dong +4 more
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IL-36 participated in airway remodeling in chronic asthma model by inducing epithelial–mesenchymal transition process [PDF]
European Journal of Medical ResearchPurpose Epithelial–mesenchymal transition (EMT) is a major pathological characteristic of airway remodelling in severe asthma. Interleukin (IL)-36 belongs to the IL-1 family and is associated with allergic disease, but the role of IL-36 in airway ...
Min Zhang +7 more
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IL-1α and IL-36 Family Cytokines Can Undergo Processing and Activation by Diverse Allergen-Associated Proteases [PDF]
Frontiers in Immunology, 2022 Inflammation driven by environmental allergens is an important source of morbidity in diseases such as asthma and eczema. How common allergens promote inflammation is still poorly understood, but previous studies have implicated the protease activity ...
Valentina Frezza +4 more
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Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review [PDF]
Journal of Inflammation ResearchYuan Xu, Jing-Yan Wang, Yang Zou, Xue-Wei Ma, Tian Meng College of Health Industry, Sichuan Tourism University, Chengdu, Sichuan, 610100, People’s Republic of ChinaCorrespondence: Yuan Xu, Email 230973159@qq.comAbstract: Inflammatory cytokines ...
Xu Y, Wang JY, Zou Y, Ma XW, Meng T
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