Results 11 to 20 of about 1,034,039 (274)

Influence of serum IL-36 subfamily cytokines on clinical manifestations of asthma [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: The IL-36 subfamily, a member of the IL-1 superfamily, is thought to promote type 2 (T2) and non-T2 inflammation and involved in autoimmune and airway disease progression. However, its role in asthma remains unclear.
Yuki Hoshino, MD, Tomoyuki Soma, MD, PhD, Kazuyuki Nakagome, MD, PhD, Reina Ishii, MD, Tatsuhiko Uno, MD, Kazuki Katayama, MD, Hidetoshi Iemura, MD, Erika Naitou, MD, Takahiro Uchida, MD, PhD, Yoshitaka Uchida, MD, PhD, Hidetoshi Nakamura, MD, PhD, Makoto Nagata, MD, PhD   +11 more
doaj   +2 more sources

Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines

Cell Reports, 2016
Recent evidence has strongly implicated the IL-1 family cytokines IL-36α, IL-36β, and IL-36γ as key initiators of skin inflammation. Similar to the other members of the IL-1 family, IL-36 cytokines are expressed as inactive precursors and require ...
Conor M. Henry, Graeme P. Sullivan, Danielle M. Clancy, Inna S. Afonina, Dagmar Kulms, Seamus J. Martin   +5 more
doaj   +5 more sources

IL‐36 cytokines and gut immunity [PDF]

Immunology, 2021
SummaryInterleukin 36 (IL‐36) constitutes a group of cytokines that belong to the IL‐1 superfamily. Emerging evidence has suggested a role of IL‐36 in the pathogenesis of many inflammatory disorders. Intriguingly, in the gastrointestinal tract, IL‐36 has a rather complex function.
Vu L. Ngo, Michal Kuczma, Estera Maxim, Timothy L. Denning   +3 more
openaire   +2 more sources

IL-36 Signaling in the Tumor Microenvironment. [PDF]

Adv Exp Med Biol, 2020
The ability of the immune system to prevent or control the growth of tumor cells is critically dependent on inflammatory processes that lead to the activation, expansion, and recruitment of antitumor effector cells into the tumor microenvironment (TME).
Chelvanambi M, Weinstein AM, Storkus WJ.
europepmc   +4 more sources

IL-36 in chronic inflammation and fibrosis - bridging the gap? [PDF]

J Clin Invest, 2021
IL-36 is a member of the IL-1 superfamily and consists of three agonists and one receptor antagonist (IL-36Ra). The three endogenous agonists, IL-36α, -β, and -γ, act primarily as proinflammatory cytokines, and their signaling through the IL-36 receptor (IL-36R) promotes immune cell infiltration and secretion of inflammatory and chemotactic molecules ...
Elias M, Zhao S, Le HT, Wang J, Neurath MF, Neufert C, Fiocchi C, Rieder F.   +7 more
europepmc   +4 more sources

The new external drug for the treatment of psoriasis based on inhibition of serine proteases

Vestnik Dermatologii i Venerologii, 2021
Background: Psoriasis is a chronic inflammatory immune-mediated disease characterized by an increased rate of keratinocyte division. The results of recent studies have made it possible to establish that the cytokines of the IL-36 family occupy a ...
Alexander S. Zhukov, Evgeny R. Zharun, Vladislav R. Khairutdinov, Alexey V. Samtsov, Mihail Yu. Krasavin, A. V. Garabagiou   +5 more
doaj   +1 more source

IkBζ is a Key Regulator of Tumour Necrosis Factor-a and Interleukin-17A-mediated Induction of Interleukin-36g in Human Keratinocytes

Acta Dermato-Venereologica, 2021
The interleukin (IL)-36 cytokine family plays an essential role in inflammatory processes in the skin and is implicated in the pathogenesis of psoriasis. This study explored the role of IL-36 in psoriasis and investigated the molecular mechanism involved
Sofie Kaas Ovesen, Klaus Schulze-Osthoff, Lars Iversen, Claus Johansen   +3 more
doaj   +1 more source

Infiltrative-Suppurative Form of Scalp Microsporia in a Child with Generalized Pustular Psoriasis of von Zumbusch: Clinical Case

Вопросы современной педиатрии, 2021
Background. This article discusses issues of diagnosis and management of pustular psoriasis in a child associated with recurrent dermatomycosis, immunopathogenetic mechanisms of pustular psoriasis, its course and prognosis. Clinical Case Description. The
Andrey L. Bakulev, Sergey S. Kravchenya, Irina A. Igonina   +2 more
doaj   +1 more source

Effect of YangxueJiedu Decoction on the expression levels of IL-36 in psoriasis-like lesions in mice

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective: To explore the effect of YangxueJiedu decoction on IL-36 expression in a mouse model of imiquimod-induced psoriasis-like lesions. Methods: Eighteen mice were randomly divided into the control, model and experimental groups, with 6 mice per ...
Qi ZHANG, Lei ZHU, Yuqi HUANG, Yongfeng CHEN   +3 more
doaj   +1 more source

IL-36 cytokines imprint a colitogenic phenotype on CD4⁺ T helper cells. [PDF]

Mucosal Immunol, 2022
IL-36 cytokines are emerging as potent orchestrators of intestinal inflammation and are being implicated in the pathogenesis of inflammatory bowel diseases (IBD). However, the mechanisms through which these cytokines mediate these effects remain to be fully uncovered.
Leon G, Hernandez Santana YE, Irwin N, Giannoudaki E, O'Neill S, Csizmadia I, Gogarty M, Lee TJ, Ruane D, Long A, Fallon PG, Hussey S, Walsh PT.   +12 more
europepmc   +4 more sources