Results 21 to 30 of about 1,034,039 (274)

Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes [PDF]

, 2020
Non-healing chronic ulcers are a serious complication of diabetes and are a major healthcare problem. While a host of treatments have been explored to heal or prevent these ulcers from forming, these treatments have not been found to be consistently ...
A Avogaro, A Gaultier, A Le Guelte, A Magli, AA Anderson, AE Rodríguez-Fraticelli, AJ Monteforte, B Shu, BG Seligman, C Ling, C Margadant, C Ozbayer, C Shi, C Tian, C Ung, C Vanderplanck, C Wu, D Bosnakovski, D Bosnakovski, D Karthik, D Lazzaro, DJ Mangelsdorf, DM D'Souza, DS Frankel, E Ansseau, E Ansseau, E Nilsson, EA Coon, EA Malt, EM Small, F Gragnano, F Guan, G Theocharidis, G. Said, GH Wong, GJ Berry, GJ Berry, GL Bellot, GV Gnoni, H Andersen, H Brem, HA Ramirez, I Bettahi, I Bettahi, I Chakroun, I Gottfried, IN Vial, J Thimmarayappa, J Xu, J Yan, JB Rice, JC Corton, JG Van Vranken, JS Hansen, K Blackburn, KM Popov, L Nasarre, L Tan, LA Berchtold, LE Reynolds, M Gupta, M Wight, MA Faghihi, MK Montgomery, MR Tanner, MR Tanner, N Schonrock, N Takagi, NY Yoshihito Nogusa, P Hebbar, P Rajendran, PJ Batista, PM Mannucci, RB Tajhya, RC Pink, RN Weijers, RS Kaplan, RS Kiss, S Baldari, S Barrientos, S Das, S Das, S Lambert, S Rovira-Llopis, S Roy, S Sethumadhavan, SM Weis, SS Kulkarni, SV Suryavanshi, SY Park, T Fujiwara, T Khalfaoui, T Thiruvoipati, T Wang, T-H Wang, TT Hien, V Iacobazzi, V Miragliotta, VV Sinyov, W Meng, WI Sivitz, WM Longmate, WM Longmate, X Shi, X Wang, X Xie, X Yuan, X Zhao, X Zhao, Y Cai, Y Carrier, Y Chen, Y Gu, Y Konishi, Y Liu, Y Wang, Y-T Chen, Y-Y Hsieh, Z Jiang, Z-X Meng, ZKK Lawi   +120 more
core   +1 more source

IL-36 expression is increased in NSCLC with IL-36 stimulation of lung cancer cells promoting a pro-tumorigenic phenotype

Cytokine, 2023
The IL-36 cytokines are a recently described subset of the IL-1 family of cytokines, and have been shown to play a role in the pathogenesis of respiratory diseases such as asthma and COPD. Given the common aetiological links between COPD and lung cancer development, as well as the involvement of other IL-1 family members in lung tumorigenesis, the aim ...
Kevin James, Baker, Emily, Buskiewicz, Méabh, Finucane, Adeleine, Chelliah, Louise, Burke, Aileen, Houston, Elizabeth, Brint   +6 more
openaire   +2 more sources

IL-36γ has proinflammatory effects on human endothelial cells [PDF]

, 2016
Interleukin-36 cytokines are predominantly expressed by epithelial cells. Significant upregulation of epidermal IL-36 is now a recognised characteristic of psoriatic skin inflammation.
Alase, Adewonuola, Bridgewood, Charlie, Graham, Anne, Lagos, Dimitris, Stacey, Martin, Wittmann, Miriam   +5 more
core   +2 more sources

Rationale for IL-36 receptor antibodies in ulcerative colitis [PDF]

Expert Opinion on Biological Therapy, 2019
Ulcerative colitis (UC) is a chronically relapsing inflammatory disease of the colonic mucosa. It affects genetically susceptible hosts that are influenced by environmental factors and contribution...
Clemens, Neufert, Markus F, Neurath, Raja, Atreya   +2 more
openaire   +2 more sources

Structural Basis of IL-1 Family Cytokine Signaling

Frontiers in Immunology, 2019
Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli.
James K. Fields, James K. Fields, James K. Fields, Sebastian Günther, Eric J. Sundberg, Eric J. Sundberg, Eric J. Sundberg   +6 more
doaj   +1 more source

IL-36α Exerts Pro-Inflammatory Effects in the Lungs of Mice [PDF]

, 2012
Interleukin (IL-) 36 cytokines (previously designated as novel IL-1 family member cytokines; IL-1F5– IL-1F10) constitute a novel cluster of cytokines structurally and functionally similar to members of the IL-1 cytokine cluster.
Ewart, Susan L., Iwakura, Yoichiro, LeVine, Ann Marie, Medoff, Benjamin D., Ramadas, Ravisankar A.   +4 more
core   +3 more sources

Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus Erythematosus [PDF]

, 2015
published_or_final_versio
Cai, Z, Chu, M, Dong, J, Jiao, D, Kam, NW, Lam, C, Tam, L, Wong, C   +7 more
core   +2 more sources

Limited Contribution of IL-36 versus IL-1 and TNF Pathways in Host Response to Mycobacterial Infection [PDF]

, 2015
IL-36 cytokines are members of the IL-1 family of cytokines that stimulate dendritic cells and T cells leading to enhanced T helper 1 responses in vitro and in vivo ; however, their role in host defense has not been fully addressed thus far.
Segueni, Noria, Vigne, Solenne, Palmer, Gaby, Bourigault, Marie-Laure, Olleros, Maria L., Vesin, Dominique, Garcia, Irene, Ryffel, Bernhard, Quesniaux, Valérie F. J., Gabay, Cem   +9 more
core   +1 more source

Interleukin(IL)-36α and IL-36γ Induce Proinflammatory Mediators from Human Colonic Subepithelial Myofibroblasts [PDF]

, 2015
Background: Interleukin (IL)-36 cytokines are recently reported member of the IL-1 cytokine family. However, there is little information regarding the association between IL-36 cytokines and gut inflammation.
Akira Andoh, Atsushi Nishida, Hirotsugu Imaeda, Kenichiro Takahashi, Kentaro Hidaka, Mitsushige Sugimoto, Osamu Inatomi, Shigeki Bamba, Toshihiro Kanda   +8 more
core   +3 more sources

Glucose Homeostasis in Relation to Neutrophil Mobilization in Smokers with COPD

International Journal of COPD, 2022
Nikolaos Pournaras,1,2 Anders Andersson,3,4 Melissa A Kovach,1 Médea Padra,5 Karlhans F Che,1,2 Bettina Brundin,1 Shigemi Yoshihara,6 Steven Bozinovski,7 Sara K Lindén,5 Per-Anders Jansson,8 Magnus C Sköld,2,9 Ingemar Qvarfordt,3,8 Anders Lindén1,2 ...
Pournaras N, Andersson A, Kovach MA, Padra M, Che KF, Brundin B, Yoshihara S, Bozinovski S, Lindén SK, Jansson PA, Sköld MC, Qvarfordt I, Lindén A   +12 more
doaj