Results 31 to 40 of about 1,034,039 (274)
Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection [PDF]
, 2017 Tick-borne encephalitis virus (TBEV) is a member of the genus Flavivirus. It can cause serious infections in humans that may result in encephalitis/meningoencephalitis. Although several studies have described the involvement of specific genes in the host
Grubhoffer, Libor +6 more
core +2 more sources
IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist [PDF]
Proceedings of the National Academy of Sciences, 2012 The functional role of IL-1 family member 10, recently renamed IL-38, remains unknown. In the present study we aimed to elucidate the biological function of IL-38 and to identify its receptor. Heat-killed Candida albicans was used to stimulate memory T-lymphocyte cytokine production in freshly obtained human ...
Veerdonk, F.L. van de +10 more
openaire +4 more sources
An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target [PDF]
Science Translational Medicine, 2017 IL-36 receptor (IL-36R) blockade ameliorates psoriatic inflammation and should be well tolerated, because IL-36R knockout mutations are benign.
Satveer K. Mahil +12 more
openaire +4 more sources
Clinical, Cosmetic and Investigational Dermatology, 2023 Jason E Hawkes,1,* Dale V Reisner,2 Tina Bhutani3,* 1Department of Dermatology, University of California at Davis, Sacramento, CA, USA; 2Patient Author, Yankton, SD, USA; 3Psoriasis and Skin Treatment Center, Department of Dermatology, University
Hawkes JE, Reisner DV, Bhutani T
doaj
Cell Reports, 2020 Summary: Epithelial tissues represent vital interfaces between organisms and their environment. As they are constantly exposed to harmful pathogens, innocuous commensals, and environmental microbes, it is essential they sense and elicit appropriate ...
Thomas Macleod +11 more
doaj +1 more source
The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier
Frontiers in Immunology, 2021 The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked.
Tom Macleod +8 more
doaj +1 more source
IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis
Frontiers in Immunology, 2019 The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals.
Erin Fahey +4 more
doaj +1 more source
Frontiers in Immunology, 2023 Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disorder characterized by recurrent flares associated with skin erythema, desquamation, and widespread superficial sterile pustules, which may be severe (“lakes of pus”). Systemic
Jason E. Hawkes +2 more
doaj +1 more source
IL-36 cytokines in autoimmunity and inflammatory disease
Oncotarget, 2017 The inteleukin-36 (IL-36) cytokines include IL-36α, IL-36β, IL-36γ and IL-36Ra, which belong to the IL-1 family and exert pro-inflammatory effects on various target cells such as keratinocytes, synoviocytes, dendritic cells and T cells. Emerging evidence has suggested a role of IL-36 in the pathogenesis of many inflammatory diseases. Here, we provide a
Ding, Liping +4 more
openaire +3 more sources
Consideration of serum IL‐36α and β levels trends in two patients with chikungunya fever
Clinical Case Reports, 2023 Key Clinical Message IL‐36 might play a role as an initial immune mechanism against chikungunya fever, and regulating IL‐36 production could be a potential treatment approach for this condition. Abstract Two Japanese siblings visited Cook Islands in 2015
Makoto Kondo +5 more
doaj +1 more source