Results 1 to 10 of about 15,271,445 (192)
IL-4 Is a Key Requirement for IL-4- and IL-4/IL-13-Expressing CD4 Th2 Subsets in Lung and Skin
Frontiers in Immunology, 2018 Although IL-4 is long associated with CD4 Th2 immune responses, its role in Th2 subset development in non-lymphoid tissues is less clear. We sought to better define IL-4’s role in CD4 Th2 responses by using transgenic mice that express a dual IL-4 AmCyan/
Melanie Sarah Prout +3 more
doaj +2 more sources
Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets
Frontiers in Pharmacology, 2022 Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking.
Corrado Pelaia +8 more
doaj +1 more source
IL-4 and IL-13: Regulators and Effectors of Wound Repair.
Annual Review of Immunology, 2022 Type 2 immunity mediates protective responses to helminths and pathological responses to allergens, but it also has broad roles in the maintenance of tissue integrity, including wound repair. Type 2 cytokines are known to promote fibrosis, an overzealous
J. Allen
semanticscholar +1 more source
Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
Cells, 2021 Interleukin (IL)-4 and IL-13 belong to the T helper 2 (Th2) cytokine family, along with IL-3, IL-5, and IL-9. These cytokines are key mediators of allergic inflammation.
M. Iwaszko +2 more
semanticscholar +1 more source
Associations between Interleukin-4 and COVID-19 severity: A systematic review and meta-analysis [PDF]
Journal of Health and Social Sciences, 2022 Introduction: This systematic review and meta-analysis aimed to determine the correlation between IL-4 concentrations and COVID-19 severity. Methods: This study was designed as a systematic review and meta-analysis and was performed in accordance to ...
Michal MATUSZEWSKI +10 more
doaj +1 more source
Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: Its implications in cancer immunotherapy
SAGE Open Medicine, 2022 Cytokines play a critical role in regulating host immune response toward cancer and determining the overall fate of tumorigenesis. The tumor microenvironment is dominated mainly by immune-suppressive cytokines that control effector antitumor immunity and
B. Mirlekar
semanticscholar +1 more source
Recent advances in understanding the role of IL-4 signaling
Faculty Reviews, 2021 Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this cytokine acts on more than a dozen different target cells ...
A. Keegan, W. Leonard, Jinfang Zhu
semanticscholar +1 more source
IL-4 Exacerbates Anaphylaxis [PDF]
The Journal of Immunology, 2003 Abstract We evaluated whether IL-4, a cytokine critical for inducing allergic responses, also contributes to the effector phase of allergy. Pretreatment of mice with IL-4 or the related cytokine, IL-13, rapidly and dramatically increased the severity of anaphylaxis induced by cross-linking FcεRI or FcγRIII.
Richard T, Strait +4 more
openaire +2 more sources
Saliva as Alternative Specimen for Measuring Inflammatory Markers Interleukins (IL10, IL-4, and IL-1β) in Association with Disease Severity among COVID-19 Patients [PDF]
International Journal of Biomedicine, 2023 Background: Saliva is a specimen that is easily collected by non-invasive means and does not require well-trained staff; it could be helpful in measuring inflammatory markers to determine COVID-19 severity. The aim of this study was to investigate saliva
Samia M. Ahmed +6 more
doaj +1 more source
International Journal of Molecular Sciences, 2020 Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier dysfunction and elevated interleukin (IL)-4 and IL-13 signatures.
M. Furue
semanticscholar +1 more source