Results 31 to 40 of about 1,990,850 (192)

Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice. [PDF]

, 2014
Antigen-based therapies (ABTs) fail to restore normoglycemia in newly diabetic NOD mice, perhaps because too few β-cells remain by the time that ABT-induced regulatory responses arise and spread.
Chen, Zheying, Dang, Hoa, Kaufman, Daniel L, Nguyen, An Viet, Tian, Jide   +4 more
core   +1 more source

Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells

Virulence, 2019
Citrobacter rodentium infection is a murine model for pathogenic intestinal Escherichia coli infection. C. rodentium infection causes an initial decrease in mucus layer thickness, followed by an increase during clearance.
S. Sharba, N. Navabi, M. Padra, J. A. Persson, M. P. Quintana-Hayashi, J. K. Gustafsson, L. Szeponik, V. Venkatakrishnan, Å. Sjöling, S. Nilsson, M. Quiding-Järbrink, M. E. V. Johansson, S. K. Linden   +12 more
doaj   +1 more source

Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors

Frontiers in Immunology, 2020
Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado, Aurora Holgado, Harald Braun, Harald Braun, Kenneth Verstraete, Kenneth Verstraete, Domien Vanneste, Domien Vanneste, Nico Callewaert, Nico Callewaert, Savvas N. Savvides, Savvas N. Savvides, Inna S. Afonina, Inna S. Afonina, Rudi Beyaert, Rudi Beyaert   +15 more
doaj   +1 more source

Pathogenesis of Atopic Dermatitis: Current Paradigm [PDF]

Iranian Journal of Immunology, 2019
Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized.
Masutaka Furue, Dugarmaa Ulzii, Yen Vu, Gaku Tsuji, Makiko Kido-Nakahara, Takeshi Nakahara   +5 more
doaj   +1 more source

Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity

Monaldi Archives for Chest Disease
Asthma is a heterogeneous disease characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and intensity, together with ...
Nidhi Girdhar, Karan Sharma, Satyajit Deshpande, Siddharth Sharma, Vishal Chopra, Anil Sontakke   +5 more
doaj   +1 more source

IL4-589C>T GENE POLYMORPHISM AND EXPRESSION OF INTERLEUKIN-4 IN PATIENTS WITH DEVELOPING CHRONIC TRAUMATIC OSTEOMYELITIS

Медицинская иммунология, 2018
Our aim was to study the influence of IL4-589C>T gene polymorphism on IL-4 expression in patients, living in Zabaikalsky Region with a diagnosis of chronic traumatic osteomyelitis developing after fractures of long bones of extremities.The study ...
A. M. Miromanov, O. B. Mironova, N. A. Miromanova   +2 more
doaj   +1 more source

FEATURES OF INTERLEUKIN-2 AND INTERLEUKIN-4 PRODUCTION AND RECEPTION IN AUTOIMMUNE THYROID DISORDERS

Медицинская иммунология, 2014
. The aim of this study was to evaluate some immunopathogenic features of autoimmune thyropathies (autoimmune thyroiditis and Graves’ disease), in terms of IL-2 and IL-4 production and expression of specific surface receptors on blood lymphocytes.
T. V. Saprina
doaj   +1 more source

Biological Therapy of Severe Asthma with Dupilumab, a Dual Receptor Antagonist of Interleukins 4 and 13

Vaccines, 2022
Interleukin-4 (IL-4) and interleukin-13 (IL-13) are key cytokines involved in the pathophysiology of both immune-inflammatory and structural changes underlying type 2 asthma.
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Giuseppe Armentaro, Cecilia Calabrese, Angela Sciacqua, Luca Gallelli, Alessandro Vatrella   +8 more
doaj   +1 more source

PROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS

Медицинская иммунология, 2014
. The main objective of this work was to identify allelic variants of cytokine genes at the polymorphic positions of G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, and C-592A IL-10, and to assess their contribution to predisposition and resistance ...
V. V. Avdoshina, V. V. Dortman, V. I. Konenkov, E. V. Beloborodova, N. V. Ryasantseva, I. O. Naslednikova, V. V. Novitsky   +6 more
doaj   +1 more source

The influence of sepsis as a complication after trauma on immune response to injury [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2011
Introduction. Mortality rate in trauma complicated with sepsis is exceeding 50%. Outcome is not determined only by infection or trauma, but also by the intensity of immuno-inflammatory response. Objective.
Šurbatović Maja, Mirković Darko, Radaković Sonja S., Jevtić Miodrag, Filipović Nikola S.   +4 more
doaj   +1 more source