Results 1 to 10 of about 13,521,848 (335)
Interleukin (IL-6) Immunotherapy [PDF]
Cold Spring Harbor Perspectives in Biology, 2017 Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and contributes to host defense against such emergent stress through activation of acute-phase and immune responses.
Toshio, Tanaka +2 more
openaire +3 more sources
The role of IL-6 and IL-6 blockade in COVID-19 [PDF]
Expert Review of Clinical Immunology, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a dysregulated hyperinflammatory response.Authors review evidence on IL-6 and IL-6 blockade in coronavirus disease 2019 (COVID-19) and discuss the pathophysiological and prognostic roles of this cytokine and the clinical impact of pharmacological blockade of IL-6 .
Nicola Potere +7 more
openaire +6 more sources
A Potential Role of IL-6/IL-6R in the Development and Management of Colon Cancer
Membranes, 2021 Colorectal cancer (CRC) is the third most frequent cancer worldwide and the second greatest cause of cancer deaths. About 75% of all CRCs are sporadic cancers and arise following somatic mutations, while about 10% are hereditary cancers caused by ...
Mimmo Turano +4 more
doaj +1 more source
Frontiers in Medicine, 2022 BackgroundThe use of IL-6 blockers in COVID-19 hospitalized patients has been associated with a reduction in mortality compared to standard care. However, many uncertainties remain pertaining to optimal intervention time, administration schedule, and ...
Rosario García-Vicuña +15 more
doaj +1 more source
International Journal of Infectious Diseases, 2022 Objectives: This study aimed to assess if tocilizumab (TCZ) timing is associated with improved survival. Material and methods: Data obtained from adult patients with moderate/severe/critical COVID-19 and treated with TCZ, who were admitted to the ...
Amanda Radulescu +2 more
doaj +1 more source
Indonesian Journal of Chemistry, 2023 The objective of this study was to assess the predictive value of inflammatory biomarkers in COVID-19 patients, namely the CRP/albumin ratio (CAR), interleukin 6 (IL-6), IL-6/lymphocyte ratio (IL-6/LY), and neutrophil/lymphocyte ratio (NLR).
Agustin Iskandar +6 more
doaj +1 more source
Interleukin-6 mediates delirium-like phenotypes in a murine model of urinary tract infection
Journal of Neuroinflammation, 2021 Background Urinary tract infection (UTI) is frequently implicated as a precipitant of delirium, which refers to an acute confusional state that is associated with high mortality, increased length of stay, and long-term cognitive decline. The pathogenesis
Mohammad Harun Rashid +8 more
doaj +1 more source
Evaluation of serum levels of interleukins 6, 8, 17 and 22 in acne vulgaris: A cross-sectional study
Indian Journal of Dermatology, 2023 Background: Acne vulgaris (AV) is a chronic, multifactorial, inflammatory skin disease, and it is now becoming increasingly clear that the inflammatory pathway is involved at a very early in the pathogenesis of acne.
Sweta Singh +2 more
doaj +1 more source
Serum IL–1β, IL–2, IL–6, and IL–8 levels in schizophrenia subtypes
Psychiatry and Clinical Psychopharmacology, 2021 Objective: The cytokines are considered to be an important topic in immunological studies of schizophrenia. In this clinical study IL-1β, IL-2, IL-6, and IL-8 levels were compared among schizophrenia subtypes and a control group.
Murat Kuloglu +4 more
doaj +1 more source
The Role of Interleukin-6, and IL-12+p40 in the Development of Ischemic Heart Disease
Kufa Journal for Nursing Sciences, 2023 Background: Because low-grade inflammation may play a role in the pathogenesis of coronary heart disease, and pro-inflammatory cytokines govern inflammatory cascades leading to atherosclerosis, and then to ischemic heart disease.
Dina A. A. Al-Roubaey +4 more
doaj +1 more source