The effect of carbohydrate ingestion on the Interleukin-6 response to a 90-minute run time trial [PDF]
, 2009 Fatigue is a predictable outcome of prolonged physical activity; yet its biological cause remains uncertain. During exercise, a polypeptide messenger molecule interleukin- 6 (IL-6) is actively produced.
Ansley, Les +3 more
core +1 more source
Atherosclerosis Plus, 2023 Background and aims: Lipoprotein(a) [Lp(a)] and interleuking-6 (IL-6), an inflammation biomarker, have been established as distinct targets of the residual atherosclerotic cardiovascular disease (ASCVD) risk.
Anastasios Makris +6 more
doaj +1 more source
IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function. [PDF]
, 2019 Objective: We have previously shown that increased circulating interleukin-6 (IL-6) results in enhanced CD4+ T cell signaling via signal transduction and activator of transcription-3 (STAT3) in early rheumatoid arthritis (RA).
Aletaha +33 more
core +2 more sources
IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation
Frontiers in Immunology, 2022 Elevated levels and enhanced sensing of the pro-inflammatory cytokine interleukin-6 (IL-6) are key features of many autoimmune and inflammatory diseases.
Katharina Lambert +11 more
doaj +1 more source
The IL-6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention. [PDF]
, 2017 We recently reported that interleukin-6 (IL-6), an inflammatory marker associated with breast pathology and the development of breast cancer, decreases with diet intervention and weight loss in both insulin-sensitive and insulin-resistant obese women ...
Flatt, Shirley W +6 more
core +2 more sources
Interleukin-6 (IL-6) Production by Astrocytes: Autocrine Regulation by IL-6 and the Soluble IL-6 Receptor [PDF]
The Journal of Neuroscience, 1999 In the CNS, astrocytes are a major inducible source of interleukin-6 (IL-6). Although IL-6 has beneficial effects in the CNS because of its neurotrophic properties, its overexpression is generally detrimental, adding to the pathophysiology associated with CNS disorders.
N J, Van Wagoner +3 more
openaire +2 more sources
In vivo Neutralization of Pro-inflammatory Cytokines During Secondary Streptococcus pneumoniae Infection Post Influenza A Virus Infection [PDF]
, 2019 An overt pro-inflammatory immune response is a key factor contributing to lethal pneumococcal infection in an influenza pre-infected host and represents a potential target for therapeutic intervention.
Boehme, Julia D. +8 more
core +1 more source
The role of serum IL-6 changes in evaluation of endometriosis
مجلة كلية الطب, 2013 Background:- Endometriosis is a common chronic gynecological disorder characterized by the presence and proliferation of functional endometrial gland and stroma outside the uterine cavity, affecting approximately 10% of reproductive age women. Il-6 level
Tharwa H. Hassan AL-Tai +2 more
doaj +1 more source
Fetal and early neonatal interleukin-6 response [PDF]
, 2015 In 1998, a systemic fetal cytokine response, defined as a plasma interleukin-6 (IL-6) value above 11 pg/mL, was reported to be a major independent risk factor for the subsequent development of neonatal morbid events even after adjustments for gestational
B. Resch +5 more
core +1 more source
Phenotypic and Functional Heterogeneity of Low-Density and High-Density Human Lung Macrophages
Biomedicines, 2021 Background: Pulmonary macrophages are a highly heterogeneous cell population distributed in different lung compartments. Methods: We separated two subpopulations of macrophages from human lung parenchyma according to flotation over density gradients ...
Barbara Balestrieri +8 more
doaj +1 more source