EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer
Advanced Science, EarlyView.This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv +8 more
wiley +1 more source
Tuning toxicity profiles of graphene oxide through imidazole-oxime modification: zebrafish as a model system [PDF]
Serkan Yıldırım +10 more
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Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder
Advanced Science, EarlyView.NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai +13 more
wiley +1 more source
Generation of multimillion chemical space based on the parallel Groebke–Blackburn–Bienaymé reaction
Beilstein Journal of Organic ChemistryParallel Groebke–Blackburn–Bienaymé reaction was evaluated as a source of multimillion chemically accessible chemical space. Two most popular classical protocols involving the use of Sc(OTf)3 and TsOH as the catalysts were tested on a broad substrate ...
Evgen V. Govor +7 more
doaj +1 more source
Diaquabis(5-carboxy-2-propyl-1H-imidazole-4-carboxylato-κ2N3,O4)cobalt(II) 3.5-hydrate [PDF]
, 2010 Shijie Li +4 more
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Advanced Science, EarlyView.This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun +12 more
wiley +1 more source
Top‐Down Fabricated Wood‐Derived Pressure and Strain Sensors: A Review
Advanced Science, EarlyView.This review focuses on wood‐derived pressure/strain sensors fabricated via top‐down strategies. It analyzes wood's structural composition, examines processing techniques, discusses sensor types and sensing mechanisms, and reviews existing research. The article concludes with future directions for enhancing performance and scalability.
Yi Ren +8 more
wiley +1 more source
Smart Hydrogel Doped by Metal–Organic Frameworks for Renewable Self‐Pumping Enzymatic Reactors
Advanced Science, EarlyView.Renewable self‐pumping enzymatic reactors based on thermo‐stimulated cyclic contraction/expansion of metal‐organic frameworks‐doped hydrogel. Abstract The construction of high‐performance immobilized enzymes is vastly desired for green biotransformation.
Yuxi Zhu +7 more
wiley +1 more source
(IMIDAZOLE-5-YL)YLIDENTHIAZOLIDONES: A NEW CLASS OF ANTIMICROBIAL AGENTS FOR FOOD INDUSTRY
Food and Environment Safety, 2019 An antimicrobial and antifungal activity of new derivatives of (imidazole-5-yl)ylidenthiazolidinones and its dependence on the substance structure and the type of substitutes in the imidazole and thiazole nucleus have been investigated. It was found that
Vitaliy CHORNOUS +4 more
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