Results 111 to 120 of about 2,073 (211)

Building Multivalent Iminosugar-Based Ligands on Calixarene Cores via Nitrone Cycloadditions

, 2012
A novel and challenging approach for the construction of multivalent iminosugar architectures directly on calixarene scaffolds is presented, which exploits multiple cycloaddition reactions of a carbohydrate-derived nitrone on diversely functionalized ...
SANSONE, Francesco, CASNATI, Alessandro, G. Isoldi, A. Goti, F. Cardona, Goti, Andrea, Cardona, Francesca   +6 more
core   +1 more source

The synthesis of branched sugars and iminosugars

, 2011
Iminosugars, carbohydrate analogues in which nitrogen replaces the endocyclic oxygen, have attracted much interest due to their biological activity. Iminosugars inhibit carbohydrate-processing enzymes, thereby affecting many biological processes. Several iminosugars are licensed drugs, with many more compounds undergoing clinical trials.
openaire   +1 more source

Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial

Clinical Interventions in Aging, 2018
Robert J Nash,1 Boris KG Azantsa,2 Hazel Sharp,1 Velmurugan Shanmugham31PhytoQuest Limited, Plas Gogerddan, Aberystwyth, Ceredigion, UK; 2Department of Biochemistry, University of Yaoundé I, Yaoundé, Cameroon; 3Samrat Research Institute ...
Nash RJ, Azantsa BKG, Sharp H, Shanmugham V   +3 more
doaj  

Synthesis and Evaluation of Iminosugar-Based Analogs of UDP-GlcNAc as Putative OGT Inhibitors. [PDF]

ChemMedChem
Auberger N, Tran TV, Lemaire Q, Busmann J, Lacritick M, Mortuaire M, Schulz C, Vercoutter-Edouart AS, Pâris A, Vocadlo D, Lafite P, Vincent SP, Lefebvre T, Blériot Y.   +13 more
europepmc   +1 more source

Prism[5]arene Iminosugar Bioconjugates Are Potent Multivalent Inhibitors and Mutation Specific Pharmacological Chaperones of Glucocerebrosidase (GCase) Activity. [PDF]

Bioconjug Chem
Palmieri A, Clemente F, Ignoto MM, Buonsenso F, Attanasio M, De Rosa M, Talotta C, Della Sala P, Del Regno R, Iuliano V, Morrone A, Cardona F, Goti A, Matassini C, Gaeta C.   +14 more
europepmc   +1 more source

Ring opening, conformational analysis and NagZ inhibition of a GlcNAc-configured iminosugar-derived aziridine. [PDF]

Carbohydr Res
Auberger N, El-Araby AM, Van Tran T, Feltzer R, Poveda A, Jiménez-Barbero J, Mobashery S, Blériot Y.   +7 more
europepmc   +1 more source

Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers. [PDF]

J Enzyme Inhib Med Chem, 2023
Vaaland IC, López Ó, Puerta A, Fernandes MX, Padrón JM, Fernández-Bolaños JG, Sydnes MO, Lindbäck E.   +7 more
europepmc   +1 more source

A 16 × 8 Focused Compound Library Comprising All Configurational Isomers of the Archetypal Iminosugar, 1-Deoxynojirimycin. [PDF]

J Med Chem
van den Berg RJBHN, van den Nieuwendijk AMCH, Liu B, Ferraz MJ, Ouairy CMJ, Ghisaidoobe AT, Ma Q, van den Elst H, Strijland A, Donker-Koopman WE, Verhoek M, Rijpkema KJ, Boot RG, Wennekes T, van der Marel GA, van Boeckel CAA, Artola M, Aerts JMFG, Overkleeft HS.   +18 more
europepmc   +1 more source

Miglustat in Neuronopathic Lysosomal Storage Disorders: Biological Rationale, Clinical Evidence, and Limits of Repurposing. [PDF]

Int J Mol Sci
Lipiński P, Węgrzyn G.
europepmc   +1 more source

β-d-Arabinofuranose-configured Cyclitol Aziridines as Selective, Brain-penetrant Covalent GBA2 Inhibitors. [PDF]

J Am Chem Soc
Lammers RF, Su Q, Mazo L, A Offen W, Ottenhoff R, Bulterman MJ, van der Lienden M, Ferraz MJ, Küllmer F, Ilhan Z, van den Elst H, van der Made I, van Roomen CPAA, de Jongh A, van den Nieuwendijk AMCH, Boot RG, Zelcer N, Davies GJ, Rovira C, Overkleeft HS, Aerts JMFG, Artola M.   +21 more
europepmc   +1 more source