Results 101 to 110 of about 2,073 (211)
Experimental and Calculated Vibrational Circular Dichroism Spectra of an Iminosugar Molecule: (2R, 3R, 4R) 1,4-dideoxy-1,4-imino-D-arabinitol Hydrochloride [PDF]
, 2013 The first vibrational circular dichroism (VCD) measurement of a biologically important iminosugar, (2R, 3R, 4R) 1,4-dideoxy-1,4-imino-D ...
Florina Teodorescu +4 more
core
, 2013 International audienceIn view of recent reports of a strong multivalent effect in glycosidase inhibition, a library of β‐CD‐based multivalent iminosugars has been efficiently synthesized by way of CuI‐catalyzed azide–alkyne cycloaddition (CuAAC).
Mena Barragán, Teresa +5 more
core +1 more source
Synthesis of New Iminosugar Derivatives Based on (S)-(1,2,3,6-Tetrahydropyridazin-3-yl)methanol [PDF]
, 2019 (S)-(1,2,3,6-Tetrahydropyridazin-3-yl)methanol was synthesized in two steps by the Diels-Alder reaction of penta-2,4-dien-1-ol with diethyl azodicarboxylate in the presence of (S)-BINOL as chiral catalyst.
Kurbanova, M. M. +3 more
core +1 more source
Evolution of the Total Syntheses of Batzellasides the First Marine Piperidine Iminosugar
Natural Product Communications, 2013 Batzellasides A-C are C -alkylated piperidine iminosugars isolated from a sponge Batzella sp. The first total synthesis of (+)-batzellaside B was achieved by employing a chiral pool approach starting from L-arabinose for the construction of a piperidine ...
Tetsuya Sengoku +3 more
doaj +1 more source
, 2000 Both enantiomers of isofagomine, the potent glycosidase inhibitor of a type 1-N-iminosugar have been synthesized by the intramolecular cyclization of the PET generated α-trimethylsilylmethylamine radical cation with the appropriate tethered acetylene ...
Ganesh Pandey +3 more
core +1 more source
Total asymmetric syntheses of iminosugars
, 2015 This thesis is concerned with the development of ring-closing iodoamination and ringexpansion methodology and its subsequent application to the asymmetric syntheses of pyrrolidine and piperidine iminosugars. Chapter 1 highlights the remarkable biological properties displayed by iminosugars and introduces methods for the formation of the pyrrolidine and
Figuccia, A, Figuccia, Aude
openaire +1 more source
A second-generation ferrocene-iminosugar hybrid with improved fucosidase binding properties
, 2016 International audienceThe synthesis and the biological evaluation of a new ferrocenyl-iminosugar conjugate designed for fucosidase inhibitory and anticancer activity is described. The compound showed strong affinity for fucosidase from bovine kidney (Ki =
Scandolera, Amandine +5 more
core +1 more source
Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers
, 2017 A dramatic enhancement in the glycosidase multivalent inhibitory effect was observed while going from a dodecavalent iminosugar ball to the corresponding giant molecule with 120 peripheral subunits.
Schneider, Jérémy +22 more
core +1 more source
A Bis-Glycosylamine Strategy for the Synthesis of Dimeric Iminosugars Based on a DAB-1 Scaffold
MoleculesA straightforward synthetic route towards DAB-1 scaffolded dimeric iminosugars is described here, starting from readily available bis-glycosylamines.
Kamilia Ould Lamara +5 more
doaj +1 more source
Iminosugar-based GCS inhibitors increase Sandhoff mouse survival.
, 2013 Mice were monitored daily from 80 days of age and euthanized when they became moribund and were unable to right themselves from a supine position within 30 sec.
Seng H. Cheng (142952) +12 more
core +1 more source