Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors
Beilstein Journal of Organic Chemistry, 2012 A small set of nojirimycin- and pyrrolidine-based iminosugar derivatives has been synthesized and evaluated as potential inhibitors of porcine and insect trehalases.
Davide Bini +6 more
doaj +1 more source
Biotechnology and Bioengineering, Volume 123, Issue 2, Page 310-323, February 2026.ABSTRACT Clostridioides difficile infection presents an escalating clinical challenge due to the proliferation of hypervirulent and antibiotic‐resistant strains. The primary symptoms of disease, namely colitis and diarrhea, are induced by the release of two toxins: TcdA and TcdB.
Carly M. Catella +10 more
wiley +1 more source
Effects of the selected iminosugar derivatives on Pseudomonas aeruginosa biofilm formation
, 2016 International audienceA lack of an effective way to eliminate pathogenic bacteria hidden in the biofilm is a major problem in treatment of chronic bacterial infections. Iminosugar derivatives are potential candidates for inhibitors of enzymes taking part
Mikołajczyk, Diana +11 more
core +1 more source
Methodology development for the synthesis of iminosugars [PDF]
, 2021 <p>This thesis investigated the development and application of methodology for the synthesis of iminosugars. The first portion of this thesis (Chapters 2 and 3) explored the scope of previously established protecting-group-free Vasella-reductive-amination and I2-mediated carbamate annulation methodology initially developed within the Stocker ...
openaire +1 more source
Stereoselective Access to Iminosugar C, C-Glycosides from 6-Azidoketopyranoses
, 2022 International audienceWe report the synthesis of iminosugar C,C-glycosides starting from 6-azidoketopyranoses. Their Staudinger-azaWittig-mediated cyclization provided bicyclic N,O-acetals, which were stereoselectively opened with AllMgBr to afford β ...
Debbah, Zakaria +9 more
core +1 more source
Bacterial pathogen deploys iminosugar galactosyrin to manipulate plant glycobiology
The extracellular space (apoplast) of plants is an important molecular battleground during infection by many pathogens. We previously found that a plant-secreted β-galactosidase BGAL1 acts in immunity by facilitating the release of immunogenic peptides ...
Sanguankiattichai N +16 more
europepmc +2 more sources
Novel Piperidinyl Iminosugar-Based Nucleosides as Selective Pharmacological Tools
, 2017 Synthesis and applications of Piperidinyl Iminosugar-Based Nucleosides as Selective Pharmacological ...
De Fenza, M. +5 more
core
2-Acetamido-2-deoxy-L-iminosugar C-alkyl and C-aryl glycosides: synthesis and glycosidase inhibition
, 2018 <p>The synthesis of six-membered 2-acetamido L-iminosugar<em>C</em>-alkyl and <em>C</em>-aryl glycosides is reported. </p ...
Arisa Yamamoto +6 more
core +1 more source
The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. [PDF]
, 2003 We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus.
Blumberg, Baruch +6 more
core +1 more source
Glycoside Mimics from Glycosylamines: Recent Progress
Molecules, 2018 Glycosylamines are valuable sugar derivatives that have attracted much attention as synthetic intermediates en route to iminosugar-C-glycosyl compounds.
Cyril Nicolas, Olivier R. Martin
doaj +1 more source