Results 71 to 80 of about 2,073 (211)

2-Acetamido-2-deoxy-D-iminosugar C-glycosides: recent synthetic approaches and perspectives

, 2023
International audienceWhereas iminosugars are ranking among the most powerful glycosidase inhibitors, 1 their promising C-glycoside derivatives have not yet shown their full potential as glycosidase or glycosyltransferase inhibitors.
Désiré, Jérôme, van Tran, Thanh, Foucart, Quentin, Auberger, Nicolas, Blériot, Yves   +4 more
core  

An Australian standard of care for Niemann–Pick disease type C

Internal Medicine Journal, Volume 56, Issue 5, Page 832-848, May 2026.
Abstract Background Niemann–Pick disease type C (NP‐C) is the fifth most prevalent lysosomal disorder in Australia. Diagnostic delay is common, impacted by disease heterogeneity, limited awareness within clinical gateway services and exclusion from state‐based newborn screening programmes.
Michel Tchan, Nicholas Smith, Heidi Peters, Ellie Van Velsen, Catherine Marraffa, Carolyn Ellaway, Katrina Cruz, Shekeeb S. Mohammad, Maina Kava, Joy Yaplito‐Lee, Shanti Balasubramaniam, Yusof Rahman, Brendon Boot, Ashley Bush, Felicity Munro, Leniza Hamoy, Ya Hui Hung, Philippa Johnston, Deanna Carpino, Molly Williams, Sharmila Kiss, Rebecca Quin, Ingrid Sutherland, Mark Walterfang   +23 more
wiley   +1 more source

A diversity oriented one-pot synthesis of novel iminosugar C-glycosides

, 2014
A mild and highly efficient one-pot method has been developed for the stereoselective synthesis of structurally diverse novel iminosugar C-aryl glycosides.
Kumar, Ponminor Senthil, Senthilkumar, Soundararasu, Prasad, Sure Siva, Baskaran, Sundarababu   +3 more
core   +1 more source

Synthesis and Glycosidase Inhibition Properties of Calix[8]arene-Based Iminosugar Click Clusters

Pharmaceuticals, 2020
A set of 6- to 24-valent clusters was constructed with terminal deoxynojirimycin (DNJ) inhibitory heads through C6 or C9 linkers by way of Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions between mono- or trivalent azido-armed iminosugars and
Jérémy P. Schneider, Stefano Tommasone, Paolo Della Sala, Carmine Gaeta, Carmen Talotta, Céline Tarnus, Placido Neri, Anne Bodlenner, Philippe Compain   +8 more
doaj   +1 more source

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, Volume 41, Issue 3, Page 596-602, March 2026.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

Access to l- and d-Iminosugar C-Glycosides from a d-gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy.

, 2012
International audienceA flexible synthetic access to six-membered l- and d-iminosugar C-glycosides is reported starting from the easily available 6-azido-6-deoxy-2,3,4-tri-O-benzyl-d-glucopyranose precursor.
Désiré, Jérôme, Lecornué, Frédéric, Mondon, Martine, Marrot, Jérôme, Guillard, Jérôme, Fontelle, Nathalie, Blériot, Yves   +6 more
core   +1 more source

The transformative power of structural predictions with AI in plant science

The Plant Journal, Volume 125, Issue 6, March 2026.
SUMMARY Since the introduction of various structural prediction programs, the emerging transformative power of these technologies in plant science is apparent. Not only programs like AlphaFold but also RoseTTAFold, Chai‐1 and Boltz suddenly enable plant scientists to predict structures with high confidence. This ability has facilitated the discovery of
Joy Chenqu Lyu, Renier A. L. Van der Hoorn   +1 more
wiley   +1 more source

Access to l- and d-Iminosugar C-Glycosides from a d-gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy

, 2016
A flexible synthetic access to six-membered l- and d-iminosugar C-glycosides is reported starting from the easily available 6-azido-6-deoxy-2,3,4-tri-O-benzyl-d-glucopyranose precursor.
Frédéric Lecornué (2117959), Jérôme Marrot (1395463), Jérôme Désiré (1725307), Jérôme Guillard (1773448), Yves Blériot (1507720), Nathalie Fontelle (2117962), Martine Mondon (2117965)   +6 more
core   +1 more source

Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores

Beilstein Journal of Organic Chemistry, 2015
The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide–alkyne ...
Mathieu L. Lepage, Antoine Mirloup, Manon Ripoll, Fabien Stauffert, Anne Bodlenner, Raymond Ziessel, Philippe Compain   +6 more
doaj   +1 more source

Synthesis of Substituted Cyclic Amines From Protected Amino Acids Using Oxidative Decarboxylation and Alkylation

Asian Journal of Organic Chemistry, Volume 15, Issue 2, February 2026.
Simple access to alkylated 3D scaffold via oxidative radical decarboxylation, trapping of iminium, and successive reaction with organometallic reagent in the presence of BF3 . ABSTRACT Cyclic amines are vital scaffolds in bioactive molecules and drug discovery, often functionalized via electrochemical Shono‐type oxidation to access N‐acyliminium ...
Dario Corbisiero, Arthur F. Rossignol, Francesco Calogero, Andrea Gualandi, Emanuele Pinosa, Luca Sensoli, Paolo Ronchi, Pier Giorgio Cozzi   +7 more
wiley   +1 more source