Results 61 to 70 of about 2,073 (211)

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores

Beilstein Journal of Organic Chemistry, 2014
Cyclic N-propargyl α-peptoids of various sizes were prepared by way of macrocyclizations of linear N-substituted oligoglycines. These compounds were used as molecular platforms to synthesize a series of iminosugar clusters with different valency and ...
Mathieu L. Lepage, Alessandra Meli, Anne Bodlenner, Céline Tarnus, Francesco De Riccardis, Irene Izzo, Philippe Compain   +6 more
doaj   +1 more source

sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below 10% of normal, due to mutations that destabilise the native folded form of the enzyme and impair its trafficking to the lysosome ...
Manuel González-Cuesta, Irene Herrera-González, M. Isabel García-Moreno, Roger A. Ashmus, David J. Vocadlo, José M. García Fernández, Eiji Nanba, Katsumi Higaki, Carmen Ortiz Mellet   +8 more
doaj   +1 more source

Stereoselective Synthesis of Glycomimetic Amines From Biomass‐Derived Cyrene

European Journal of Organic Chemistry, Volume 29, Issue 18, 14 May 2026.
2,3,4‐Trideoxy‐2‐mannosamines, including the unsubstituted one, are accessible as the only endo diastereoisomers by reductive amination of the green solvent Cyrene, derived from pyrolysis of cellulose containing waste biomass. The products are useful chiral synthetic intermediate to nitrogenated glycomimetics.
Debora Pratesi, Marta Rigacci, Francesca Cardona, Camilla Matassini, Andrea Goti   +4 more
wiley   +1 more source

Synthesis and glycosidase inhibition properties of triazole-linked calixarene–iminosugar clusters

, 2014
International audienceCalixarene–iminosugar derivatives bearing four 1-deoxynojirimycin units at the upper or lower rim of calix[4]arenes in a fixed cone conformation were synthesized by copper-catalyzed azide-alkyne cycloaddition (CuAAC) and their ...
La Ferla, Barbara, Marra, Alberto, Dondoni, Alessandro, Marra A., Zelli R., Dondoni A., D'Orazio G., d'Orazio, Giuseppe, La Ferla B., Zelli, Renaud   +9 more
core   +1 more source

Safety assessment of a standardized cucumber extract (Q-Actin™): Oral repeat-dose toxicity and mutagenicity studies

Toxicology Reports, 2018
Cucumus sativus (cucumber) is one of the most widely consumed fruit vegetables worldwide. Recent discovery of iminosugars in commonly consumed fruits and vegetables has promoted the interest in isolating these compounds and understanding the potential ...
S. Kothari, M. Saravana, S. Muthusamy, A. Mozingo, M. Soni   +4 more
doaj   +1 more source

Rapid Microwave‐Assisted Iodination of Glycals to 2‐Iodoglycals Under Operationally Simple Conditions: Next Chapter in (C‐2)‐Functionalisation of Sugar Moieties

Chemistry–Methods, Volume 6, Issue 5, May 2026.
Microwave‐assisted protocol is presented as an alternative method for synthesis of 2‐iodoglycals. These conditions are characterised with the simple reaction setup giving an access to 16 examples of iodinated sugar derivatives including trisaccharide residue or antidiabetic acarbose scaffold.
Dariusz Baran, Agnieszka Ewa Kuklewska, Morgane de Robichon, Bartłomiej Stankiewicz, Karolina Hurej, Aneta Pobudkowska, Andrzej Plichta, Angélique Ferry, Maciej Malinowski   +8 more
wiley   +1 more source

Red Grape Pomace as a Valuable Source of Biomolecules With Inhibitory Effect on Pro‐Inflammatory and Metabolic Syndrome‐Associated Enzymes: Eco‐Friendly Extraction and Mechanism of Inhibition

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Superposition of the top scoring enzyme‐ligand models resulting from the in silico docking tests: complexes formed by α‐amylase (a), α‐glucosidase (b), and lipoxygenase (c) with vanillic acid (magenta), azelaic acid (red), phlorizin (yellow), cis‐polydatin (green), chlorogenic acid (orange), suberic acid (black), abietic acid (blue), t‐resveratrol ...
Nicoleta Balan, Silviu Măntăilă, Ilir Mërtiri, Elisabeta Irina Geana, Iuliana Aprodu, Gabriela Râpeanu, Nicoleta Stănciuc   +6 more
wiley   +1 more source

Intramolecular Palladium-Catalyzed Carboamination for the Stereoselective Synthesis of Five-Membered Iminosugar C‑Glycosides

, 2022
We report here a new method for the stereoselective synthesis of five-membered iminosugar C-glycosides using an intramolecular palladium-catalyzed carboamination.
Olivier R. Martin (204927), Estelle Gallienne (2652355), Salia Tangara (4405978), Sophie Front (204924)   +3 more
core   +1 more source

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source