Results 41 to 50 of about 2,073 (211)

PDIA, an Iminosugar Compound with a Wide Biofilm Inhibitory Spectrum Covering Both Gram-Positive and Gram-Negative Human Bacterial Pathogens

Microorganisms, 2022
Many difficult-to-treat human infections related to catheters and other indwelling devices are caused by bacteria residing in biofilms. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial ...
Łucja Kozień, Estelle Gallienne, Olivier Martin, Sophie Front, Magdalena Strus, Piotr Heczko   +5 more
doaj   +1 more source

Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies

Journal of Enzyme Inhibition and Medicinal Chemistry
We developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of glycosidase inhibitors (α-glucosidase, α-galactosidase ...
Zorana Ferjancic, Filip Bihelovic, Bojan Vulovic, Radomir Matovic, Milena Trmcic, Aleksandar Jankovic, Milos Pavlovic, Filip Djurkovic, Radivoje Prodanovic, Aleksandra Djurdjevic Djelmas, Nevena Kalicanin, Mario Zlatovic, Dusan Sladic, Thomas Vallet, Marco Vignuzzi, Radomir N. Saicic   +15 more
doaj   +1 more source

Fluorinated Iminosugar Glycomimetics: Synthesis and Activity as GCase Ligands

European Journal of Organic Chemistry, EarlyView.
DAST‐mediated deoxyfluorination of suitably functionalized piperidines provided regio‐ and stereoselective access to fluorinated piperidine and pyrrolidine glycomimetics, the latter arising from an unusual ring‐contraction process. Fluorination generally enhanced β‐glucocerebrosidase (GCase) inhibitory potency, but lost PC activity toward L444P/L444P ...
Francesca Mangiavacchi, Alessio Morano, Cosimo Margheri, Cristina Faggi, Amelia Morrone, Camilla Matassini, Francesca Clemente, Andrea Goti, Martina Cacciarini, Francesca Cardona   +9 more
wiley   +1 more source

GM3 inhibition in MDMΦ by treatment with MNTD iminosugar concentrations.

, 2016
GM3 inhibition in MDMΦ by treatment with MNTD iminosugar concentrations.
Eva Harris (27355), Alessandro T. Caputo (3180210), Kyoko Kinami (1608367), P. Robert Beatty (253230), Sarah S. Killingbeck (3180222), Michelle L. Hill (329880), Joanna L. Miller (3180228), Beatrice E. Tyrrell (3180219), Nicole Zitzmann (90474), Atsushi Kato (264067), J. L. Kiappes (2178494), Andrew C. Sayce (3180216), Ren Iwaki (3180213), Raymond A. Dwek (156053), Daisuke Ide (3180225), Dominic S. Alonzi (1297545)   +15 more
core   +1 more source

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp²-Iminosugar Glycolipids

Molecules, 2019
The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby behaving as true carbohydrate chemical mimics.
Elena M. Sánchez-Fernández, M. Isabel García-Moreno, Raquel García-Hernández, José M. Padrón, José M. García Fernández, Francisco Gamarro, Carmen Ortiz Mellet   +6 more
doaj   +1 more source

Natural iminosugar (+)-lentiginosine inhibits ATPase and chaperone activity of hsp90. [PDF]

PLoS ONE, 2012
Heat shock protein 90 (Hsp90) is a significant target in the development of rational cancer therapy due to its role at the crossroads of multiple signaling pathways associated with cell proliferation and cell viability.
Fabrizio Dal Piaz, Antonio Vassallo, Maria Giovanna Chini, Franca M Cordero, Francesca Cardona, Claudio Pisano, Giuseppe Bifulco, Nunziatina De Tommasi, Alberto Brandi   +8 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Correction: Iminosugars as glycosyltransferase inhibitors

Organic & Biomolecular Chemistry, 2021
Correction for ‘Iminosugars as glycosyltransferase inhibitors’ by Irene Conforti, et al. , Org. Biomol. Chem. , 2021, DOI: 10.1039/D1OB00382H.
Irene Conforti, Alberto Marra
openaire   +2 more sources

A new approach toward the total synthesis of (+)-batzellaside B

Beilstein Journal of Organic Chemistry, 2012
A new synthetic approach to (+)-batzellaside B from naturally abundant L-pyroglutamic acid is presented in this article. The key synthetic step involves Sharpless asymmetric dihydroxylation of an olefinic substrate functionalized with an acetoxy group to
Jolanta Wierzejska, Shin-ichi Motogoe, Yuto Makino, Tetsuya Sengoku, Masaki Takahashi, Hidemi Yoda   +5 more
doaj   +1 more source

Determination of protonation states of iminosugar-enzyme complexes using photoinduced electron transfer [PDF]

, 2017
N-alkylated analogues of 1-deoxynojirimycin inhibit β-glucosidase from white rot fungus. The amino group in the β-glucosidase–iminosugar complex is unprotonated when bound, while an active site carboxylate is protonated.
Wang, Bo, Olsen, Jacob Ingemar, Mikael Bols, Bo W. Laursen, Bo Wang, Bols, Mikael, Jacob Ingemar Olsen, Laursen, Bo W., Poulsen, Jens Christian Navarro, Jens Christian Navarro Poulsen   +9 more
core   +1 more source