Results 31 to 40 of about 2,073 (211)

Synthesis of Piperidine Nucleosides as Conformationally Restricted Immucillin Mimics

Molecules, 2021
The de novo synthesis of piperidine nucleosides from our homologating agent 5,6-dihydro-1,4-dithiin is herein reported. The structure and conformation of nucleosides were conceived to faithfully resemble the well-known nucleoside drugs Immucillins H and ...
Maria De Fenza, Anna Esposito, Daniele D’Alonzo, Annalisa Guaragna   +3 more
doaj   +1 more source

N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides

Journal of Lipid Research, 2007
Peracetylated N-α-azidoacetylmannosamine (Ac4ManNAz) is metabolized by cells to CMP-azidosialic acid. It has been demonstrated previously that in this way azidosialic acid-containing glycoproteins are formed that can be labeled on the cell surface by a ...
Anton P. Bussink, Paul F. van Swieten, Karen Ghauharali, Saskia Scheij, Marco van Eijk, Tom Wennekes, Gijs A. van der Marel, Rolf G. Boot, Johannes M.F.G. Aerts, Herman S. Overkleeft   +9 more
doaj   +1 more source

Iminosugar antivirals: the therapeutic sweet spot [PDF]

Biochemical Society Transactions, 2017
Many viruses require the host endoplasmic reticulum protein-folding machinery in order to correctly fold one or more of their glycoproteins. Iminosugars with glucose stereochemistry target the glucosidases which are key for entry into the glycoprotein folding cycle.
Alonzi, D, Scott, K, Dwek, R, Zitzmann, N   +3 more
openaire   +2 more sources

Developments in Carbohydrate-Based Cancer Therapeutics

Pharmaceuticals, 2019
Cancer cells of diverse origins express extracellular tumor-specific carbohydrate antigens (TACAs) because of aberrant glycosylation. Overexpressed TACAs on the surface of tumor cells are considered biomarkers for cancer detection and have always been ...
Farzana Hossain, Peter R. Andreana
doaj   +1 more source

Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease. [PDF]

PLoS ONE, 2011
The neuropathic glycosphingolipidoses are a subgroup of lysosomal storage disorders for which there are no effective therapies. A potential approach is substrate reduction therapy using inhibitors of glucosylceramide synthase (GCS) to decrease the ...
Karen M Ashe, Dinesh Bangari, Lingyun Li, Mario A Cabrera-Salazar, Scott D Bercury, Jennifer B Nietupski, Christopher G F Cooper, Johannes M F G Aerts, Edward R Lee, Diane P Copeland, Seng H Cheng, Ronald K Scheule, John Marshall   +12 more
doaj   +1 more source

The Synthesis of Glycosidase Substrates: Iminosugar, Hyaluronic Acid, & Chondroitin Sulfate Derivatives.

, 2010
The Synthesis of Glycosidase Substrates: Iminosugar, Hyaluronic Acid, & Chondroitin Sulfate ...
Mark. Kinch (7967300)
core   +3 more sources

Synthesis of pyrrolidine-based hamamelitannin analogues as quorum sensing inhibitors in Staphylococcus aureus

Beilstein Journal of Organic Chemistry, 2018
Interfering with bacterial cell-to-cell communication is a promising strategy to combat antimicrobial resistance. The natural product hamamelitannin and several of its analogues have been identified as quorum sensing inhibitors.
Jakob Bouton, Kristof Van Hecke, Reuven Rasooly, Serge Van Calenbergh   +3 more
doaj   +1 more source

Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia

Molecules, 2022
(1) Background. Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to ...
Olumayokun A. Olajide, Victoria U. Iwuanyanwu, Owolabi W. Banjo, Atsushi Kato, Yana B. Penkova, George W. J. Fleet, Robert J. Nash   +6 more
doaj   +1 more source

Synthesis and Therapeutic Applications of Iminosugars in Cystic Fibrosis [PDF]

International Journal of Molecular Sciences, 2020
Iminosugars are sugar analogues endowed with a high pharmacological potential. The wide range of biological activities exhibited by these glycomimetics associated with their excellent drug profile make them attractive therapeutic candidates for several medical interventions.
Anna Esposito, Daniele D’Alonzo, Maria De Fenza, Eliana De Gregorio, Anna Tamanini, Giuseppe Lippi, Maria Cristina Dechecchi, Annalisa Guaragna   +7 more
openaire   +4 more sources

Borylated 5-Membered Ring Iminosugars: Detailed Nuclear Magnetic Resonance Spectroscopic Characterisation, and Method for Analysis of Anomeric and Boron Equilibria

Molecules
This paper describes the first detailed NMR analysis of the borylated intermediates and target compounds for a small library of pyrrolidine iminosugars of l-gulose absolute stereochemical configuration.
Michela Simone
doaj   +1 more source