Results 91 to 100 of about 2,073 (211)
, 2014 Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkablemultivalency properties when inhibiting alpha-mannosidase activity.
MENA BARRAGÁN, Teresa +9 more
core +1 more source
Antileishmanial activity of sp2-iminosugar derivatives [PDF]
, 2015 A series of sp2-iminosugar-type glycomimetics bearing S-linked pseudoglycoside substituents (sulfide, sulfoxide and sulfone derivatives) has been synthesized and evaluated as new potential drugs against the protozoan parasite Leishmania, responsible of
García Hernández, Raquel +12 more
core +1 more source
Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.
PLoS ONE, 2012 The iminosugar N-(5'-adamantane-1'-yl-methoxy)-pentyl-1-deoxynoijirimycin (AMP-DNM), an inhibitor of glycosphingolipid (GSL) biosynthesis is known to ameliorate diabetes, insulin sensitivity and to prevent liver steatosis in ob/ob mice.
Elisa Lombardo +11 more
doaj +1 more source
The mechanism of action of iminosugars as antiretrovirals
, 2014 Iminosugars are a class of molecules that resemble sugars but for the substitution of a nitrogen for the oxygen in the hemiacetal ring. Several iminosugars are inhibitors of cellular glycosidase enzymes in the N-linked glycan processing pathway. Iminosugars inhibiting endoplasmic reticulum (ER) α-glucosidases are known to be antiviral against a broad ...
Spiro, S, Spiro, Simon
openaire +2 more sources
, 2015 We herein describe the first synthesis of iminosugar C-glycosides of α-d-GlcNAc-1-phosphate in 10 steps starting from unprotected d-GlcNAc. A diastereoselective intramolecular iodoamination–cyclization as the key step was employed to construct the ...
Yi-Fan Chang (1335882) +8 more
core +1 more source
The synthesis and biology of iminosugars and their precursors
, 2014 Iminosugars are carbohydrate mimics, where the endocyclic ring oxygen has been replaced by nitrogen. This substitution affords these compounds their inhibitory activity towards sugar-processing enzymes (glycosidases) and, as a consequence, their chemotherapeutic potential in the treatment of a broad range of diseases.
Ayers, Benjamin James, Ayers, Benjamin
openaire +1 more source
Synthetic Iminosugar Derivatives as New Potential Immunosuppressive Agents
, 2016 Several iminosugar derivatives were synthesized, and their effects on the secretion of IL-4 and IFN-γ from the mouse splenocytes were examined. The effects on membrane expression of other T cell-associated molecules (CD3, CD4, CD8) and B cell-associated ...
Xin-Shan Ye (1393843) +7 more
core +1 more source
Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
Beilstein Journal of Organic Chemistry, 2015 The synthesis of new multivalent architectures based on a trihydroxypiperidine α-fucosidase inhibitor is reported herein. Tetravalent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne ...
Camilla Matassini +5 more
doaj +1 more source
, 2014 International audienceA convergent strategy to access high‐valency iminosugar clusters based on two successive CuI‐catalysed azide–alkyne cycloadditions is reported. The key step of this approach relies on the grafting of azide‐armed trivalent iminosugar
Compain, Philippe +5 more
core +1 more source
, 2018 International audienceThe multivalent effect in glycosidase inhibition is a new topic in glycoscience that has emerged a few years ago, with the discovery of neoglycoclusters displaying strong binding enhancements over the corresponding monovalent ...
García-Moreno, M. Isabel +19 more
core +1 more source