Results 1 to 10 of about 2,560 (131)

Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar [PDF]

Beilstein Journal of Organic Chemistry, 2015
The synthesis of new multivalent architectures based on a trihydroxypiperidine α-fucosidase inhibitor is reported herein. Tetravalent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne ...
Camilla Matassini, Stefania Mirabella, Andrea Goti, Inmaculada Robina, Antonio J. Moreno-Vargas, Francesca Cardona   +5 more
doaj   +6 more sources

Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance [PDF]

Molecules, 2022
Recently, the strategy of multivalency has been widely employed to design glycosidase inhibitors, as glycomimetic clusters often induce marked enzyme inhibition relative to monovalent analogs.
Yali Wang, Jian Xiao, Aiguo Meng, Chunyan Liu   +3 more
doaj   +2 more sources

Food Iminosugars and Related Synthetic Derivatives Shift Energy Metabolism and Induce Structural Changes in Colon Cancer Cell Lines [PDF]

Foods
Iminosugars have a carbohydrate-like backbone in which the ring oxygen is replaced by nitrogen. They are naturally found in foods such as rice, buckwheat, mulberries, and fermented vegetables, and are reported to exert anti-hyperlipidemic and anti ...
Thomas Montebugnoli, Charlotte Grootaert, Alessandra Bordoni, Andreja Rajković, Elien Alderweireldt, Jeltien Rombaut, Sofie L. De Maeseneire, John Van Camp, Maarten Lieven De Mol   +8 more
doaj   +2 more sources

Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays [PDF]

Pathogens, 2023
Crimean-Congo haemorrhagic fever virus (CCHFV) is a pathogen of increasing public health concern, being a widely distributed arbovirus and the causative agent of the potentially fatal Crimean-Congo haemorrhagic fever. Hazara virus (HAZV) is a genetically
Beatrice E. Tyrrell, Abhinav Kumar, Bevin Gangadharan, Dominic Alonzi, Juliane Brun, Michelle Hill, Tehmina Bharucha, Andrew Bosworth, Victoria Graham, Stuart Dowall, Joanna L. Miller, Nicole Zitzmann   +11 more
doaj   +2 more sources

Borylated 5-Membered Ring Iminosugars: Synthesis and Biological Evaluation for Glycosidase Inhibition and Anticancer Properties for Application in Boron Neutron Capture Therapy (BNCT)—Part 2 [PDF]

Pharmaceuticals
Background: The synthesis and biological investigation of pyrrolidine (L-gulo) iminosugars bearing an organic boron pharmacophore in ortho and meta positions of an N-benzyl group is reported.
Kate Prichard, Kosuke Yoshimura, Suzuka Yamamoto, Atsumi Taguchi, Barbara Bartholomew, Jayne Gilbert, Jennette Sakoff, Robert Nash, Atsushi Kato, Michela Simone   +9 more
doaj   +2 more sources

Expanding horizons of iminosugars as broad-spectrum anti-virals: mechanism, efficacy and novel developments [PDF]

Natural Products and Bioprospecting
Iminosugars, a class of polyhydroxylated cyclic alkaloids with intriguing properties, hold promising therapeutic potentials against a broad spectrum of enveloped viruses, including DENV, HCV, HIV, and influenza viruses.
Qiantong Liu, Yanyun Liu, Tingting Liu, Jinbao Fan, Zanxian Xia, Yingjun Zhou, Xu Deng   +6 more
doaj   +2 more sources

A Bis-Glycosylamine Strategy for the Synthesis of Dimeric Iminosugars Based on a DAB-1 Scaffold [PDF]

Molecules
A straightforward synthetic route towards DAB-1 scaffolded dimeric iminosugars is described here, starting from readily available bis-glycosylamines.
Kamilia Ould Lamara, Nathan Noël, Fabien Massicot, Jean-Luc Vasse, Stéphane P. Vincent, Jean-Bernard Behr   +5 more
doaj   +2 more sources

Borylated Five-Membered Ring Iminosugars: Synthesis, Spectroscopic Analysis, and Biological Evaluation for Glycosidase Inhibition and Anticancer Properties for Application in Boron Neutron Capture Therapy (BNCT)—Part 1 [PDF]

Pharmaceuticals
Background/Objectives: This article reports pyrrolidine iminosugars of L-gulose absolute stereochemical configuration that are functionalised via N-alkylation to bear boronate ester and boronic acid pharmacophores.
Kate Prichard, Suzuka Yamamoto, Yuna Shimadate, Kosuke Yoshimura, Barbara Bartholomew, Jayne Gilbert, Jennette Sakoff, Robert Nash, Atsushi Kato, Michela Simone   +9 more
doaj   +2 more sources

One-Pot Synthesis of Hydroxylated Alkaloids from Sugars via a Pictet–Spengler-Type Reaction [PDF]

Molecules
An efficient and convenient strategy has been successfully developed for the preparation of novel hydroxylated alkaloid derivatives (also called fused multicyclic iminosugars) from p-toluenesulfonylated sugars through a Pictet–Spengler-type mechanism ...
Likai Zhou, Na Ma, Jilai Wu, Weilin Yang, Lijing Feng, Song Xie, Lili Wang, Hua Chen   +7 more
doaj   +2 more sources

Borylated 5-Membered Ring Iminosugars: Detailed Nuclear Magnetic Resonance Spectroscopic Characterisation, and Method for Analysis of Anomeric and Boron Equilibria [PDF]

Molecules
This paper describes the first detailed NMR analysis of the borylated intermediates and target compounds for a small library of pyrrolidine iminosugars of l-gulose absolute stereochemical configuration.
Michela Simone
doaj   +2 more sources