Results 31 to 40 of about 1,989,151 (330)
Immune checkpoint inhibitors for multiple myeloma immunotherapy
Experimental Hematology & Oncology, 2023 Multiple myeloma (MM) is related to immune disorders, recent studys have revealed that immunotherapy can greatly benefit MM patients. Immune checkpoints can negatively modulate the immune system and are closely associated with immune escape.
Zhaoyun Liu +5 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Targeting myeloid cells represents a promising strategy to augment antitumor immunity and overcome resistance to existing T cell-targeting therapies. However myeloid checkpoints that can be effectively used as immunotherapy targets are still
Itziar Ibarlucea-Benitez +3 more
semanticscholar +1 more source
Immune Checkpoint Inhibitor Toxicities [PDF]
Mayo Clinic Proceedings, 2019 Immune checkpoint inhibitors are molecules that increase the endogenous immune response against tumors. They have revolutionized the field of oncology. Since their initial approval for the treatment of advanced melanoma, their use has expanded to the treatment of several other advanced cancers. Unfortunately, immune checkpoint inhibitors have also been
Julian A. Marin-Acevedo +2 more
openaire +2 more sources
Inhibitory Receptors and Immune Checkpoints Regulating Natural Killer Cell Responses to Cancer
Cancers, 2021 Simple Summary Recent years marked the discovery and increased understanding of the role immune checkpoints play in immunity against cancer. This has revolutionized cancer treatment, saving the lives of many patients.
Irina Buckle, Camille Guillerey
semanticscholar +1 more source
Oncoimmunology, 2021 Different mechanisms lead to immune checkpoint inhibitor (ICI) resistance. Identifying clinically useful biomarkers might improve drug selection and patients’ therapy.
D. Machiraju +9 more
semanticscholar +1 more source
Immune checkpoint blockade therapy [PDF]
Journal of Allergy and Clinical Immunology, 2018 Immune checkpoints are accessory molecules that either promote or inhibit T-cell activation. Two inhibitory molecules, cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), got high attention, as inhibition of CTLA-4 or PD-1 signaling provides the first immune therapy that significantly improves the survival of patients ...
Thomas, Wieder +3 more
openaire +2 more sources
Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors [PDF]
, 2016 PURPOSE: Subsets of pituitary tumors exhibit an aggressive clinical courses and recur despite surgery, radiation, and chemotherapy. Because modulation of the immune response through inhibition of T-cell checkpoints has led to durable clinical responses ...
Agar, Nathalie Y. R. +13 more
core +6 more sources
Immune checkpoints in circulating and tumor-Infiltrating CD4 + T Cell Subsets in Colorectal cancer patients [PDF]
, 2019 Blockade of inhibitory immune checkpoints (ICs) is a promising therapeutic approach; however, it has shown limited success in some cancers including colorectal cancer (CRC). The tumor microenvironment (TME) is largely responsible for response to therapy,
Abu Nada, M +5 more
core +2 more sources
NLRP3 promotes immune escape by regulating immune checkpoints: A pan-cancer analysis.
International Immunopharmacology, 2021 NLRP3 plays a pathogenic role in tumorigenesis by regulating innate and acquired immunity, apoptosis, differentiation, and intestinal microbes in tumors.
Yue Ding +7 more
semanticscholar +1 more source
Biological therapy in the treatment of melanoma [PDF]
, 2018 Melanoma is one of the most aggressive tumors and its incidence is on the rise. The low rates of survival in metastatic melanoma has led to the development of new drugs for this type of patient, such as biological therapy which has shown remarkable ...
Benea, Vasile +8 more
core +3 more sources