Ecm29-Dependent Proteasome Localization Regulates Cytoskeleton Remodeling at the Immune Synapse [PDF]
Frontiers in Cell and Developmental Biology, 2021 The formation of an immune synapse (IS) enables B cells to capture membrane-tethered antigens, where cortical actin cytoskeleton remodeling regulates cell spreading and depletion of F-actin at the centrosome promotes the recruitment of lysosomes to ...
Jorge Ibañez-Vega +7 more
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NKp46 clusters at the immune synapse and regulates NK cell polarization [PDF]
Frontiers in Immunology, 2015 Natural killer cells play an important role in first-line defense against tumor and virus-infected cells. The activity of NK cells is tightly regulated by a repertoire of cell-surface expressed inhibitory and activating receptors.
Uzi eHadad +6 more
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INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control [PDF]
Communications Biology, 2023 The immune synapse, a highly organized structure formed at the interface between T lymphocytes and antigen-presenting cells (APCs), is essential for T cell activation and the adaptive immune response.
Tzu-Yuan Chiu +16 more
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Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes [PDF]
eLife, 2022 Immune synapse formation is a key step for lymphocyte activation. In B lymphocytes, the immune synapse controls the production of high-affinity antibodies, thereby defining the efficiency of humoral immune responses.
Judith Pineau +5 more
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B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction [PDF]
Frontiers in Immunology, 2022 Upon interaction with immobilized antigens, B cells form an immune synapse where actin remodeling and re-positioning of the microtubule-organizing center (MTOC) together with lysosomes can facilitate antigen extraction.
Romina Ulloa +12 more
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Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function [PDF]
Molecular Therapy: OncologyTargeting immune checkpoint receptors on T cells is a common cancer treatment strategy. Frequently, this is accomplished through antibodies targeting the ligand of inhibitory co-receptors.
Luke Yi Hao +10 more
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ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse [PDF]
Frontiers in Immunology, 2022 When killing through the granule exocytosis pathway, cytotoxic lymphocytes release key effector molecules into the immune synapse, perforin and granzymes, to initiate target cell killing.
Jesse A. Rudd-Schmidt +8 more
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Complement controls the immune synapse and tumors control complement [PDF]
Journal for ImmunoTherapy of Cancer, 2020 The synapses between immune cells and their targets are 150 Å wide. They regulate immune cell responses (IRs) to cognate antigens. Here, I outline a potential mechanism for self-nonself discrimination based on the C3d and iC3b proteolytic fragments of ...
Alan Herbert
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Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8+ T cells. [PDF]
Nat Commun, 2023 Calzada-Fraile D +11 more
europepmc +3 more sources
CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells. [PDF]
Cancer Immunol Immunother, 2023 Marcinek A +15 more
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