Results 11 to 20 of about 119,167 (289)

Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy.

PLoS Biology, 2011
Natural Killer (NK) cells are innate immune cells that secrete lytic granules to directly kill virus-infected or transformed cells across an immune synapse.
Alice C N Brown, Stephane Oddos, Ian M Dobbie, Juha-Matti Alakoskela, Richard M Parton, Philipp Eissmann, Mark A A Neil, Christopher Dunsby, Paul M W French, Ilan Davis, Daniel M Davis   +10 more
doaj   +3 more sources

PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation. [PDF]

Blood Adv
Chmiest D, Podavini S, Ioannidou K, Vallois D, Décaillet C, Gonzalez M, Quadroni M, Blackney K, Schairer R, de Leval L, Thome M.   +10 more
europepmc   +3 more sources

EXTH-40. DIPGS SUPPRESS THE EFFICACY OF T CELL THERAPIES THROUGH DYSFUNCTIONAL IMMUNE SYNAPSE FORMATION [PDF]

Neuro Oncol, 2022
Jorge Ibañez-Vega, Haley Houke, Abdul Elayan, Jennifer Ocasio-Adorno, Nikhil Hebbar, Paulina Velasquez, Suzanne J. Baker, Giedre Krenciute   +7 more
europepmc   +3 more sources

Mixed-mobility supported lipid bilayers reveal the modulatory role of immobilized ICAM1 on T cell activation, effector functions and immune synapse organization [PDF]

Leithner A, Kvalvaag A, Mitra T, Valvo S, Dada H, Compeer E, Jenkins E, Lagerholm C, Dushek O, Dustin ML.   +9 more
europepmc   +2 more sources

Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection [PDF]

, 2015
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts.
Borrow, Persephone, Chain, Benjamin M., Groppelli, Elisabetta, Jolly, Clare, Pellegrino, Pierre, Williams, Ian, Zhang, Changwang, Zhou, Shi   +7 more
core   +18 more sources

Potentiating the Antitumor Activity of Cytotoxic T Cells via the Transmembrane Domain of IGSF4 That Increases TCR Avidity

Frontiers in Immunology, 2021
A robust T-cell response is an important component of sustained antitumor immunity. In this respect, the avidity of TCR in the antigen-targeting of tumors is crucial for the quality of the T-cell response.
Hye-Ran Kim, Hye-Ran Kim, Jeong-Su Park, Jeong-Su Park, Yasmin Fatima, Yasmin Fatima, Maiza Kausar, Maiza Kausar, Jin-Hwa Park, Jin-Hwa Park, Chang-Duk Jun, Chang-Duk Jun   +11 more
doaj   +1 more source

B cell mechanosensing regulates ER remodeling at the immune synapse. [PDF]

Front Immunol
Riobó I, Yuseff MI.
europepmc   +3 more sources

Transgelin-2: A Double-Edged Sword in Immunity and Cancer Metastasis

Frontiers in Cell and Developmental Biology, 2021
Transgelin-2, a small actin-binding protein, is the only transgelin family member expressed in immune cells. In T and B lymphocytes, transgelin-2 is constitutively expressed, but in antigen-presenting cells, it is significantly upregulated upon ...
Hye-Ran Kim, Hye-Ran Kim, Jeong-Su Park, Jeong-Su Park, Hatice Karabulut, Hatice Karabulut, Fatima Yasmin, Fatima Yasmin, Chang-Duk Jun, Chang-Duk Jun   +9 more
doaj   +1 more source

Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse

Frontiers in Cell and Developmental Biology, 2021
T cell receptor (TCR) and B cell receptor (BCR) stimulation by antigen presented on an antigen-presenting cell (APC) induces the formation of the immune synapse (IS), the convergence of secretory vesicles from T and B lymphocytes toward the centrosome ...
Victor Calvo, Manuel Izquierdo
doaj   +1 more source

Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse: good, bad, or both?

Frontiers in Immunology, 2023
Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are indispensable guardians of the immune system and orchestrate the recognition and elimination of cancer cells. Upon encountering a cancer cell, CLs establish a
Elena Ockfen, Elena Ockfen, Liza Filali, Diogo Pereira Fernandes, Diogo Pereira Fernandes, Céline Hoffmann, Clément Thomas   +6 more
doaj   +1 more source