Results 11 to 20 of about 724,662 (381)

Primary immunodeficiency: common variable immunodeficiency [PDF]

Journal of Clinical Medicine of Kazakhstan, 2016
By definition, primary immunodeficiencies are genetically determined diseases, which are fundamental molecular or organic defects associated with impaired immune responses, in this case there is the clinic of infectious and autoimmune diseases, with an increased risk of developing malignancies.
Marina Morenko, Dinara Gabdullina, Oksana Ussenova, Yelena Kovzel   +3 more
openaire   +2 more sources

Research on Rare Diseases in Germany – The GAIN Registry: a registry for individuals with congenital multi-organ autoimmune diseases [PDF]

Journal of Health Monitoring, 2023
Background: Patient registries are an important tool for networking medical caregivers and research, especially in the field of rare diseases. Individuals afflicted by multi-organ autoimmune diseases typically suffer from inflammation of multiple organs.
Cynthia Stapornwongkul, Alexandra Nieters, Paulina Staus, Stephan Rusch, Anita Delor, Ulrich Baumann, Julius Wehrle, Melanie Boerries, Markus G. Seidel, Bodo Grimbacher, Gerhard Kindle   +10 more
doaj   +1 more source

Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study

Frontiers in Immunology, 2021
Predominantly antibody deficiencies (PAD) are a heterogeneous group of disorders characterized by dysfunctional antibody production, low immunoglobulin levels in serum and impaired vaccine responses.
Jessica Rojas-Restrepo, Jessica Rojas-Restrepo, Jessica Rojas-Restrepo, Andrés Caballero-Oteyza, Andrés Caballero-Oteyza, Andrés Caballero-Oteyza, Katrin Huebscher, Katrin Huebscher, Hanna Haberstroh, Hanna Haberstroh, Manfred Fliegauf, Manfred Fliegauf, Manfred Fliegauf, Baerbel Keller, Baerbel Keller, Baerbel Keller, Robin Kobbe, Klaus Warnatz, Klaus Warnatz, Klaus Warnatz, Stephan Ehl, Stephan Ehl, Michele Proietti, Michele Proietti, Michele Proietti, Michele Proietti, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +31 more
doaj   +1 more source

From Flies to Men: ROS and the NADPH Oxidase in Phagocytes

Frontiers in Cell and Developmental Biology, 2021
The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient antimicrobial defense system against microorganisms. The NADPH oxidases (NOX), which are predominantly localized to endosomes, and the electron transport chain in ...
Zohreh Mansoori Moghadam, Zohreh Mansoori Moghadam, Philipp Henneke, Philipp Henneke, Julia Kolter   +4 more
doaj   +1 more source

Monocyte progenitors give rise to multinucleated giant cells

Nature Communications, 2021
Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.
Anne Kathrin Lösslein, Florens Lohrmann, Lisa Scheuermann, Kourosh Gharun, Jana Neuber, Julia Kolter, Aaron James Forde, Christian Kleimeyer, Ying Yee Poh, Matthias Mack, Antigoni Triantafyllopoulou, Micah D. Dunlap, Shabaana A. Khader, Maximilian Seidl, Alexandra Hölscher, Christoph Hölscher, Xue Li Guan, Anca Dorhoi, Philipp Henneke   +18 more
doaj   +1 more source

Impact of IL-15 and latency reversing agent combinations in the reactivation and NK cell-mediated suppression of the HIV reservoir

Scientific Reports, 2022
Inhibitors of histone deacetylases (HDACis) are major latency reversing agent (LRA) candidates in ‘shock and kill’ strategies to eradicate the HIV reservoir in infected patients.
Daniela Angela Covino, Maria Giovanna Desimio, Margherita Doria   +2 more
doaj   +1 more source

Intra-Household and Close-Contact SARS-CoV-2 Transmission Among Children – a Systematic Review

Frontiers in Pediatrics, 2021
Introduction: The outbreak of the novel coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a range of emergency measures worldwide. Early in the pandemic, children were suspected to act as
Benedikt D. Spielberger, Tessa Goerne, Tessa Goerne, Anne Geweniger, Philipp Henneke, Philipp Henneke, Roland Elling, Roland Elling   +7 more
doaj   +1 more source

Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)

EMBO Molecular Medicine, 2022
Primary hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by impaired lymphocyte cytotoxicity. First‐line therapeutic regimens directed against activated immune cells or secreted cytokines show limited efficacy since they do
Kristoffer Weißert, Sandra Ammann, Tamara Kögl, Viviane Dettmer‐Monaco, Christoph Schell, Toni Cathomen, Stephan Ehl, Peter Aichele   +7 more
doaj   +1 more source

Resident macrophages acquire innate immune memory in staphylococcal skin infection

eLife, 2020
Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections.
Reinhild Feuerstein, Aaron James Forde, Florens Lohrmann, Julia Kolter, Neftali Jose Ramirez, Jakob Zimmermann, Mercedes Gomez de Agüero, Philipp Henneke   +7 more
doaj   +1 more source

A Quantitative Analysis of Dynamic Mechanisms Regulating HIV Latency and Activation [PDF]

Prog. Biochem. Biophys. 2023,50(2):385-396, 2022
Objective: The reservoir of human immunodeficiency virus (HIV) latently infected cells is the major obstacle for eradication of acquired immunodeficiency syndrome (AIDS). Due to the noisy environment and multiple influencing factors in the organism, current dynamical models cannot reach a common understanding of the molecular mechanism of HIV latency ...
arxiv   +1 more source