Results 1 to 10 of about 14,164 (149)

A rare case of systemic AL-amyloidosis under the mask of myocardial infarction in the absence of myocardial hypertrophy: case report [PDF]

КардиоСоматика, 2022
Systemic amyloidosis is a group of diseases associated with extracellular deposition of fibrillar proteins, resulting in the loss of normal organ structure and function. AL-amyloidosis occurs when amyloid is deposited, consisting of full-length lambda or
Svetlana A. Boldueva, Dmitriy S. Evdokimov, Marina V. Rozhdestvenskaya, Sergey A. Vinnichuk, Lyubov B. Mitrofanova   +4 more
doaj   +1 more source

Histiocytic Glomerulopathy With Noncrystalline Inclusion Associated With IgG-Kappa Plasma Cell Dyscrasia

Kidney Medicine, 2023
The kidney pathology of monoclonal gammopathy of renal significance varies greatly. In this report, we present a woman in her 20s with nephrotic syndrome and monoclonal immunoglobulin G kappa (serum and urine) without diabetes.
Ai Katsuma, Masahiro Okabe, Hiroyuki Ueda, Takashi Ehara, Yutaka Yamaguchi, Yoichi Miyazaki, Takashi Yokoo   +6 more
doaj   +1 more source

Gut mycobiome dysbiosis contributes to the development of hypertension and its response to immunoglobulin light chains

Frontiers in Immunology, 2022
ObjectivesHuman gut microbiome has gained great attention for its proposed roles in the development of hypertension. The fungal microbiome in the human gut (i.e.
Yeqing Zou, Anxing Ge, Brako Lydia, Chen Huang, Qianying Wang, Yanbo Yu   +5 more
doaj   +1 more source

Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]

PLoS ONE, 2014
Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita, Akiko Sano, Hua Wu, Jin-An Jiao, Poothappillai Kasinathan, Eddie J Sullivan, Zhongde Wang, Yoshimi Kuroiwa   +7 more
doaj   +1 more source

Immunoglobulin kappa chain allotypes (KM) in onchocerciasis. [PDF]

Journal of Clinical Investigation, 1995
GM and KM allotypes, powerful tools for genetic characterization of human populations, have been shown to play an important role in genetic predisposition to some infectious diseases. Two diverse racial groups--Afro-Ecuadorians and Amerindians--living in a single restricted geographical area of Ecuador, appear to have different risk factors for ...
J P, Pandey, L H, Elson, S E, Sutherland, R H, Guderian, E, Araujo, T B, Nutman   +5 more
openaire   +2 more sources

Pattern of serum immunoglobulins and free light chain levels among patients diagnosed with multiple myeloma in Southeast Nigeria

International Journal of Medicine and Health Development, 2023
Background: Abnormal plasma cells in multiple myeloma produce excessive amounts of immunoglobulins and free light chains, of which certain patterns predict patient survival.
Ifeyinwa D Nnakenyi, Anazoeze J Madu, Ifeoma C Ajuba, Sunday Ocheni, Gladys U Ilechukwu, Nnenna Ogbodo, Oji A Nnachi   +6 more
doaj   +1 more source

Evolution of immunoglobulin kappa chain variable region genes in vertebrates [PDF]

Molecular Biology and Evolution, 1998
The major source of immunoglobulin diversity is variation in DNA sequence among multiple copies of variable region (V) genes of the heavy- and light-chain multigene families. In order to clarify the evolutionary pattern of the multigene family of immunoglobulin light kappa chain V region (V kappa) genes, phylogenetic analyses of V kappa genes from ...
T, Sitnikova, M, Nei
openaire   +2 more sources

Human Gm, Km, and Am Allotypes: WHO/IMGT Nomenclature and IMGT Unique Numbering for Immunoinformatics and Therapeutical Antibodies

BioMedInformatics, 2023
Human immunoglobulin allotypes are allelic antigenic determinants (or “markers”) determined serologically, classically by hemagglutination inhibition, on the human immunoglobulin (IG) or antibody heavy and light chains. The allotypes have been identified
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus. [PDF]

Journal of Clinical Investigation, 1998
To determine whether receptor editing of Vkappa genes was involved in the pathogenesis of systemic lupus erythematosus (SLE), the usage of Vkappa and Jkappa gene elements from individual peripheral CD19(+) B cells obtained from a patient with untreated SLE was examined.
T, Dörner, S J, Foster, N L, Farner, P E, Lipsky   +3 more
openaire   +2 more sources

For Breast Cancer Prognosis, Immunoglobulin Kappa Chain Surfaces to the Top [PDF]

Clinical Cancer Research, 2012
Abstract The stromal immunoglobulin kappa chain (IGKC) has been validated as an immunologic biomarker of prognosis and response to therapy in human breast cancer and other cancers. This validation emphasizes the key role of humoral immunity in control of cancer progression and has major implications for determining prognosis of ...
Theresa L, Whiteside, Soldano, Ferrone
openaire   +2 more sources