Results 11 to 20 of about 14,210 (195)
High Inter-Individual Diversity of Point Mutations, Insertions, and Deletions in Human Influenza Virus Nucleoprotein-Specific Memory B Cells. [PDF]
PLoS ONE, 2015 The diversity of virus-specific antibodies and of B cells among different individuals is unknown. Using single-cell cloning of antibody genes, we generated recombinant human monoclonal antibodies from influenza nucleoprotein-specific memory B cells in ...
Sven Reiche +5 more
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Diagnosing a Challenging Case of Primary Amyloidosis using Capillary Electrophoresis [PDF]
National Journal of Laboratory Medicine, 2021 Amyloid Light chain (AL) amyloidosis is characterised by deposition of intact free light chains or their fragments in extracellular space. Here, authors describe the journey of a diagnostically challenging patient who presented with features of ...
rashmi verma +4 more
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Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis. [PDF]
PLoS ONE, 2009 The amyloidoses are protein misfolding diseases characterized by the deposition of amyloid that leads to cell death and tissue degeneration. In immunoglobulin light chain amyloidosis (AL), each patient has a unique monoclonal immunoglobulin light chain ...
Tanya L Poshusta +5 more
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mAbs, 2021 Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching +7 more
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Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species
Frontiers in Immunology, 2022 Studies in humans and mice indicate the critical role of the surrogate light chain in the selection of the productive immunoglobulin repertoire during B cell development.
Marek Sinkora +5 more
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Practical Laboratory Medicine, 2021 Heavy chain isotypes of low level monoclonal immunoglobulins are sometimes obscured in serum immunofixation electrophoresis (SIFE) by a heavy background of polyclonal immunoglobulins.
Asad Ullah +4 more
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Biomedicines, 2022 The gold standard for detecting intrathecal immunoglobulin synthesis is the determination of the oligoclonal band (OCB) in the cerebrospinal fluid (CSF) using isoelectric focusing (IEF).
Bastian Weiss +8 more
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Frontiers in Immunology, 2016 Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the
Catherine L Townsend +7 more
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Sequences related to immunoglobulin kappa chain messenger RNA in T cells. [PDF]
Proceedings of the National Academy of Sciences, 1976 We investigated by molecular hybridization whether T cells contain RNA sequences homologous to RNA which codes for immunoglobulin kappa-chain (k-chain). A radioactive probe of complementary DNA (cDNA) was prepared by transcription of purified k-chain mRNA from mouse myeloma MOPC-41 with reverse transcriptase (RNA-dependent-DNA nucleotidyltransferase ...
U, Storb +5 more
openaire +2 more sources
Kidney Research and Clinical Practice, 2014 Fanconi syndrome (FS) is a rare condition that is characterized by defects in the proximal tubular function. A 48-year-old woman was admitted for evaluation of proteinuria.
Do Hee Kim +12 more
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