Results 21 to 30 of about 14,210 (195)

Simultaneous tubular and glomerular involvement with cryoglobulinemia vasculitis in multiple myeloma

open access: yesSaudi Journal of Kidney Diseases and Transplantation, 2019
Renal manifestations in myeloma are varied. Tubulopathic light chains cause cast nephropathy or proximal tubulopathy, usually associated with tubulointerstitial nephritis.
Zafirah Zahir   +3 more
doaj   +1 more source

First third-generation CAR T cell application targeting CD19 for the treatment of systemic IgM AL amyloidosis with underlying marginal zone lymphoma

open access: yesBiomarker Research, 2023
Light chain amyloidosis (AL) is a rare disease caused by the generalized deposition of misfolded free light chains. Patients with immunoglobulin M gammopathy (IgM) and indolent B-cell lymphoma such as marginal zone lymphoma (MZL) may in some instances ...
Felix Korell   +8 more
doaj   +1 more source

Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene. [PDF]

open access: yesMolecular and Cellular Biology, 1984
Each of two severely defective mouse kappa-chain genes has acquired a different intracisternal A particle (IAP) element within one of its introns. One IAP element generated 6-base-pair direct repeats upon insertion. In contrast, the other IAP element was not flanked by direct repeats and was missing a single nucleotide from its 3' terminus.
R G, Hawley, M J, Shulman, N, Hozumi
openaire   +2 more sources

DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF INTRATHECAL SYNTHESIS OF IMMUNOGLOBULIN FREE LIGHT CHAINS IN MULTIPLE SCLEROSIS

open access: yesМедицинская иммунология, 2015
Increased intrathecal synthesis and oligoclonal banding of immunoglobulins (Ig) in cerebrospinal fluid (CSF) are major immunological findings in multiple sclerosis.
V. D. Nazarov   +5 more
doaj   +1 more source

Light chain nephropathy

open access: yesSaudi Journal of Kidney Diseases and Transplantation, 2015
Light chain deposition disease (LCDD) is characterized by the tissue deposition of monotypic immunoglobulin light chains of either kappa or lambda isotype.
Sihem Darouich   +6 more
doaj   +1 more source

Targeting Inflammation in the Diagnosis, Management, and Prevention of Cardiovascular Diseases

open access: yesGlobal Heart, 2022
Inflammation plays an important role in the development and progression of cardiovascular diseases (CVDs). Hypertension and hyperlipidemia are the key risk factors of CVDs and induce inflammation in the heart and vessels.
Akira Matsumori
doaj   +1 more source

Multiple-alphabet amino acid sequence comparisons of the immunoglobulin kappa-chain constant domain. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1985
We compare the amino acid sequences of the constant domains of the immunoglobulin kappa chain of human, mouse, and rabbit by using four classification schemes ("alphabets") of the 20 amino acids based on their chemical, functional, charge, and structural properties. The comparison reveals three regions of pronounced similarity across the three species,
S, Karlin, G, Ghandour
openaire   +2 more sources

The active immunoglobulin kappa chain gene is packaged by non-ubiquitin-conjugated nucleosomes. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1986
To elucidate the molecular features of active chromatin, we have mapped, by two-dimensional electrophoresis, the protein composition of nucleosomes that package the immunoglobulin kappa chain gene of mouse plasmacytoma cells. Nucleoprotein particles that possess the active kappa chain gene comigrate with bulk mononucleosomes that contain high mobility ...
S Y, Huang   +5 more
openaire   +2 more sources

Laboratory biomarkers for multiple sclerosis and their role in clinical practice

open access: yesNeurologijos seminarai, 2023
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) most commonly diagnosed in young adults. In recent decades, new treatments have emerged that have radically changed the prognosis and quality of life of these patients ...
I. Navickaitë   +2 more
doaj   +3 more sources

Peripheral Neuropathy and VIth Nerve Palsy Related to Randall Disease Successfully Treated by High-Dose Melphalan, Autologous Blood Stem Cell Transplantation, and VIth Nerve Decompression Surgery

open access: yesCase Reports in Medicine, 2010
Randall disease is an unusual cause of extraocular motor nerve (VI) palsy. A 35-year-old woman was hospitalized for sicca syndrome. The physical examination showed general weakness, weight loss, diplopia related to a left VIth nerve palsy, hypertrophy of
C. Foguem   +3 more
doaj   +1 more source

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