Results 31 to 40 of about 14,210 (195)

B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment. [PDF]

Proceedings of the National Academy of Sciences, 1987
Nuclear extracts from pre-B and B cell lines contain a nuclear DNA binding protein (kappa locus protein, KLP) that specifically recognizes a DNA sequence in the immunoglobulin kappa light chain joining (J) segment gene region. KLP is not observed in mature B cells, T cells, or nonlymphoid cell types.
Weaver, David, Baltimore, David
openaire   +3 more sources

Assessment of Serum Free Light Chains as a Marker of Diabetic Nephropathy; A Cross-Sectional Study in the Kumasi Metropolis

Frontiers in Clinical Diabetes and Healthcare, 2022
AimsAlthough traditional tests such as serum urea, creatinine, and microalbuminuria have been widely employed in the diagnosis of diabetic nephropathy, their sensitivity and accuracy are limited because kidney damage precedes the excretion of these ...
Elizabeth Sorvor, Elizabeth Sorvor, William K. B. A. Owiredu, Perditer Okyere, Perditer Okyere, Max Efui Annani-Akollor, Sampson Donkor, Richard Bannor, Richard Bannor, Felix B.K. Sorvor, Richard K.D. Ephraim   +10 more
doaj   +1 more source

The disulphide bridges of immunoglobulin ϰ-chains [PDF]

Biochemical Journal, 1966
The arrangement of the disulphide bridges of the major component of the light chains of immunoglobulins (kappa-chains) has been studied in the Bence-Jones proteins. Three disulphide bridges have been found. An interchain bridge at the C-terminus has been shown to occur in the dimers of all the proteins studied and was characterized by symmetrical ...
openaire   +2 more sources

Concordance rate between oligoclonal bands and the Kappa index in patients with suspected multiple sclerosis (MS)

Arquivos de Neuro-Psiquiatria
Background Oligoclonal bands (OCBs) and Kappa free light chains (FLCs) in the cerebrospinal fluid (CSF) are sensitive markers of intrathecal immunoglobulin (Ig)G synthesis in patients with multiple sclerosis.
Renan Barros Domingues, Márcio Vega dos Santos, Daiane Salomão, Carlos Senne   +3 more
doaj   +1 more source

Kappa Index versus CSF Oligoclonal Bands in Predicting Multiple Sclerosis and Infectious/Inflammatory CNS Disorders

Diagnostics, 2020
Background: Cerebrospinal fluid (CSF) kappa free light chains (KFLC) are gaining increasing interest as markers of intrathecal immunoglobulin synthesis. The main aim of this study was to assess the diagnostic accuracy (AUC) of the kappa index (CSF/serum ...
Diana Ferraro, Roberta Bedin, Patrizia Natali, Diego Franciotta, Krzysztof Smolik, Mario Santangelo, Paolo Immovilli, Valentina Camera, Francesca Vitetta, Matteo Gastaldi, Tommaso Trenti, Stefano Meletti, Patrizia Sola   +12 more
doaj   +1 more source

Renal Expression of Light Chain Binding Proteins

Frontiers in Medicine, 2021
Overproduction of human light chains (LCs) and immunoglobulins can result in various forms of renal disease such as cast nephropathy, monoclonal immunoglobulin deposition disease, LC proximal tubulopathy, AL amyloidosis, and crystal storing histiocytosis.
Thomas Reiter, Sahra Pajenda, David O'Connell, David O'Connell, Ciara Lynch, Ciara Lynch, Sebastian Kapps, Hermine Agis, Alice Schmidt, Ludwig Wagner, Nelson Leung, Wolfgang Winnicki   +11 more
doaj   +1 more source

Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors [PDF]

OncoImmunology, 2012
Infiltration of plasma cells is associated with better prognosis in breast, lung and colon cancer. Immunoglobulin κ chain (IGKC) is now available as a single, robust immune marker predicting metastasis-free survival and response to chemotherapy. This will facilitate a deeper understanding of the role of the humoral immune system in cancer development.
Schmidt, Marcus, Micke, Patrick, Gehrmann, Mathias, Hengstler, Jan G.   +3 more
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Idiotype-specific intravenous immunoglobulin for therapy of immunoglobulin kappa free light chain deficiency

Human Vaccines & Immunotherapeutics, 2019
Deficient antibody production in patients with common variable immunodeficiency (CVID) is accompanied by an inability to produce free light chains (FLCs), particularly kappa (κ) FLC, due to B-cell dysfunction.
Adina Elena Stanciu, Monica Popescu, Dan Cristian Gheorghe   +2 more
doaj   +1 more source

Subgroup Analysis in Multiple Myeloma Patients under Sixty Years: A Single-Center Study

İstanbul Medical Journal, 2021
Introduction:Multiple myeloma (MM) constitutes approximately 10% of hematological malignan-cies with abnormal proliferation of plasma cells, which causes an abnormal increase of monoclonal immunoglobulin light chains.
İstemi Serin, Mehmet Hilmi Doğu
doaj   +1 more source

DNA sequence of the constant gene region of the mouse immunoglobulin kappa chain

Nucleic Acids Research, 1981
The constant (C; ref. 3) gene segment of the immunoglobulin kappa light chain and about 1 kb upstream as well as downstream of the segment have been sequenced. The sequences of the C gene segment itself and parts of the upstream region were determined both in liver and in myeloma T DNA clones derived from the same mouse inbred strain.
W, Altenburger, P S, Neumaier, M, Steinmetz, H G, Zachau   +3 more
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