Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse: good, bad, or both? [PDF]
Frontiers in Immunology, 2023 Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are indispensable guardians of the immune system and orchestrate the recognition and elimination of cancer cells. Upon encountering a cancer cell, CLs establish a
Elena Ockfen +6 more
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Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems [PDF]
BMC Biology, 2011 Background Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target
Arico Maurizo +5 more
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RBL-2H3 Mast Cell Receptor Dynamics in the Immunological Synapse [PDF]
Biophysica, 2022 The RBL-2H3 mast cell immunological synapse dynamics is often simulated with reaction–diffusion and Fokker–Planck equations. The equations focus on how the cell synapse captures receptors following an immune response, where the receptor capture at the ...
Ming Chih Tsai, Kathrin Spendier
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LFA-1 Activation in T-Cell Migration and Immunological Synapse Formation [PDF]
Cells, 2023 Integrin LFA-1 plays a critical role in T-cell migration and in the formation of immunological synapses. LFA-1 functions through interacting with its ligands with differing affinities: low, intermediate, and high.
Huiping Shi, Bojing Shao
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Explainable machine learning for profiling the immunological synapse and functional characterization of therapeutic antibodies [PDF]
Nature Communications, 2023 Therapeutic antibodies are widely used to treat severe diseases. Most of them alter immune cells and act within the immunological synapse; an essential cell-to-cell interaction to direct the humoral immune response.
Sayedali Shetab Boushehri +8 more
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Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse [PDF]
Frontiers in Immunology, 2021 The essential microelement zinc plays immunoregulatory roles via its ability to influence signaling pathways. Zinc deficiency impairs overall immune function and resultantly increases susceptibility to infection.
Bonah Kim +7 more
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CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse [PDF]
Frontiers in Immunology, 2022 T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert their functions requiring high sensibility and specificity, T cells need to integrate different stimuli from the surrounding ...
Barbara Molon +5 more
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A Ciliary View of the Immunological Synapse [PDF]
Cells, 2019 The primary cilium has gone from being a vestigial organelle to a crucial signaling hub of growing interest given the association between a group of human disorders, collectively known as ciliopathies, and defects in its structure or function.
Chiara Cassioli, Cosima T. Baldari
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T lymphocyte myosin IIA is required for maturation of the immunological synapse [PDF]
Frontiers in Immunology, 2012 The role of non-muscle myosin IIA (heavy chain encoded by the non-muscle myosin heavy chain 9 gene, Myh9) in immunological synapse formation is controversial.
Sudha eKumari +6 more
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T cell stiffness is enhanced upon formation of immunological synapse [PDF]
eLife, 2021 T cells are activated by target cells via an intimate contact, termed immunological synapse (IS). Cellular mechanical properties, especially stiffness, are essential to regulate cell functions.
Philipp Jung +4 more
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