LFA-1 Activation in T-Cell Migration and Immunological Synapse Formation [PDF]
Cells, 2023 Integrin LFA-1 plays a critical role in T-cell migration and in the formation of immunological synapses. LFA-1 functions through interacting with its ligands with differing affinities: low, intermediate, and high.
Huiping Shi, Bojing Shao
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Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse: good, bad, or both? [PDF]
Frontiers in Immunology, 2023 Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are indispensable guardians of the immune system and orchestrate the recognition and elimination of cancer cells. Upon encountering a cancer cell, CLs establish a
Elena Ockfen +6 more
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Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse [PDF]
Frontiers in Immunology, 2021 The essential microelement zinc plays immunoregulatory roles via its ability to influence signaling pathways. Zinc deficiency impairs overall immune function and resultantly increases susceptibility to infection.
Bonah Kim +7 more
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CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse [PDF]
Frontiers in Immunology, 2022 T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert their functions requiring high sensibility and specificity, T cells need to integrate different stimuli from the surrounding ...
Barbara Molon +5 more
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T cell stiffness is enhanced upon formation of immunological synapse [PDF]
eLife, 2021 T cells are activated by target cells via an intimate contact, termed immunological synapse (IS). Cellular mechanical properties, especially stiffness, are essential to regulate cell functions.
Philipp Jung +4 more
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A Ciliary View of the Immunological Synapse [PDF]
Cells, 2019 The primary cilium has gone from being a vestigial organelle to a crucial signaling hub of growing interest given the association between a group of human disorders, collectively known as ciliopathies, and defects in its structure or function.
Chiara Cassioli, Cosima T. Baldari
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The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy. [PDF]
Cell Commun Signal, 2020 Chimeric Antigen Receptor (CAR) immunotherapy utilizes genetically-engineered immune cells that express a unique cell surface receptor that combines tumor antigen specificity with immune cell activation.
Liu D +9 more
europepmc +4 more sources
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals. [PDF]
Nat Immunol, 2020 Demetriou P +22 more
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The Actin Cytoskeleton at the Immunological Synapse of Dendritic Cells. [PDF]
Front Cell Dev Biol, 2021 Dendritic cells (DCs) are considered the most potent antigen-presenting cells. DCs control the activation of T cells (TCs) in the lymph nodes. This process involves forming a specialized superstructure at the DC-TC contact zone called the immunological ...
Rodríguez-Fernández JL +1 more
europepmc +2 more sources
In vitro machine learning-based CAR T immunological synapse quality measurements correlate with patient clinical outcomes. [PDF]
PLoS Comput Biol, 2022 The human immune system consists of a highly intelligent network of billions of independent, self-organized cells that interact with each other. Machine learning (ML) is an artificial intelligence (AI) tool that automatically processes huge amounts of ...
Naghizadeh A +9 more
europepmc +2 more sources