Results 1 to 10 of about 19,360 (205)
A Ciliary View of the Immunological Synapse [PDF]
Cells, 2019 The primary cilium has gone from being a vestigial organelle to a crucial signaling hub of growing interest given the association between a group of human disorders, collectively known as ciliopathies, and defects in its structure or function.
Chiara Cassioli, Cosima T. Baldari
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Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse: good, bad, or both? [PDF]
Frontiers in Immunology, 2023 Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are indispensable guardians of the immune system and orchestrate the recognition and elimination of cancer cells. Upon encountering a cancer cell, CLs establish a
Elena Ockfen +6 more
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RBL-2H3 Mast Cell Receptor Dynamics in the Immunological Synapse [PDF]
Biophysica, 2022 The RBL-2H3 mast cell immunological synapse dynamics is often simulated with reaction–diffusion and Fokker–Planck equations. The equations focus on how the cell synapse captures receptors following an immune response, where the receptor capture at the ...
Ming Chih Tsai, Kathrin Spendier
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LFA-1 Activation in T-Cell Migration and Immunological Synapse Formation [PDF]
Cells, 2023 Integrin LFA-1 plays a critical role in T-cell migration and in the formation of immunological synapses. LFA-1 functions through interacting with its ligands with differing affinities: low, intermediate, and high.
Huiping Shi, Bojing Shao
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Explainable machine learning for profiling the immunological synapse and functional characterization of therapeutic antibodies [PDF]
Nature Communications, 2023 Therapeutic antibodies are widely used to treat severe diseases. Most of them alter immune cells and act within the immunological synapse; an essential cell-to-cell interaction to direct the humoral immune response.
Sayedali Shetab Boushehri +8 more
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Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse [PDF]
Frontiers in Immunology, 2021 The essential microelement zinc plays immunoregulatory roles via its ability to influence signaling pathways. Zinc deficiency impairs overall immune function and resultantly increases susceptibility to infection.
Bonah Kim +7 more
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Chemokines and the immunological synapse
Immunology, 2002 The critical event which initiates an adaptive immune response is the interaction of T cells through the T-cell antigen receptor (TCR) with major histocompatibility complex (MHC)–peptide (MHCp) complexes on the surface of antigen-presenting cells (APCs).
Victor L. J. Tybulewicz
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CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse [PDF]
Frontiers in Immunology, 2022 T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert their functions requiring high sensibility and specificity, T cells need to integrate different stimuli from the surrounding ...
Barbara Molon +5 more
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Lipid switches in the immunological synapse. [PDF]
J Biol ChemAdaptive immune responses comprise the activation of T cells by peptide antigens that are presented by proteins of the Major Histocompatibility Complex (MHC) on the surface of an antigen-presenting cell. As a consequence of the T cell receptor interacting productively with a certain peptide-MHC complex, a specialized cell-cell junction known as the ...
Griffiths G, Brügger B, Freund C.
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The dendritic cell side of the immunological synapse [PDF]
Biomolecular Concepts, 2016 Immune responses are initiated by the interactions between antigen-presenting cells (APCs), such as dendritic cells (DCs), with responder cells, such as T cells, via a tight cellular contact interface called the immunological synapse.
Verboogen Danielle R.J. +5 more
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